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Evaluating the Impact of Different Hypercaloric Diets on Weight Gain, Insulin Resistance, Glucose Intolerance, and its Comorbidities in Rats

2019-05-28Journal article Open access
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datacite.subject.fosCiências Médicas::Medicina Básica
datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorMelo, Bernardete F.
dc.contributor.authorSacramento, Joana F.
dc.contributor.authorRibeiro, Maria J.
dc.contributor.authorPrego, Claudia S.
dc.contributor.authorCorreia, Miguel C.
dc.contributor.authorCoelho, Joana C.
dc.contributor.authorCunha-Guimaraes, Joao P.
dc.contributor.authorRodrigues, Tiago
dc.contributor.authorMartins, Ines B.
dc.contributor.authorSeiça, Raquel M.
dc.contributor.authorMatafome, Paulo
dc.contributor.authorConde, Silvia V.
dc.contributor.authorGuarino, Maria Pedro
dc.date.accessioned2025-11-18T15:04:49Z
dc.date.available2025-11-18T15:04:49Z
dc.date.issued2019-05-28
dc.description.abstractAnimal experimentation has a long history in the study of metabolic syndrome-related disorders. However, no consensus exists on the best models to study these syndromes. Knowing that different diets can precipitate different metabolic disease phenotypes, herein we characterized several hypercaloric rat models of obesity and type 2 diabetes, comparing each with a genetic model, with the aim of identifying the most appropriate model of metabolic disease. The effect of hypercaloric diets (high fat (HF), high sucrose (HSu), high fat plus high sucrose (HFHSu) and high fat plus streptozotocin (HF+STZ) during different exposure times (HF 3 weeks, HF 19 weeks, HSu 4 weeks, HSu 16 weeks, HFHSu 25 weeks, HF3 weeks + STZ) were compared with the Zucker fatty rat. Each model was evaluated for weight gain, fat mass, fasting plasma glucose, insulin and C-peptide, insulin sensitivity, glucose tolerance, lipid profile and liver lipid deposition, blood pressure, and autonomic nervous system function. All animal models presented with insulin resistance and dyslipidemia except the HF+STZ and HSu 4 weeks, which argues against the use of these models as metabolic syndrome models. Of the remaining animal models, a higher weight gain was exhibited by the Zucker fatty rat and wild type rats submitted to a HF diet for 19 weeks. We conclude that the latter model presents a phenotype most consistent with that observed in humans with metabolic disease, exhibiting the majority of the phenotypic features and comorbidities associated with type 2 diabetes in humans.eng
dc.description.sponsorshipThis study was supported by the Portuguese Foundation for Science and Technology (FCT), grants EXPL/NEU-SCC/2183/2013 and Pest-SAU/UI3282/2011 and by Galvani Bioelectronics. J.F.S. and B.M. were supported by PhD Grants from Portuguese Foundation for Science and Technology Reference PD/BD/105890/2014 and PD/BD/128336/2017, respectively
dc.identifier.citationMelo, B. F., Sacramento, J. F., Ribeiro, M. J., Prego, C. S., Correia, M. C., Coelho, J. C., ... & Conde, S. V. (2019). Evaluating the impact of different hypercaloric diets on weight gain, insulin resistance, glucose intolerance, and its comorbidities in rats. Nutrients, 11(6), 1197. https://doi.org/10.3390/nu11061197
dc.identifier.doi10.3390/nu11061197
dc.identifier.issn2072-6643
dc.identifier.urihttp://hdl.handle.net/10400.8/14655
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationModulation of carotid body activity as a therapeutic intervention in metabolic diseases.
dc.relation.hasversionhttps://www.mdpi.com/2072-6643/11/6/1197
dc.relation.ispartofNutrients
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAdipose tissue
dc.subjectAnimal models
dc.subjectGlucose tolerance
dc.subjectHypertension
dc.subjectInsulin sensitivity
dc.subjectMetabolic syndrome
dc.subjectObesity
dc.subjectType 2 diabetes
dc.subjectWeight gain
dc.subjectFood Science
dc.subjectNutrition and Dietetics
dc.subjectSDG 3 - Good Health and Well-being
dc.titleEvaluating the Impact of Different Hypercaloric Diets on Weight Gain, Insulin Resistance, Glucose Intolerance, and its Comorbidities in Ratseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleModulation of carotid body activity as a therapeutic intervention in metabolic diseases.
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//PD%2FBD%2F105890%2F2014/PT
oaire.citation.endPage19
oaire.citation.issue6
oaire.citation.startPage1
oaire.citation.titleNutrients
oaire.citation.volume11
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameGuarino
person.givenNameMaria Pedro
person.identifier.ciencia-idF21A-BD01-2D52
person.identifier.orcid0000-0001-6079-1105
person.identifier.ridB-5594-2015
person.identifier.scopus-author-id56348477000
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isAuthorOfPublicationf163d4df-1e45-4278-affa-5994f206becf
relation.isAuthorOfPublication.latestForDiscoveryf163d4df-1e45-4278-affa-5994f206becf
relation.isProjectOfPublication8d184299-84d1-4918-9ab6-1ae18bb57139
relation.isProjectOfPublication.latestForDiscovery8d184299-84d1-4918-9ab6-1ae18bb57139

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