Publication
Persistence of measles antibodies, following changes in the recommended age for the second dose of MMR-vaccine in Portugal
datacite.subject.fos | Ciências Médicas::Ciências da Saúde | |
datacite.subject.sdg | 03:Saúde de Qualidade | |
dc.contributor.author | Gonçalves, Guilherme | |
dc.contributor.author | Frade, João | |
dc.contributor.author | Nunes, Carla | |
dc.contributor.author | Mesquita, João Rodrigo | |
dc.contributor.author | Nascimento, Maria São José | |
dc.date.accessioned | 2025-06-04T14:58:08Z | |
dc.date.available | 2025-06-04T14:58:08Z | |
dc.date.issued | 2015-09 | |
dc.description.abstract | In populations vaccinated with two doses of combined measles–mumps–rubella vaccine (MMR), the serum levels of antibodies against measles depend on the vaccination schedule, time elapsed from the last dose and the area-specific epidemiological situation. Variables measuring “schedule” are age at first and second doses of MMR and intervals derived from that. Changes in vaccination schedules have been made in Portugal. The specific objectives of this study were to measure the association between those potential determinants and the concentration of measles-specific IgG antibodies, after the second dose of MMR. Convenience samples of three Portuguese birth cohorts were selected for this study (41, 66 and 60 born, respectively, in 2001–2003, 1990–1993 and 1994–1995). Geometric mean concentrations (GMC) for measles IgG were, respectively, 934, 251 and 144 mIU/ml; p < 0.001). Anti-measles-IgG serum concentration decreased with time since last vaccination (waning immunity) and was not influenced by any other component of vaccination schedule, namely age at vaccination with the second dose of MMR. Waning levels of measles antibodies have been observed elsewhere but not as fast as it was observed in Portuguese birth cohorts in this study. Changes in the vaccination schedules might have to be considered in the future. | eng |
dc.description.sponsorship | Acknowledgements Commercial ELISA kits were purchased by the Population Studies Department of the Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Portugal and Escola Superior de Saúde, Instituto Politécnico de Leiria (ESS-IPL), Leiria, Portugal. The authors are grateful for the support given by the National School of Public Health, Lisbon. The authors acknowledge Dr. Leonie Prasad for reviewing the manuscript. We thank Dr. Ana Manso and Dr. António Serra to authorise the study in the health centre of Sabugal, Dr Jorge Costa to authorise consulting vaccination records in Leiria, Prof José Carlos Gomes, Diretcor of ESS-IPL for all his support in several activities and for authorising this study in his school, Professor Artur Águas and Dr. Beatriz Godinho to authorise keeping the sera in the freezers of their laboratories until transport to the laboratory where antibody measurements were made, nurses Susana Frade, Ana Gomes, Fátima Soares, Dina Pascoal and Júlia Oliveira, for their cooperation collecting blood samples and consulting vaccination histories. The participants and their parents (cohorts born 1990–1995) are also gratefully acknowledged. | |
dc.identifier.citation | Gonçalves, Guilherme & Graça Frade, João Manuel & Nascimento, Maria & Mesquita, João & Nunes, Carla. (2016). Persistence of rubella and mumps antibodies, following changes in the recommended age for the second dose of MMR vaccine in Portugal. Epidemiology and infection. -1. 1-9. 10.1017/S0950268816001655. | |
dc.identifier.doi | 10.1016/j.vaccine.2015.08.057 | |
dc.identifier.issn | 0264-410X | |
dc.identifier.uri | http://hdl.handle.net/10400.8/13109 | |
dc.language.iso | eng | |
dc.peerreviewed | yes | |
dc.publisher | Elsevier | |
dc.relation.hasversion | https://www.sciencedirect.com/science/article/pii/S0264410X15011858 | |
dc.relation.ispartof | Vaccine | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | |
dc.subject | Measles–mumps–rubella (MMR) vaccine | |
dc.subject | Immunisation | |
dc.subject | Antibodies | |
dc.subject | Measles | |
dc.subject | Vaccination schedule | |
dc.title | Persistence of measles antibodies, following changes in the recommended age for the second dose of MMR-vaccine in Portugal | eng |
dc.type | journal article | |
dspace.entity.type | Publication | |
oaire.citation.endPage | 5063 | |
oaire.citation.issue | 39 | |
oaire.citation.startPage | 5057 | |
oaire.citation.title | Vaccine | |
oaire.citation.volume | 33 | |
oaire.version | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |
person.familyName | Frade | |
person.givenName | João | |
person.identifier.ciencia-id | C91E-69C4-8734 | |
person.identifier.orcid | 0000-0002-4947-1052 | |
relation.isAuthorOfPublication | b73045c9-3871-4883-9dc5-e5693d2861b3 | |
relation.isAuthorOfPublication.latestForDiscovery | b73045c9-3871-4883-9dc5-e5693d2861b3 |
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