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Using time-lapse omics correlations to integrate toxicological pathways of a formulated fungicide in a soil invertebrate

2019-02Journal article Restricted access
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dc.contributor.authorSimões, Tiago
dc.contributor.authorNovais, Sara C.
dc.contributor.authorNatal-da-Luz, Tiago
dc.contributor.authorDevreese, Bart
dc.contributor.authorde Boer, Tjalf
dc.contributor.authorRoelofs, Dick
dc.contributor.authorSousa, José P.
dc.contributor.authorVan Straalen, Nico M.
dc.contributor.authorLemos, Marco F. L.
dc.date.accessioned2019-10-11T14:38:55Z
dc.date.available2019-10-11T14:38:55Z
dc.date.issued2019-02
dc.date.updated2019-10-07T10:45:52Z
dc.descriptionThis work was supported by FCT through the projects UID/MAR/ 04292/2013, ENVIRONOME (PTDC/AGR-PRO/3496/2012 - POCI-01-0145-FEDER-016773), and grants awarded to TS (SFRH/BD/98266/ 2013), SN (SFRH/BPD/94500/2013), and TNL (SFRH/BPD/110943/ 2015). Project was also partially funded by the Integrated Programme of SR&TD “SmartBioR” (reference Centro-01-0145-FEDER000018) cofunded by Centro 2020 program, Portugal2020, European Union, through the European Regional Development Fund. DR was also supported by EU FP7 Sustainable Nanotechnologies project (SUN, grant number 604305).
dc.description.abstractThe use of an integrative molecular approach can actively improve the evaluation of environmental health status and impact of chemicals, providing the knowledge to develop sentinel tools that can be integrated in risk assessment studies, since gene and protein expressions represent the first response barriers to anthropogenic stress. This work aimed to determine the mechanisms of toxic action of a widely applied fungicide formulation (chlorothalonil), following a time series approach and using a soil model arthropod, Folsomia candida. To link effects at different levels of biological organization, data were collected on reproduction, gene expression and protein levels, in a time series during exposure to a natural soil. Results showed a mechanistic mode of action for chlorothalonil, affecting pathways of detoxification and excretion, immune response, cellular respiration, protein metabolism and oxidative stress defense, causing irregular cell signaling (JNK and NOD ½ pathways), DNA damage and abnormal cell proliferation, leading to impairment in developmental features such as molting cycle and reproduction. The omics datasets presented highly significant positive correlations between the gene expression levels at a certain time-point and the corresponding protein products 2e3 days later. The integrated omics in this study has provided useful insights into pesticide mechanisms of toxicity, evidencing the relevance of such analyses in toxicological studies, and highlighting the importance of considering a time-series when integrating these datasets.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSimões, T., Novais, S. C., Lemos, M. F. L., Natal-da-Luz, T., Sousa, J. P., de Boer, T., … Devreese, B. (2019). Using time-lapse omics correlations to integrate toxicological pathways of a formulated fungicide in a soil invertebrate. Environmental Pollution, 246, 845–854. https://doi.org/10.1016/j.envpol.2018.12.069pt_PT
dc.identifier.doi10.1016/j.envpol.2018.12.069
dc.identifier.issn0269-7491
dc.identifier.slugcv-prod-143017
dc.identifier.urihttp://hdl.handle.net/10400.8/4190
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationMARE - Marine and Environmental Sciences Centre
dc.relationLINKEDIN - LINKING EFFECTS AT DIFFERENT LEVELS OF BIOLOGICAL ORGANIZATION: INSIGHTS INTO MECHANISMS OF PESTICIDE TOXICITY
dc.relationInfluence of soil management on soil biodiversity and ecosystem services provisioning under climate change scenarios
dc.relation.ispartofEnvironmental Pollutionen_US
dc.subjectCollembolanpt_PT
dc.subjectEnvironmentpt_PT
dc.subjectFungicidespt_PT
dc.subjectOmicspt_PT
dc.subjectSoilpt_PT
dc.titleUsing time-lapse omics correlations to integrate toxicological pathways of a formulated fungicide in a soil invertebratept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMARE - Marine and Environmental Sciences Centre
oaire.awardTitleLINKEDIN - LINKING EFFECTS AT DIFFERENT LEVELS OF BIOLOGICAL ORGANIZATION: INSIGHTS INTO MECHANISMS OF PESTICIDE TOXICITY
oaire.awardTitleInfluence of soil management on soil biodiversity and ecosystem services provisioning under climate change scenarios
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMAR%2F04292%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/COMPETE/PTDC%2FAGR-PRO%2F3496%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/FARH/SFRH%2FBD%2F98266%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBPD%2F94500%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F110943%2F2015/PT
oaire.citation.endPage854pt_PT
oaire.citation.startPage845pt_PT
oaire.citation.titleEnvironmental Pollutionpt_PT
oaire.citation.volume246pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamCOMPETE
oaire.fundingStreamFARH
oaire.fundingStreamSFRH
person.familyNameSimões
person.familyNameNovais
person.familyNameLemos
person.givenNameTiago
person.givenNameSara
person.givenNameMarco
person.identifier996337
person.identifier.ciencia-id0D1D-8D1A-A883
person.identifier.ciencia-id2216-A2E0-A118
person.identifier.orcid0000-0002-6107-9790
person.identifier.orcid0000-0003-1306-3396
person.identifier.orcid0000-0001-9887-1864
person.identifier.ridA-9032-2012
person.identifier.ridF-7951-2011
person.identifier.scopus-author-id16302507900
person.identifier.scopus-author-id23025463300
person.identifier.scopus-author-id7006042884
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.cv.cienciaid971F-ACCA-C0D1 | Marco Lemos
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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