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Optimal nitrate supplementation in Phaeodactylum tricornutum culture medium increases biomass and fucoxanthin production

2022Journal article Open access
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dc.contributor.authorAfonso, Clélia
dc.contributor.authorBragança, Ana Rita
dc.contributor.authorRebelo, Bárbara A.
dc.contributor.authorSerra, Tânia S.
dc.contributor.authorAbranches, Rita
dc.date.accessioned2022-07-22T13:07:05Z
dc.date.available2022-07-22T13:07:05Z
dc.date.issued2022
dc.description.abstractPhaeodactylum tricornutum is a model diatom with numerous potential applications in the industry, including the production of high-value carotenoid pigments such as fucoxanthin. This compound is a potent antioxidant currently extracted mainly from brown macroalgae. Fucoxanthin exhibits several biological properties with well-known beneficial effects in the treatment and prevention of lifestyle-related diseases. P. tricornutum offers a valuable alternative to macroalgae for fucoxanthin production as it has a specific productivity that is 10-fold higher as compared with macroalgae. However, production processes still need to be optimised to become a cost-effective alternative. In this work, we investigated the optimal supplementation of nitrate in a cultivation medium that is currently used for P. tricornutum and how this nitrate concentration affects cell growth and fucoxanthin production. It has previously been shown that the addition of sodium nitrate increases productivity, but optimal conditions were not accurately determined. In this report, we observed that the continuous increase in nitrate concentration did not lead to an increase in biomass and fucoxanthin content, but there was rather a window of optimal values of nitrate that led to maximum growth and pigment production. These results are discussed considering both the scale up for industrial production and the profitability of the process, as well as the implications in the cell's metabolism and effects in fucoxanthin production.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAfonso C, Bragança AR, Rebelo BA, Serra TS, Abranches R. Optimal Nitrate Supplementation in Phaeodactylum tricornutum Culture Medium Increases Biomass and Fucoxanthin Production. Foods. 2022 Feb 16;11(4):568. doi: 10.3390/foods11040568. PMID: 35206051; PMCID: PMC8871257.pt_PT
dc.identifier.doi10.3390/foods11040568pt_PT
dc.identifier.issn2304-8158
dc.identifier.urihttp://hdl.handle.net/10400.8/7403
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationGREEN-IT "Bioresources for Sustainability"
dc.relationMarine and Environmental Sciences Centre
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCarotenoidpt_PT
dc.subjectFucoxanthin optimisationpt_PT
dc.subjectMicroalgaept_PT
dc.subjectModel diatompt_PT
dc.subjectNitrate supplementationpt_PT
dc.titleOptimal nitrate supplementation in Phaeodactylum tricornutum culture medium increases biomass and fucoxanthin productionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleGREEN-IT "Bioresources for Sustainability"
oaire.awardTitleMarine and Environmental Sciences Centre
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04551%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04292%2F2020/PT
oaire.citation.issue4pt_PT
oaire.citation.titleFoodspt_PT
oaire.citation.volume11pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameAfonso
person.familyNameda Silva Bragança
person.familyNameRebelo
person.familyNameSobral Moutinho Abranches
person.givenNameClélia
person.givenNameAna Rita
person.givenNameBárbara A.
person.givenNameRita
person.identifier153274
person.identifier.ciencia-idC512-13C3-50DD
person.identifier.ciencia-idFA17-AC9E-2FD8
person.identifier.ciencia-idF51B-51D5-C74E
person.identifier.ciencia-id161C-64DE-D005
person.identifier.orcid0000-0002-4167-5237
person.identifier.orcid0000-0002-8004-6708
person.identifier.orcid0000-0003-3771-1482
person.identifier.orcid0000-0003-3173-3701
person.identifier.ridB-1211-2016
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication6068b5f7-a677-4a4a-9bf9-15f64fa002c3
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relation.isAuthorOfPublication1efd78cd-ea5c-4b6f-830f-22270e2618d9
relation.isAuthorOfPublication.latestForDiscovery4876cc93-8744-4885-ae53-7b552036195d
relation.isProjectOfPublication9621f90c-86a3-413c-bff9-07a76fbb20e9
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