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Biomaterials for In Situ Tissue Regeneration: A Review

2019-11-19Journal article Open access
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dc.contributor.authorAbdulghani, Saba
dc.contributor.authorMitchell, Geoffrey R.
dc.date.accessioned2023-04-05T15:54:09Z
dc.date.available2023-04-05T15:54:09Z
dc.date.issued2019-11-19
dc.descriptionFunding: This research was funded by FCT (Portugal), grant number POCI-01-0145-FEDER-031146.pt_PT
dc.description.abstractThis review focuses on a somewhat unexplored strand of regenerative medicine, that is in situ tissue engineering. In this approach manufactured scaffolds are implanted in the injured region for regeneration within the patient. The scaffold is designed to attract cells to the required volume of regeneration to subsequently proliferate, differentiate, and as a consequence develop tissue within the scaffold which in time will degrade leaving just the regenerated tissue. This review highlights the wealth of information available from studies of ex-situ tissue engineering about the selection of materials for scaffolds. It is clear that there are great opportunities for the use of additive manufacturing to prepare complex personalized scaffolds and we speculate that by building on this knowledge and technology, the development of in situ tissue engineering could rapidly increase. Ex-situ tissue engineering is handicapped by the need to develop the tissue in a bioreactor where the conditions, however optimized, may not be optimum for accelerated growth and maintenance of the cell function. We identify that in both methodologies the prospect of tissue regeneration has created much promise but delivered little outside the scope of laboratory-based experiments. We propose that the design of the scaffolds and the materials selected remain at the heart of developments in this field and there is a clear need for predictive modelling which can be used in the design and optimization of materials and scaffolds.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAbdulghani S, Mitchell GR. Biomaterials for In Situ Tissue Regeneration: A Review. Biomolecules. 2019 Nov 19;9(11):750. doi: 10.3390/biom9110750. PMID: 31752393; PMCID: PMC6920773.pt_PT
dc.identifier.doi10.3390/biom9110750pt_PT
dc.identifier.eissn2218-273X
dc.identifier.other750
dc.identifier.otherPMC6920773
dc.identifier.pmid31752393
dc.identifier.urihttp://hdl.handle.net/10400.8/8338
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherPubmed - ncbipt_PT
dc.relationPOCI-01-0145-FEDER-031146pt_PT
dc.relation.publisherversionhttps://pubmed.ncbi.nlm.nih.gov/31752393/pt_PT
dc.subjectIn situ tissue engineeringpt_PT
dc.subjectBiomaterialspt_PT
dc.subjectNatural polymerspt_PT
dc.subjectSynthetic polymerspt_PT
dc.titleBiomaterials for In Situ Tissue Regeneration: A Reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage24pt_PT
oaire.citation.issue11pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleBiomoleculespt_PT
oaire.citation.volume9pt_PT
person.familyNameMitchell
person.givenNameGeoffrey
person.identifier166356
person.identifier.ciencia-idE41A-ABDD-1FC7
person.identifier.orcid0000-0001-7977-7610
person.identifier.scopus-author-id7403103397
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication48c8066b-023e-4405-b462-49d28af000d1
relation.isAuthorOfPublication.latestForDiscovery48c8066b-023e-4405-b462-49d28af000d1

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