From animal to human: (Re)using acellular extracellular matrices for temporomandibular disc substitution

Trindade, Daniela; Alves, Nuno; Moura, Carla

http://hdl.handle.net/10400.8/8154

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Authors

Trindade, Daniela

Alves, Nuno

Moura, Carla

Abstract(s)

Current treatments for temporomandibular joint (TMJ) disc dysfunctions are not fully effective and lack regenerative capacity. Therefore, the search for tissue-engineered materials for TMJ disc substitution is critical to fill this gap. Decellularization presents tremendous potential, as it is possible to obtain an extracellular matrix with an adequate biomechanical structure and biochemical components. However, its application to the TMJ disc is still in progress, since there are few studies in the literature, and those that exist have many gaps in terms of characterisation, which is decisive to ensure its success. Ultimately, we intend to emphasize the importance of the decellularization technique for the development of an engineered TMJ disc.

Keywords

Temporomandibular disc Decellularization Extracellular matrix

URI

http://hdl.handle.net/10400.8/8154

Citation

Trindade, D.; Alves, N.; Moura, C. From Animal to Human: (Re)using Acellular Extracellular Matrices for Temporomandibular Disc Substitution. J. Funct. Biomater. 2022, 13, 61. https://doi.org/ 10.3390/jfb13020061