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Numerical Calculations in Tissue Engineering

2014-05Conference paper Open access
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datacite.subject.fosEngenharia e Tecnologia::Outras Engenharias e Tecnologias
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
datacite.subject.sdg12:Produção e Consumo Sustentáveis
dc.contributor.authorAlmeida, Henrique de Amorim
dc.contributor.authorBártolo, Paulo J.
dc.date.accessioned2025-06-27T17:02:45Z
dc.date.available2025-06-27T17:02:45Z
dc.date.issued2014-05
dc.description1st International Conference on Progress in Additive Manufacturing, Pro-AM 2014 - Code 129094
dc.description.abstractThe design of optimized scaffolds for tissue engineering is a key topic of research, as the complex macro- and micro- architectures required for a scaffold depends not only on the mechanical properties, but also on the physical and molecular queues of the surrounding tissue within the defect site. Thus, the prediction of optimal features for tissue engineering scaffolds is very important for its mechanical, vascular or topological properties. The relationship between high scaffold porosity and high mechanical properties is contradictory, as it becomes even more complex due to the scaffold degradation process. A scaffold design strategy was developed, based on the finite element method, to optimise the scaffold design regarding the mechanical and vascular properties as a function of porosity. Scaffolds can be considered as a LEGO structure formed by an association of small elementary units or blocks. In this research work, two types of family elementary scaffold units were considered: non-triple periodic minimal surfaces and triple periodic minimal surfaces that describe natural existing surfaces. The main objective of this work is to present the undergoing research based on numerical simulations for the evaluation and prediction of the scaffold's behaviour under structural and vascular loading, and its topological optimisation.eng
dc.description.sponsorshipThis research is supported by the Portuguese Foundation of Science and Technology through a PhD grant of Henrique Almeida (SFRH/BD/37604/2007). Authors also acknowledge the support of the FCT (Strategic Project PEST-OE/EME/UI4044/2013) and the European Commission (IREBID Marie Curie Project).
dc.identifier.citationAlmeida, H. A., & Bártolo, P. J. (2014). Numerical Calculations in Tissue Engineering. Proceedings of the 1st International Conference on Progress in Additive Manufacturing (Pro‑AM 2014), 53‑59. DOI: https://doi.org/10.3850/978-981-09-0446-3_094.
dc.identifier.doi10.3850/978-981-09-0446-3_094
dc.identifier.isbn978-981090446-3
dc.identifier.issn24248967
dc.identifier.urihttp://hdl.handle.net/10400.8/13454
dc.language.isoeng
dc.peerreviewedyes
dc.publisherPro-AM
dc.relationPROJECTO INTELIGENTE DE SCAFFOLDS OBTIDOS POR PROTOTIPAGEM RÁPIDA
dc.relationStrategic Project - UI 4044 - 2013-2014
dc.relation.hasversionhttps://rpsonline.com.sg/proceedings/9789810904456/html/094.xml
dc.relation.ispartofProceedings of the 1st International Conference on Progress in Additive Manufacturing
dc.rights.uriN/A
dc.subjectAdditives
dc.subjectBiomechanics
dc.subjectComputer architecture
dc.subjectEngineering research
dc.subjectManufacture
dc.subjectMechanical properties
dc.subjectPorosity
dc.subjectTissue
dc.subjectTopology
dc.titleNumerical Calculations in Tissue Engineeringeng
dc.typeconference paper
dspace.entity.typePublication
oaire.awardTitlePROJECTO INTELIGENTE DE SCAFFOLDS OBTIDOS POR PROTOTIPAGEM RÁPIDA
oaire.awardTitleStrategic Project - UI 4044 - 2013-2014
oaire.awardURIhttp://hdl.handle.net/10400.8/13226
oaire.awardURIhttp://hdl.handle.net/10400.8/13452
oaire.citation.conferenceDate2014-05
oaire.citation.conferencePlaceSingapore
oaire.citation.endPage59
oaire.citation.startPage53
oaire.citation.titleProceedings of the International Conference on Progress in Additive Manufacturing
oaire.fundingStreamPIDDAC
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameAlmeida
person.givenNameHenrique de Amorim
person.identifier46395
person.identifier.ciencia-id8F1D-4370-84BE
person.identifier.orcid0000-0002-1367-2290
person.identifier.ridD-6275-2012
person.identifier.scopus-author-id55938867800
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The design of optimized scaffolds for tissue engineering is a key topic of research, as the complex macro- and micro- architectures required for a scaffold depends not only on the mechanical properties, but also on the physical and molecular queues of the surrounding tissue within the defect site. Thus, the prediction of optimal features for tissue engineering scaffolds is very important for its mechanical, vascular or topological properties. The relationship between high scaffold porosity and high mechanical properties is contradictory, as it becomes even more complex due to the scaffold degradation process. A scaffold design strategy was developed, based on the finite element method, to optimise the scaffold design regarding the mechanical and vascular properties as a function of porosity. Scaffolds can be considered as a LEGO structure formed by an association of small elementary units or blocks. In this research work, two types of family elementary scaffold units were considered: non-triple periodic minimal surfaces and triple periodic minimal surfaces that describe natural existing surfaces. The main objective of this work is to present the undergoing research based on numerical simulations for the evaluation and prediction of the scaffold's behaviour under structural and vascular loading, and its topological optimisation.
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