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Current Strategies to Produce 3D Electrospun-Based Wound Dressings for Skin Regeneration

2025-07-02Artigo de revisão Acesso aberto
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datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.fosEngenharia e Tecnologia::Engenharia dos Materiais
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorFerreira, Carolina A. M.
dc.contributor.authorLemos, Marco F. L.
dc.contributor.authorMaurício, Ana Colette
dc.contributor.authorDias, Juliana R.
dc.date.accessioned2026-09-08T16:43:21Z
dc.date.available2026-09-08T16:43:21Z
dc.date.issued2025-07-02
dc.date.updated2026-09-02T15:56:15Z
dc.description.abstractTissue engineering-based wound dressings are a promising treatment approach that mimics the native skin microenvironment to promote effective healing and tissue regeneration. In fact, those advanced wound dressings can be made by electrospinning which has revolutionized the field of wound healing by developing biostructures that closely mimic the skin’s extracellular matrix (ECM). To date, most electrospinning research has focused on composition and materials rather than exploring advanced deposition strategies. Conventional electrospinning using random, aligned fibers, co-electrospinning, core-shell approaches, or redesigned collectors has achieved significant results in wound healing, which are discussed in this article. However, these approaches lack the development of realistic 3D structures. To achieve that, advancing approaches through the combination of electrospinning with different techniques such as gas foaming, short nanofiber assembly, or 3D printing significantly enhance skin regeneration of deep wounds (full-thickness and chronic wounds) compared to 2D structures. This review highlights the latest developments, design principles, and recent breakthroughs in electrospinning structures for skin regeneration and provides a fresh perspective for upcoming research in the field of 3D electrospun-based structures.eng
dc.description.sponsorshipFunding This work was financially supported by Fundac¸~ao para a Ci^encia e Tecnologia, I. P (FCT) through the grant awarded to Carolina Ferreira [2021.04541.BD], identified by https://doi.org/10.54499/2021.04541.BD, and the funding to Juliana Dias (10.54499/CEECINST/00060/2021/CP2902/CT0005). FCT/MCTES (PIDDAC) also contributed financially through the following Projects: UIDB/04044/2020; UIDP/04044/2020; Associate Laboratory ARISE LA/P/0112/2020; PTCentroDiH (03/C16-i03/2022-768), “OP-SMARTherapy, 2022.04238.PTDC”, “InnovaBIOMAS, [2022.10564.PTDC]. FCT supported this work under the projects UID/04292/MARE-Centro de Ci^encias do Mar e do Ambiente, and LA/P/0069/2020 granted to the Associate Laboratory ARNET. This study was also supported by INOV.AM – Inovac¸~ao em Fabricac¸~ao Aditiva [02-C05-i01.01-2022], Nanofilm (CENTRO2030-FEDER-01469100) and by European Union through PREDICTOS “PREDICTOS, 101079372” and Project Interreg EAPA-0032/2022 – BEAP-MAR.
dc.description.versionN/A
dc.identifier.citationFerreira, C. A. M., Lemos, M. F. L., Maurício, A. C., & Dias, J. R. (2025). Current strategies to produce 3D electrospun-based wound dressings for skin regeneration. Polymer Reviews, 65(4), 1150–1185. https://doi.org/10.1080/15583724.2025.2524625
dc.identifier.doi10.1080/15583724.2025.2524625en_US
dc.identifier.eid2-s2.0-105009543325en_US
dc.identifier.eissn1558-3716
dc.identifier.issn1558-3724
dc.identifier.slugcv-prod-4753773
dc.identifier.urihttp://hdl.handle.net/10400.8/16818
dc.language.isoeng
dc.peerreviewedyes
dc.publisherTaylor & Francis
dc.relationSeaweeds polyphenolic bioactive extracts as a potential source for incorporating in multi-fiber orientation electrospun meshes for chronic wound healing applications: Diabetic ulcers
dc.relationCentre for Rapid and Sustainable Product Development
dc.relationCentre for Rapid and Sustainable Product Development
dc.relationAdvanced Production and Intelligent Systems
dc.relationStimuli-responsive bone-like magnetic scaffolds with osteoimmunomodulatory effect for prevention of osteoporosis related fractures
dc.relationOptimised additive biomanufacturing system to produce hierarchical multi-tissue scaffolds for the treatment of joint diseases
dc.relationMARE - Marine and Environmental Sciences Centre
dc.relationAquatic Research Infrastructure Network
dc.relationStrengthening excellence for advanced osteosarcoma’s predictive models
dc.relation.hasversionhttps://www.tandfonline.com/doi/full/10.1080/15583724.2025.2524625
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject3D structures
dc.subjectchronic wound
dc.subjectElectrospinning
dc.subjectFull-Thickness wound
dc.subjectwound healing
dc.titleCurrent Strategies to Produce 3D Electrospun-Based Wound Dressings for Skin Regenerationeng
dc.typereview article
dspace.entity.typePublication
oaire.awardNumber2021.04541.BD
oaire.awardNumberUIDB/04044/2020
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oaire.awardTitleSeaweeds polyphenolic bioactive extracts as a potential source for incorporating in multi-fiber orientation electrospun meshes for chronic wound healing applications: Diabetic ulcers
oaire.awardTitleCentre for Rapid and Sustainable Product Development
oaire.awardTitleCentre for Rapid and Sustainable Product Development
oaire.awardTitleAdvanced Production and Intelligent Systems
oaire.awardTitleStimuli-responsive bone-like magnetic scaffolds with osteoimmunomodulatory effect for prevention of osteoporosis related fractures
oaire.awardTitleOptimised additive biomanufacturing system to produce hierarchical multi-tissue scaffolds for the treatment of joint diseases
oaire.awardTitleMARE - Marine and Environmental Sciences Centre
oaire.awardTitleAquatic Research Infrastructure Network
oaire.awardTitleStrengthening excellence for advanced osteosarcoma’s predictive models
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_CENTRO/2021.04541.BD/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04044%2F2020/PT
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oaire.awardURIhttp://hdl.handle.net/10400.8/16812
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oaire.citation.endPage1185
oaire.citation.issue4en_US
oaire.citation.startPage1150
oaire.citation.titlePolymer Reviewsen_US
oaire.citation.volume65en_US
oaire.fundingStreamPOR_CENTRO
oaire.fundingStream6817 - DCRRNI ID
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oaire.fundingStreamConcurso de Projetos de I&D em Todos os Domínios Científicos - 2022 - PEX
oaire.fundingStream3599-PPCDT
oaire.fundingStreamFinanciamento do Plano Estratégico de Unidades de I&D - 2013/2015 - OE
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oaire.fundingStreamHORIZON Action Grant Budget-Based
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person.familyNameMarzia Ferreira
person.familyNameLemos
person.familyNameDias
person.givenNameCarolina Alexandra
person.givenNameMarco
person.givenNameJuliana
person.identifier996337
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person.identifier.ciencia-id0612-D971-F00D
person.identifier.orcid0000-0002-6838-3744
person.identifier.orcid0000-0001-9887-1864
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person.identifier.ridF-7951-2011
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project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
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rcaap.cv.cienciaid0612-D971-F00D | Juliana Rosa Dias
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