Mesoporous silica nanoparticles with manganese and lanthanide salts: synthesis, characterization and cytotoxicity studies

Forte, Andreia; Gago, Sandra; Carrott, Manuela Ribeiro; Carrott, Peter; Alves, Celso; Teodoro, Fernando; Pedrosa, Rui; Marrucho, Isabel M.; Branco, Luis C

http://hdl.handle.net/10400.8/5998

Utilize este identificador para referenciar este registo.

Nome:	Descrição:	Tamanho:	Formato:
d1dt00605c.pdf		4.39 MB	Adobe PDF	Ver/Abrir

Contacte-nos

Autores

Forte, Andreia

Gago, Sandra

Carrott, Manuela Ribeiro

Resumo(s)

Several organic salts based on the combination of two different choline derivative cations and MnCl3−, GdCl4− and TbCl4− as anions were immobilized in mesoporous silica nanoparticles (MSNs) by a two-step synthetic method. Firstly, MSNs were functionalized with choline derivative cations with chloride anions and then the metals were incorporated by the reaction of the chloride with the respective metal chloride salts. These nanomaterials were fully characterized by different characterization techniques such as 1H-NMR, FT-IR, elemental analysis, TEM, TGA, N2 adsorption, XRD and DLS. These characterization data were important to confirm the successful functionalization of the nanomaterials and to access their textural properties and colloidal stability. The final materials were also characterized by ICP-MS that indicated the metal contents. The cytotoxicity profile was evaluated in four different cell lines (3T3, 293T, HepG2 and Caco-2), which shows some relevant differences between the metal organic salts and their immobilized analogues.

Descrição

This work was supported by National Funds through FCT/ MCTES – Portuguese Foundation for Science and Technology within the scope of the projects UID/QUI/0619/2019, UIDB/ 50006/2020 (LAQV-REQUIMTE) and UIDB/00100/2020, UID/ MAR/04292/2020 (MARE—Marine and Environmental Sciences Centre). Also, a doctoral fellowship to Andreia Forte (PD/BD/ 109625/2015) and Solchemar company are acknowledged. The NMR spectrometers are part of The National NMR Facility, supported by FCT/MCTES (RECI/BBB-BQB/0230/2012).

URI

http://hdl.handle.net/10400.8/5998

Citação

Andreia Forte; Sandra Gago; Manuela Ribeiro Carrott; Peter Carrott; Celso Alves; Fernando Teodoro; Rui Pedrosa; Isabel M. Marrucho; Luis C. Branco. "Mesoporous silica nanoparticles with manganese and lanthanide salts: synthesis, characterization and cytotoxicity studies". Dalton Transactions (2021): https://doi.org/10.1039/D1DT00605C.