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Advanced Biofabrication Strategies for Skin Regeneration and Repair

2013-04Artigo científico Acesso restrito
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datacite.subject.fosEngenharia e Tecnologia::Biotecnologia Industrial
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
datacite.subject.sdg12:Produção e Consumo Sustentáveis
dc.contributor.authorPereira, Rúben F.
dc.contributor.authorBarrias, Cristina C
dc.contributor.authorGranja, Pedro L
dc.contributor.authorBártolo, Paulo J.
dc.date.accessioned2026-04-17T16:37:20Z
dc.date.available2026-04-17T16:37:20Z
dc.date.issued2013-04
dc.description.abstractSkin is the largest organ of human body, acting as a barrier with protective, immunologic and sensorial functions. Its permanent exposure to the external environment can result in different kinds of damage with loss of variable volumes of extracellular matrix. For the treatment of skin lesions, several strategies are currently available, such as the application of autografts, allografts, wound dressings and tissue-engineered substitutes. Although proven clinically effective, these strategies are still characterized by key limitations such as patient morbidity, inadequate vascularization, low adherence to the wound bed, the inability to reproduce skin appendages and high manufacturing costs. Advanced strategies based on both bottom-up and top-down approaches offer an effective, permanent and viable alternative to solve the abovementioned drawbacks by combining biomaterials, cells, growth factors and advanced biomanufacturing techniques. This review details recent advances in skin regeneration and repair strategies, and describes their major advantages and limitations. Future prospects for skin regeneration are also outlined.eng
dc.description.sponsorshipThe authors are supported by the Strategic Projects PEST-OE/EME/UI4044/2011 and PEST-C/SAU/LA0002/2011, and financed by European Regional Development Fund through the Programa Operacional Factores de Competitividade – COMPETE and by Portuguese funds through Fundação para a Ciência e a Tecnologia. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
dc.identifier.citationPereira, R. F., Barrias, C. C., Granja, P. L., & Bartolo, P. J. (2013). Advanced Biofabrication Strategies for Skin Regeneration and Repair. Nanomedicine, 8(4), 603–621. https://doi.org/10.2217/nnm.13.50
dc.identifier.doi10.2217/nnm.13.50
dc.identifier.issn1743-5889
dc.identifier.issn1748-6963
dc.identifier.urihttp://hdl.handle.net/10400.8/16148
dc.language.isoeng
dc.peerreviewedyes
dc.publisherInforma
dc.relationStrategic Project - UI 4044 - 2011-2012
dc.relation.hasversionhttps://www.tandfonline.com/doi/full/10.2217/nnm.13.50
dc.relation.ispartofNanomedicine
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectBottom-up approach
dc.subjectIn situ biofabrication
dc.subjectNanoscale structure
dc.subjectSkin regeneration
dc.subjectTissue engineering
dc.subjectTop-down approach
dc.subjectWound healing
dc.titleAdvanced Biofabrication Strategies for Skin Regeneration and Repaireng
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberPEst-OE/EME/UI4044/2011
oaire.awardTitleStrategic Project - UI 4044 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FEME%2FUI4044%2F2011/PT
oaire.citation.endPage621
oaire.citation.issue4
oaire.citation.startPage603
oaire.citation.titleNanomedicine
oaire.citation.volume8
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameBrás Pereira
person.familyNameBartolo
person.givenNameRúben Filipe
person.givenNamePaulo
person.identifier1337969
person.identifier203086
person.identifier.ciencia-id9417-153E-4473
person.identifier.ciencia-id5810-9BF9-4522
person.identifier.orcid0000-0002-7255-3400
person.identifier.orcid0000-0003-3683-726X
person.identifier.ridP-8503-2018
person.identifier.ridF-2421-2013
person.identifier.scopus-author-id55421048100
person.identifier.scopus-author-id6603353041
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isAuthorOfPublicationeda35774-59b3-4801-aa88-9c20f4c31a78
relation.isAuthorOfPublicationab44d1ae-46d0-45c2-b19f-200024b5a990
relation.isAuthorOfPublication.latestForDiscoveryeda35774-59b3-4801-aa88-9c20f4c31a78
relation.isProjectOfPublication44bd1c93-9ee1-4685-a408-c2baa61ffbcd
relation.isProjectOfPublication.latestForDiscovery44bd1c93-9ee1-4685-a408-c2baa61ffbcd

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