Publication
Corncob cellulose scaffolds: A new sustainable temporary implant for cartilage replacement
dc.contributor.author | Cordeiro, Rachel | |
dc.contributor.author | Henriques, Marta | |
dc.contributor.author | Silva, João C. | |
dc.contributor.author | Antunes, Filipe | |
dc.contributor.author | Alves, Nuno | |
dc.contributor.author | Moura, Carla | |
dc.date.accessioned | 2023-02-23T15:24:24Z | |
dc.date.available | 2023-02-23T15:24:24Z | |
dc.date.issued | 2022 | |
dc.description.abstract | Tissue engineering using scaffolds is a promising strategy to repair damaged articular cartilage, whose self-repair is inefficient. Cellulose properties have been recognized for their application in the biomedical field. The aim of this study was to fabricate and characterize novel scaffolds based on poly(E-caprolactone) (PCL) and sustainable cellulose. Thus, the performance of corncob-derived cellulose (CC) in scaffolds as an alternative to wood cellulose (WC) was also investigated to reduce the environmental footprint. Two concentrations of CC in scaffolds were tested, 1% and 2% (w/w), and commercial WC using the same concentrations, as a control. Morphologically, all the developed scaffolds presented pore sizes of ~300 m, 10 layers, a circular shape and well-dispersed cellulose. Thus, all of these characteristics and properties provide the manufactured scaffolds suitable for use in cartilage-replacement strategies. The use of 2% CC results in higher porosity (54.24%), which promotes cell infiltration/migration and nutrient exchange, and has similar mechanical properties to WC. As for the effects of enzymatic degradation of the scaffolds, no significant changes (p > 0.05) were observed in resistance over time. However, the obtained compressive modulus of the scaffold with 2% CC was similar to that of WC. Overall, our results suggest that the integration of 2% corncob cellulose in PCL scaffolds could be a novel way to replace wood-cellulose-containing scaffolds, highlighting its potential for cartilage-replacement strategies. | pt_PT |
dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
dc.identifier.citation | Cordeiro, R.; Henriques, M.; Silva, J.C.; Antunes, F.; Alves, N.; Moura, C. Corncob Cellulose Scaffolds: A New Sustainable Temporary Implant for Cartilage Replacement. J. Funct. Biomater. 2022, 13, 63. https://doi.org/10.3390/ jfb13020063 | pt_PT |
dc.identifier.doi | 10.3390/ jfb13020063 | pt_PT |
dc.identifier.issn | 2079-4983 | |
dc.identifier.uri | http://hdl.handle.net/10400.8/8156 | |
dc.language.iso | eng | pt_PT |
dc.peerreviewed | yes | pt_PT |
dc.publisher | MDPI | pt_PT |
dc.relation | ARISE LA/P/0112/ 2020 | pt_PT |
dc.relation | Centre for Rapid and Sustainable Product Development | |
dc.relation | Centre for Rapid and Sustainable Product Development | |
dc.relation | Institute for Bioengineering and Biosciences | |
dc.relation | Institute for Bioengineering and Biosciences | |
dc.relation.publisherversion | https://www.mdpi.com/2079-4983/13/2/63 | pt_PT |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | pt_PT |
dc.subject | Cartilage repair | pt_PT |
dc.subject | Corncob cellulose | pt_PT |
dc.subject | Scaffold | pt_PT |
dc.subject | Tissue engineering | pt_PT |
dc.subject | Sustainability | pt_PT |
dc.title | Corncob cellulose scaffolds: A new sustainable temporary implant for cartilage replacement | pt_PT |
dc.type | journal article | |
dspace.entity.type | Publication | |
oaire.awardTitle | Centre for Rapid and Sustainable Product Development | |
oaire.awardTitle | Centre for Rapid and Sustainable Product Development | |
oaire.awardTitle | Institute for Bioengineering and Biosciences | |
oaire.awardTitle | Institute for Bioengineering and Biosciences | |
oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04044%2F2020/PT | |
oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04044%2F2020/PT | |
oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04565%2F2020/PT | |
oaire.awardURI | info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04565%2F2020/PT | |
oaire.citation.issue | 2 | pt_PT |
oaire.citation.title | Journal of Functional Biomaterials | pt_PT |
oaire.citation.volume | 13 | pt_PT |
oaire.fundingStream | 6817 - DCRRNI ID | |
oaire.fundingStream | 6817 - DCRRNI ID | |
oaire.fundingStream | 6817 - DCRRNI ID | |
oaire.fundingStream | 6817 - DCRRNI ID | |
person.familyName | Cordeiro | |
person.familyName | Henriques | |
person.familyName | Silva | |
person.familyName | Alves | |
person.familyName | Monteiro de Moura | |
person.givenName | Rachel | |
person.givenName | Marta Helena Fernandes | |
person.givenName | João Carlos | |
person.givenName | Nuno | |
person.givenName | Carla Sofia | |
person.identifier | PCP-2MEAAAAJ&hl=pt-PT | |
person.identifier | H-4029-2019 | |
person.identifier | 1715750 | |
person.identifier | 452149 | |
person.identifier.ciencia-id | 6A15-D2F9-9962 | |
person.identifier.ciencia-id | 401F-3B59-CFC0 | |
person.identifier.ciencia-id | 7F1B-FF18-FBAA | |
person.identifier.ciencia-id | 311E-1559-8F6C | |
person.identifier.ciencia-id | 671C-8FEC-A14A | |
person.identifier.orcid | 0000-0001-8217-8600 | |
person.identifier.orcid | 0000-0001-9214-0614 | |
person.identifier.orcid | 0000-0003-4773-6771 | |
person.identifier.orcid | 0000-0002-5016-0868 | |
person.identifier.orcid | 0000-0003-2610-1005 | |
person.identifier.rid | N-4073-2013 | |
person.identifier.scopus-author-id | 7006664977 | |
person.identifier.scopus-author-id | 57214120948 | |
person.identifier.scopus-author-id | 7006403383 | |
project.funder.identifier | http://doi.org/10.13039/501100001871 | |
project.funder.identifier | http://doi.org/10.13039/501100001871 | |
project.funder.identifier | http://doi.org/10.13039/501100001871 | |
project.funder.identifier | http://doi.org/10.13039/501100001871 | |
project.funder.name | Fundação para a Ciência e a Tecnologia | |
project.funder.name | Fundação para a Ciência e a Tecnologia | |
project.funder.name | Fundação para a Ciência e a Tecnologia | |
project.funder.name | Fundação para a Ciência e a Tecnologia | |
rcaap.rights | openAccess | pt_PT |
rcaap.type | article | pt_PT |
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