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Corncob cellulose scaffolds: A new sustainable temporary implant for cartilage replacement

dc.contributor.authorCordeiro, Rachel
dc.contributor.authorHenriques, Marta
dc.contributor.authorSilva, João C.
dc.contributor.authorAntunes, Filipe
dc.contributor.authorAlves, Nuno
dc.contributor.authorMoura, Carla
dc.date.accessioned2023-02-23T15:24:24Z
dc.date.available2023-02-23T15:24:24Z
dc.date.issued2022
dc.description.abstractTissue engineering using scaffolds is a promising strategy to repair damaged articular cartilage, whose self-repair is inefficient. Cellulose properties have been recognized for their application in the biomedical field. The aim of this study was to fabricate and characterize novel scaffolds based on poly(E-caprolactone) (PCL) and sustainable cellulose. Thus, the performance of corncob-derived cellulose (CC) in scaffolds as an alternative to wood cellulose (WC) was also investigated to reduce the environmental footprint. Two concentrations of CC in scaffolds were tested, 1% and 2% (w/w), and commercial WC using the same concentrations, as a control. Morphologically, all the developed scaffolds presented pore sizes of ~300 m, 10 layers, a circular shape and well-dispersed cellulose. Thus, all of these characteristics and properties provide the manufactured scaffolds suitable for use in cartilage-replacement strategies. The use of 2% CC results in higher porosity (54.24%), which promotes cell infiltration/migration and nutrient exchange, and has similar mechanical properties to WC. As for the effects of enzymatic degradation of the scaffolds, no significant changes (p > 0.05) were observed in resistance over time. However, the obtained compressive modulus of the scaffold with 2% CC was similar to that of WC. Overall, our results suggest that the integration of 2% corncob cellulose in PCL scaffolds could be a novel way to replace wood-cellulose-containing scaffolds, highlighting its potential for cartilage-replacement strategies.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCordeiro, R.; Henriques, M.; Silva, J.C.; Antunes, F.; Alves, N.; Moura, C. Corncob Cellulose Scaffolds: A New Sustainable Temporary Implant for Cartilage Replacement. J. Funct. Biomater. 2022, 13, 63. https://doi.org/10.3390/ jfb13020063pt_PT
dc.identifier.doi10.3390/ jfb13020063pt_PT
dc.identifier.issn2079-4983
dc.identifier.urihttp://hdl.handle.net/10400.8/8156
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationARISE LA/P/0112/ 2020pt_PT
dc.relationCentre for Rapid and Sustainable Product Development
dc.relationCentre for Rapid and Sustainable Product Development
dc.relationInstitute for Bioengineering and Biosciences
dc.relationInstitute for Bioengineering and Biosciences
dc.relation.publisherversionhttps://www.mdpi.com/2079-4983/13/2/63pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectCartilage repairpt_PT
dc.subjectCorncob cellulosept_PT
dc.subjectScaffoldpt_PT
dc.subjectTissue engineeringpt_PT
dc.subjectSustainabilitypt_PT
dc.titleCorncob cellulose scaffolds: A new sustainable temporary implant for cartilage replacementpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre for Rapid and Sustainable Product Development
oaire.awardTitleCentre for Rapid and Sustainable Product Development
oaire.awardTitleInstitute for Bioengineering and Biosciences
oaire.awardTitleInstitute for Bioengineering and Biosciences
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04044%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04044%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04565%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04565%2F2020/PT
oaire.citation.issue2pt_PT
oaire.citation.titleJournal of Functional Biomaterialspt_PT
oaire.citation.volume13pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameCordeiro
person.familyNameHenriques
person.familyNameSilva
person.familyNameAlves
person.familyNameMonteiro de Moura
person.givenNameRachel
person.givenNameMarta Helena Fernandes
person.givenNameJoão Carlos
person.givenNameNuno
person.givenNameCarla Sofia
person.identifierPCP-2MEAAAAJ&hl=pt-PT
person.identifierH-4029-2019
person.identifier1715750
person.identifier452149
person.identifier.ciencia-id6A15-D2F9-9962
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person.identifier.ciencia-id311E-1559-8F6C
person.identifier.ciencia-id671C-8FEC-A14A
person.identifier.orcid0000-0001-8217-8600
person.identifier.orcid0000-0001-9214-0614
person.identifier.orcid0000-0003-4773-6771
person.identifier.orcid0000-0002-5016-0868
person.identifier.orcid0000-0003-2610-1005
person.identifier.ridN-4073-2013
person.identifier.scopus-author-id7006664977
person.identifier.scopus-author-id57214120948
person.identifier.scopus-author-id7006403383
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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