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Differential Modulation of Cancellous and Cortical Distal Femur by Fructose and Natural Mineral-Rich Water Consumption in Ovariectomized Female Sprague Dawley Rats

2019-09-30Journal article Open access
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datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorDavid Guede
dc.contributor.authorCecília Durães
dc.contributor.authorInês Brandão
dc.contributor.authorNuno Silva
dc.contributor.authorEmanuel Passos
dc.contributor.authorMiguel Bernardes
dc.contributor.authorRosário Monteiro
dc.contributor.authorMaria João Martins
dc.contributor.authorPereira, Cidália Almeida
dc.date.accessioned2025-10-29T16:20:00Z
dc.date.available2025-10-29T16:20:00Z
dc.date.issued2019-09-30
dc.description.abstractBone mineral density (BMD) and microstructure depend on estrogens and diet. We assessed the impact of natural mineral-rich water ingestion on distal femur of fructose-fed estrogen-deficient female Sprague Dawley rats. Ovariectomized rats drank tap or mineral-rich waters, with or without 10%-fructose, for 10 weeks. A sham-operated group drinking tap water was included (n = 6/group). Cancellous and cortical bone compartments were analyzed by microcomputed tomography. Circulating bone metabolism markers were measured by enzyme immunoassay/enzyme-linked immunosorbent assay or multiplex bead assay. Ovariectomy significantly worsened cancellous but not cortical bone, significantly increased circulating degradation products from C-terminal telopeptides of type I collagen and receptor activator of nuclear factor-kappaB ligand (RANKL), and significantly decreased circulating osteoprotegerin and osteoprotegerin/RANKL ratio. In ovariectomized rats, in cancellous bone, significant water effect was observed for all microstructural properties, except for the degree of anisotropy, and BMD (neither a significant fructose effect nor a significant interaction between water and fructose ingestion effects were observed). In cortical bone, it was observed a significant (a) water effect for medullary volume and cortical endosteal perimeter; (b) fructose effect for cortical thickness, medullary volume, cross-sectional thickness and cortical endosteal and periosteal perimeters; and (c) interaction effect for mean eccentricity. In blood, significant fructose and interaction effects were found for osteoprotegerin (no significant water effect was seen). For the first time in ovariectomized rats, the positive modulation of cortical but not of cancellous bone by fructose ingestion and of both bone locations by natural mineral-rich water ingestion is describedpor
dc.description.sponsorshipThis work was supported by FEDER—Fundo Europeu de Desenvolvimento Regional (through NORTE 2020 Programa Operacional Regional do Norte—NORTE-01-0145-FEDER-000012), Unicer Bebidas, S.A., Portugal and to CP; SFRH/BD/71149/2010 to EP; SFRH/BD/79716/2011 to NS and UID/BIM/04293/2013 to Instituto de Investigação e Inovação em Saúde (Projeto Estratégico)). When considering the funding by Unicer Bebidas, S.A., it should be mentioned that the study here presented was developed, in its full extent, both in scientific terms and research equipment conditions, independently of the beverage company
dc.identifier.citationPereira, C., Guede, D., Durães, C., Brandão, I., Silva, N., Passos, E., Bernardes, M., Monteiro, R., & Martins, M. J. (2019). Differential Modulation of Cancellous and Cortical Distal Femur by Fructose and Natural Mineral-Rich Water Consumption in Ovariectomized Female Sprague Dawley Rats. Nutrients, 11(10), 2316. https://doi.org/10.3390/nu11102316
dc.identifier.doi10.3390/nu11102316
dc.identifier.issn2072-6643
dc.identifier.urihttp://hdl.handle.net/10400.8/14427
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationOBESITY AND METABOLIC SYNDROME : AMELIORATION OF ASSOCIATED WESTER DIET THROUGH SOME BEVERAGES AND NUTRIENTS
dc.relationEXERCISE AND STATINS. INVESTIGATING THE ROLE OF DAILY PHYSICAL ACTIVITY AND AEROBIC FITNESS ON STATINS TREATMENT-INDUCED MUSCLE DYSFUNCTION
dc.relation.hasversionhttps://www.mdpi.com/2072-6643/11/10/2316
dc.relation.ispartofNutrients
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectBone mineral density
dc.subjectCancellous bone
dc.subjectCortical bone
dc.subjectFructose
dc.subjectMineral water
dc.subjectBone microstructure
dc.subjectOvariectomy
dc.titleDifferential Modulation of Cancellous and Cortical Distal Femur by Fructose and Natural Mineral-Rich Water Consumption in Ovariectomized Female Sprague Dawley Ratseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleOBESITY AND METABOLIC SYNDROME : AMELIORATION OF ASSOCIATED WESTER DIET THROUGH SOME BEVERAGES AND NUTRIENTS
oaire.awardTitleEXERCISE AND STATINS. INVESTIGATING THE ROLE OF DAILY PHYSICAL ACTIVITY AND AEROBIC FITNESS ON STATINS TREATMENT-INDUCED MUSCLE DYSFUNCTION
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/FARH/SFRH%2FBDE%2F33798%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/FARH/SFRH%2FBD%2F71149%2F2010/PT
oaire.citation.issue10
oaire.citation.titleNutrients
oaire.citation.volume11
oaire.fundingStreamFARH
oaire.fundingStreamFARH
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNamePereira
person.givenNameCidália Almeida
person.identifier.ciencia-idAC15-8934-CC03
person.identifier.orcid0000-0001-9934-9648
person.identifier.ridGPP-6411-2022
person.identifier.scopus-author-id56016000600
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isAuthorOfPublicationa4dd40ab-92e7-42e2-8a47-99f2f3879b89
relation.isAuthorOfPublication.latestForDiscoverya4dd40ab-92e7-42e2-8a47-99f2f3879b89
relation.isProjectOfPublication9a54adb0-b5e2-4525-89ec-1f17f5e153bd
relation.isProjectOfPublication2d4656f9-726f-4792-a94a-32361446449e
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