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Exploring marine resources against neurological disorders: the neuroprotective and anti‑inflammatory potential of the brown seaweed Bifurcaria bifurcata

2022Journal article Restricted access
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dc.contributor.authorSilva, Joana
dc.contributor.authorAlves, Celso
dc.contributor.authorSusano, Patrícia
dc.contributor.authorMartins, Alice
dc.contributor.authorPinteus, Susete
dc.contributor.authorGaspar, Helena
dc.contributor.authorAlfonso, Amparo
dc.contributor.authorPedrosa, Rui
dc.date.accessioned2022-08-23T13:34:22Z
dc.date.available2022-08-23T13:34:22Z
dc.date.issued2022
dc.descriptionFunding :This work was supported by the Portuguese Foundation for Science and Technology (FCT) through the strategic project UID/04292/2020 granted to MARE—Marine and Environmental Sciences Centre and under the project LA/P/0069/2020 granted to the Associate Laboratory ARNET, also through UIDP/04046/2020 and UIDB/04046/2020 granted to BioISI—BioSystems and Integrative Sciences Institute, through POINT4PAC project (Oncologia de Precisão: Terapias e Tecnologias Inovadoras, SAICTPAC/0019/ 2015-LISBOA- 01–0145-FEDER-016405), through CROSS-ATLANTIC project (PTDC/BIA-OUT/29250/2017), co-fnanced by COMPETE (POCI01–0145-FEDER-029250) and through Molecules for Health project (PTDC/ BIA-BQM/28355/2017). This work was also funded by the the National NMR Network (PTNMR), partially supported by Infrastructure Project Nº 022161 (co-fnanced by FEDER through COMPETE 2020, POCI and PORL and FCT through PIDDAC).pt_PT
dc.description.abstractOxidative stress is strongly involved in the pathogenesis of neurodegenerative diseases, like Parkinson´s disease (PD). Particularly, an excess of reactive oxygen species (ROS) released by the cells promotes an oxidative stress condition, which is a main cause of tissue injury leading to nervous system dysfunction. In this work, the antioxidant, neuroprotective and antiinflammatory activities of different fractions from the brown seaweed Bifurcaria bifurcata are presented and related with their chemical profile. The antioxidant capacity was evaluated by the Folin-Ciocalteu method, 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, ferric reducing antioxidant power (FRAP) and oxygen radical absorbance capacity (ORAC) assays. Neuroprotective capacity was evaluated to prevent neurological cell death mediated by the neurotoxin 6-hydroxydopamine (6-OHDA) on SH-SY5Y cells, and their anti-inflammatory effects on RAW 264.7 macrophages. The ethyl acetate fractions (100 μg mL−1) exhibited significant antioxidant and neuroprotective activities in the in vitro models assayed. Furthermore, two of the most polar fractions obtained with methanol and water also evidenced a significant neuroprotective potential. Bifurcaria bifurcata fractions treatment decreased ROS production, mitochondrial dysfunction, and Caspase-3 activity. Regarding the anti-inflammatory potential, five fractions (100 μg mL−1) inhibited nitric oxide (NO) production and reduced the interleukin – 6 (IL-6) and tumor necrosis factor (TNF-α) levels. Mannitol, identified as the major component of the most bioactive fraction, protected SH-SY5Y cells against the 6-OHDA neurotoxicity mediating ROS generation mitigation, mitochondrial dysfunction, and DNA damage, together with the Caspase-3 activity inhibition. Results suggest that B. bifurcata is a relevant source of neuroprotective agents, with particular interest for preventive therapeutics.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSilva, J., Alves, C., Susano, P. et al. Exploring marine resources against neurological disorders– the neuroprotective and anti-inflammatory potential of the brown seaweed Bifurcaria bifurcata. J Appl Phycol (2022). https://doi.org/10.1007/s10811-022-02794-zpt_PT
dc.identifier.doi10.1007/s10811-022-02794-zpt_PT
dc.identifier.issn1573-5176
dc.identifier.issn0921-8971
dc.identifier.urihttp://hdl.handle.net/10400.8/7584
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relationPOCI-01-0145-FEDER-029250pt_PT
dc.relationBiosystems and Integrative Sciences Institute
dc.relationBiosystems and Integrative Sciences Institute
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s10811-022-02794-zpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAntioxidantspt_PT
dc.subjectMitochondrial dysfunctionpt_PT
dc.subjectNeuroinflammationpt_PT
dc.subjectParkinson's diseasept_PT
dc.subjectSH-SY5Y cellspt_PT
dc.subjectRAW 264.7 cellspt_PT
dc.subjectPhaeophyceaept_PT
dc.titleExploring marine resources against neurological disorders: the neuroprotective and anti‑inflammatory potential of the brown seaweed Bifurcaria bifurcatapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleBiosystems and Integrative Sciences Institute
oaire.awardTitleBiosystems and Integrative Sciences Institute
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04046%2F2020/PT
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oaire.awardURIinfo:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FBIA-OUT%2F29250%2F2017/PT
oaire.citation.titleJournal of Applied Phycologypt_PT
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person.familyNameSilva
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rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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