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BSA-PEG Hydrogel: A Novel Protein-Ligand Binding 3D Matrix

2022-08-25Journal article Open access
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dc.contributor.authorCoelho, Carlos D. F.
dc.contributor.authorJesus, João A.
dc.contributor.authorVaz, Daniela C.
dc.contributor.authorLagoa, Ricardo
dc.contributor.authorMoreno, Maria João
dc.date.accessioned2022-10-21T13:54:30Z
dc.date.available2022-10-21T13:54:30Z
dc.date.issued2022-08-25
dc.description.abstractHydrogel materials have good biomimetic properties and high potential for biomedical and bioanalytical applications. In this work, a hydrogel of serum albumin crosslinked with poly-(ethylene glycol) was prepared and characterized for its water content, protein structure and stability. The ability of the hydrogel to bind small molecule ligands with different hydrophobicity was evaluated using a homologous series of amphiphiles (NBD-Cn, n = 4, 6 and 8) and the calculated binding affinities were similar to that of free protein in solution. Overall, the results indicate this type of hydrogel system as a convenient tool for studying the binding of xenobiotics to tissue proteins.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCoelho, C.D.F.; Jesus, J.A.; Vaz, D.C.; Lagoa, R.; Moreno, M.J. BSA-PEG Hydrogel: A Novel Protein-Ligand Binding 3D Matrix. Med. Sci. Forum 2022, 11, 1. https://doi.org/10.3390/ BiTaP-12878pt_PT
dc.identifier.doihttps://doi.org/10.3390/BiTaP-12878pt_PT
dc.identifier.eissn2673-9992
dc.identifier.urihttp://hdl.handle.net/10400.8/7803
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationMultifunctional biomolecular systems for new methods of decontamination, protection and toxicological assessment
dc.relationCoimbra Chemistry Center
dc.relationCoimbra Chemistry Center
dc.relation.publisherversionhttps://www.mdpi.com/2673-9992/11/1/1pt_PT
dc.subjectLigand bindingpt_PT
dc.subjectSerum albuminpt_PT
dc.subjectHydrogelpt_PT
dc.subjectProtein structurept_PT
dc.titleBSA-PEG Hydrogel: A Novel Protein-Ligand Binding 3D Matrixpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMultifunctional biomolecular systems for new methods of decontamination, protection and toxicological assessment
oaire.awardTitleCoimbra Chemistry Center
oaire.awardTitleCoimbra Chemistry Center
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIA-MIB%2F31864%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00313%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F00313%2F2020/PT
oaire.citation.endPage4pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleMed. Sci. Forum - Fórum de Ciências Médicaspt_PT
oaire.citation.volume11pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
person.familyNameBarroso de Moura Cipreste Vaz
person.familyNameLagoa
person.givenNameDaniela
person.givenNameRicardo
person.identifier124357
person.identifier.ciencia-id801A-7761-328C
person.identifier.ciencia-id5C18-A29A-44AB
person.identifier.orcid0000-0001-7562-4676
person.identifier.orcid0000-0003-2375-6612
person.identifier.ridR-5243-2017
person.identifier.scopus-author-id6602838931
person.identifier.scopus-author-id23051352300
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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