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Evaluation of PVA biodegradable electric conductive membranes for nerve regeneration in axonotmesis injuries: the rat sciatic nerve animal model

2017-02-13Journal article Restricted access
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dc.contributor.authorRibeiro, Jorge
dc.contributor.authorCaseiro, Ana Rita
dc.contributor.authorPereira, Tiago
dc.contributor.authorArmada‐da‐Silva, Paulo Alexandre
dc.contributor.authorPires, Isabel
dc.contributor.authorPrada, Justina
dc.contributor.authorIrina, Amorim
dc.contributor.authorReis, Inês Leal
dc.contributor.authorAmado, Sandra
dc.contributor.authorSantos, José Domingos
dc.contributor.authorBompasso, Simone
dc.contributor.authorRaimondo, Stefania
dc.contributor.authorVarejão, Artur Severo Proença
dc.contributor.authorGeuna, Stefano
dc.contributor.authorLuís, Ana Lúcia
dc.contributor.authorMaurício, Ana Colette
dc.date.accessioned2025-06-25T09:55:47Z
dc.date.available2025-06-25T09:55:47Z
dc.date.issued2017-02-13
dc.description.abstractThe therapeutic effect of three polyvinyl alcohol (PVA) membranes loaded with electrically conductive materials - carbon nanotubes (PVA-CNTs) and polypyrrole (PVA-PPy) - were tested in vivo for neuro-muscular regeneration after an axonotmesis injury in the rat sciatic nerve. The membranes electrical conductivity measured was 1.5 ± 0.5 × 10-6 S/m, 579 ± 0.6 × 10-6 S/m, and 1837.5 ± 0.7 × 10-6 S/m, respectively. At week-12, a residual motor and nociceptive deficit were present in all treated groups, but at week-12, a better recovery to normal gait pattern of the PVA-CNTs and PVA-PPy treated groups was observed. Morphometrical analysis demonstrated that PVA-CNTs group presented higher myelin thickness and lower g-ratio. The tibialis anterior muscle, in the PVA-PPy and PVA-CNTs groups showed a 9% and 19% increase of average fiber size area and a 5% and 10% increase of the "minimal Feret's diameter," respectively. No inflammation, degeneration, fibrosis or necrosis were detected in lung, liver, kidneys, spleen, and regional lymph nodes and absence of carbon deposits was confirmed with Von Kossa and Masson-Fontana stains. In conclusion, the membranes of PVA-CNTs and PVA-PPy are biocompatible and have electrical conductivity. The higher electrical conductivity measured in PVA-CNTs membrane might be responsible for the positive results on maturation of myelinated fibers. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 1267-1280, 2017eng
dc.identifier.citationRibeiro J, Caseiro AR, Pereira T, Armada-da-Silva PA, Pires I, Prada J, Amorim I, Leal Reis I, Amado S, Santos JD, Bompasso S, Raimondo S, Varejão AS, Geuna S, Luís AL, Maurício AC. Evaluation of PVA biodegradable electric conductive membranes for nerve regeneration in axonotmesis injuries: the rat sciatic nerve animal model. J Biomed Mater Res A. 2017 May;105(5):1267-1280. doi: 10.1002/jbm.a.35998. Epub 2017 Feb 13. PMID: 28078802
dc.identifier.doi10.1002/jbm.a.35998
dc.identifier.issn1549-3296
dc.identifier.issn1552-4965
dc.identifier.urihttp://hdl.handle.net/10400.8/13413
dc.language.isoeng
dc.peerreviewedyes
dc.publisherWiley
dc.relation.hasversionhttps://pubmed.ncbi.nlm.nih.gov/28078802/
dc.relation.ispartofJournal of Biomedical Materials Research Part A
dc.rights.uriN/A
dc.subjectaxonotmesis
dc.subjectcarbon nanotubes
dc.subjectfunctional analysis
dc.subjectmorphometric analysis
dc.subjectnerve regeneration
dc.subjectnerve-guides
dc.subjectneurogenic atrophy
dc.subjectpolypyrrole
dc.subjectpolyvinyl alcohol
dc.titleEvaluation of PVA biodegradable electric conductive membranes for nerve regeneration in axonotmesis injuries: the rat sciatic nerve animal modeleng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1280
oaire.citation.issue5
oaire.citation.startPage1267
oaire.citation.titleJournal of Biomedical Materials Research Part A
oaire.citation.volume105
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameAmado
person.givenNameSandra
person.identifier804352
person.identifier.ciencia-idD617-149A-8102
person.identifier.orcid0000-0001-8356-4810
person.identifier.ridO-6988-2016
person.identifier.scopus-author-id16038616600
relation.isAuthorOfPublicationaea9bcf4-4f9f-4b2d-9d73-fec5ad76dcc4
relation.isAuthorOfPublication.latestForDiscoveryaea9bcf4-4f9f-4b2d-9d73-fec5ad76dcc4

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