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Influence of the Rheological Behaviour in Electrospun PCL Nanofibres Production for Tissue Engineering Applications

2013Comunicação em conferência Acesso aberto
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datacite.subject.fosEngenharia e Tecnologia::Engenharia Química
datacite.subject.fosEngenharia e Tecnologia::Biotecnologia Industrial
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
datacite.subject.sdg12:Produção e Consumo Sustentáveis
dc.contributor.authorDias, Juliana R.
dc.contributor.authorAntunes, Filipe E.
dc.contributor.authorBártolo, Paulo J.
dc.date.accessioned2026-03-24T16:40:06Z
dc.date.available2026-03-24T16:40:06Z
dc.date.issued2013
dc.description.abstractA strategy to obtain functional tissues engineering with desired biomechanical properties was used to develop scaffolds with morphologies mimicking the native environment to guide tissue regeneration. Nonwoven scaffolds, with fibre dimensions at a nanometre scale, can mimic the physical structure of natural extracellular matrices (ECM). Though its clinical application is yet limited, nano/micro fibrous scaffolds produced by electrospinning gains more and more interest in different Tissue Engineering fields. The electrospinning technique is controlled by several parameters, such as polymer solution and processing ambient, being one of the most important parameters the solution viscosity, which allows defining the minimum viscosity needed to obtain fibres. This research work investigates the rheological behaviour of PCL solutions to produce nanoscale fibre meshes for cartilage application. Poly (ε-caprolactone) (PCL) solutions were prepared using glacial acetic acid (AA) and glacial acetic acid with triethylamine (AA/TEA) at different concentrations. It was necessary to double the value of the critical concentration (c*), that is 10 wt% for PCL/AA and 9,6wt% for PCL/AA/TEA, to prepare suitable fibres. Results also show that a more homogenous mesh can be produced by adding TEA.eng
dc.description.sponsorshipJuliana Dias thanks the Centre for Rapid Development and Sustainable Product for the research grant awarded for the work. The authors also thank the Centre for Advanced Microscopy, University of Reading and in particular Dr. Chris Stain and Dr. Geoffrey Mitchell for the SEM micrographs of the electrospun meshes, to the Chemistry Department, University of Coimbra for the rheological measurements and the support by Foundation for Science and Technology through the strategic project PESOE/EME/UI4044/2011.
dc.identifier.citationJuliana, R. D., Filipe, E. A., & Paulo, J. B. (2013). Influence of the rheological behaviour in electrospun PCL nanofi bres production for tissue engineering applications. Chemical Engineering Transactions. AIDIC, 32, 1015-1020.
dc.identifier.doi10.3303/CET1332170
dc.identifier.issn2283-9216
dc.identifier.urihttp://hdl.handle.net/10400.8/15975
dc.language.isoeng
dc.peerreviewedyes
dc.publisherItalian Association of Chemical Engineering - AIDIC
dc.relationStrategic Project - UI 4044 - 2011-2012
dc.rights.uriN/A
dc.titleInfluence of the Rheological Behaviour in Electrospun PCL Nanofibres Production for Tissue Engineering Applicationseng
dc.typeconference paper
dspace.entity.typePublication
oaire.awardNumberPEst-OE/EME/UI4044/2011
oaire.awardTitleStrategic Project - UI 4044 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FEME%2FUI4044%2F2011/PT
oaire.citation.conferenceDate2013
oaire.citation.endPage1020
oaire.citation.startPage1015
oaire.citation.titleChemical Engineering Transactions
oaire.citation.volume32
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameDias
person.familyNameBartolo
person.givenNameJuliana
person.givenNamePaulo
person.identifier633669
person.identifier203086
person.identifier.ciencia-id0612-D971-F00D
person.identifier.ciencia-id5810-9BF9-4522
person.identifier.orcid0000-0002-7079-1069
person.identifier.orcid0000-0003-3683-726X
person.identifier.ridA-6086-2014
person.identifier.ridF-2421-2013
person.identifier.scopus-author-id55749822200
person.identifier.scopus-author-id6603353041
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isAuthorOfPublication9e70a657-1b71-4366-ab59-b9f988a19d5a
relation.isAuthorOfPublicationab44d1ae-46d0-45c2-b19f-200024b5a990
relation.isAuthorOfPublication.latestForDiscovery9e70a657-1b71-4366-ab59-b9f988a19d5a
relation.isProjectOfPublication44bd1c93-9ee1-4685-a408-c2baa61ffbcd
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