Repository logo
 
Publication

In situ enabling approaches for tissue regeneration: Current challenges and new developments

2020Journal article Open access
Simple item page
dc.contributor.authorDias, Juliana R.
dc.contributor.authorRibeiro, Nilza
dc.contributor.authorBaptista-Silva, Sara
dc.date.accessioned2023-04-17T09:44:27Z
dc.date.available2023-04-17T09:44:27Z
dc.date.issued2020
dc.descriptionThis work was supported by National Funds from the FCT, Fundação para a Ciência e a Tecnologia, through the projects UID/Multi/50016/2019, UID/Multi/04044/2019, and POCI-01-0145-FEDER-31146, a post-doctoral fellowship to SB-S (SFRH/BPD/116024/2016), the European Union through PT2020 and Centro2020 (CENTRO-01-0145-FEDER-000014 and POCI-01-0247-FEDER-024533), the Fundo Europeu de Desenvolvimento Regional (FEDER) through the project NORTE-01-0145-FEDER-000012 (Biotherapies – Structured Programme on Bioengineering Therapies for Infectious Diseases and Tissue Regeneration) funded by the NORTE2020 program, and the Interreg V-A POCTEP Program through FEDER funds from the European Union (0245_IBEROS_1_E).pt_PT
dc.description.abstractIn situ tissue regeneration can be defined as the implantation of tissue-specific biomaterials (by itself or in combination with cells and/or biomolecules) at the tissue defect, taking advantage of the surrounding microenvironment as a natural bioreactor. Up to now, the structures used were based on particles or gels. However, with the technological progress, the materials’ manipulation and processing has become possible, mimicking the damaged tissue directly at the defect site. This paper presents a comprehensive review of current and advanced in situ strategies for tissue regeneration. Recent advances to put in practice the in situ regeneration concept have been mainly focused on bioinks and bioprinting techniques rather than the combination of different technologies to make the real in situ regeneration. The limitation of conventional approaches (e.g., stem cell recruitment) and their poor ability to mimic native tissue are discussed. Moreover, the way of advanced strategies such as 3D/4D bioprinting and hybrid approaches may contribute to overcome the limitations of conventional strategies are highlighted. Finally, the future trends and main research challenges of in situ enabling approaches are discussed considering in vitro and in vivo evidence.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationDias JR, Ribeiro N, Baptista-Silva S, Costa-Pinto AR, Alves N and Oliveira AL (2020) In situ Enabling Approaches for Tissue Regeneration: Current Challenges and New Developments. Front. Bioeng. Biotechnol. 8:85. doi: 10.3389/fbioe.2020.00085pt_PT
dc.identifier.doi10.3389/fbioe.2020.00085pt_PT
dc.identifier.issn2296-4185
dc.identifier.urihttp://hdl.handle.net/10400.8/8388
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontierspt_PT
dc.relationCentre for Biotechnology and Fine Chemistry
dc.relationCentre for Rapid and Sustainable Product Development
dc.relationNew bioactive, in situ forming sericin-based hybrid hydrogels for wound healing of diabetic ulcers
dc.relation.publisherversionhttps://www.frontiersin.org/articles/10.3389/fbioe.2020.00085/fullpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectIn situ approachespt_PT
dc.subjectTissue regenerationpt_PT
dc.subjectBioprintingpt_PT
dc.subjectIn situ biomaterialspt_PT
dc.subjectComputer/non-computer assisted approachespt_PT
dc.titleIn situ enabling approaches for tissue regeneration: Current challenges and new developmentspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre for Biotechnology and Fine Chemistry
oaire.awardTitleCentre for Rapid and Sustainable Product Development
oaire.awardTitleNew bioactive, in situ forming sericin-based hybrid hydrogels for wound healing of diabetic ulcers
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F50016%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F04044%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBPD%2F116024%2F2016/PT
oaire.citation.titleFrontiers in Bioengineering and Biotechnologypt_PT
oaire.citation.volume8pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamPOR_NORTE
person.familyNameDias
person.givenNameJuliana
person.identifier633669
person.identifier.ciencia-id0612-D971-F00D
person.identifier.orcid0000-0002-7079-1069
person.identifier.ridA-6086-2014
person.identifier.scopus-author-id55749822200
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication9e70a657-1b71-4366-ab59-b9f988a19d5a
relation.isAuthorOfPublication.latestForDiscovery9e70a657-1b71-4366-ab59-b9f988a19d5a
relation.isProjectOfPublication837d31a5-6cd5-4a27-a8dc-822e485eb2ac
relation.isProjectOfPublicationaba3abaa-39ca-424c-a7d7-4d06649c5236
relation.isProjectOfPublication6cf13601-73b5-489c-904b-db4f0209e507
relation.isProjectOfPublication.latestForDiscoveryaba3abaa-39ca-424c-a7d7-4d06649c5236

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Dias et al_2020_In situ enabling.pdf
Size:
12.78 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.32 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

CDRsp - Artigos em revistas internacionais
ESTG - Artigos em revistas internacionais