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Publication
Kidney Injury in type 2 diabetic: the role of berberine treatment
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Authors
Advisor(s)
Abstract(s)
rType 2 diabetes mellitus is a multifactorial disease. Prolonged hyperglycemia is
one of the major determinants of long-term complications of diabetes. Diabetic
nephropathy (DN) refers to a set of structural and functional changes which arise
in response to chronic glycemic attack. Because diabetes is a progressive disease,
pharmacotherapies with complementary mechanisms of action will be necessary
to achieve glycemic goals.
Berberine is a natural alkaloid isolated from the Coptis Chinensis. Although
routinely prescribe in Asian countries, an interest in its beneficial effects in
metabolic diseases has been growing in the Western world over the last decade.
The aim of our work was to analyze the effects of BBR in T2DM, specifically in
several markers of diabetic nephropathy. To realize our work we analyzed the
metabolic profile and several parameters (energy homeostasis, inflammation and
fibrosis) in cortex kidney tissue of 12 month old rats.
To testing the effects of this natural compound in diabetic renal disease, we will
go studding the profile metabolic of these animals. In renal tissue we will go
evaluated the activity of two enzymes activated protein kinase (AMPK) and
Sirtuin (Sirt)-1. Besides that, it is essential to study the role of several parameters
in the evolution of renal disease like, Transforming growth factor (TGF)-β and
pro-inflammatory cytokines
In conclusion, berberine is a valuable candidate for diabetic renal disease
therapy?
Description
Keywords
Type 2 diabetes Renal disease Berberine
Citation
Louro, T. (2015). Kidney Injury in Type 2 Diabetic: The Role of Berberine Treatment. Res Net Health 1, ennis6.
Publisher
Instituto Politécnico de Leiria