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A comparison of 3D poly(ε-caprolactone) tissue engineering scaffolds produced with conventional and additive manufacturing techniques by means of quantitative analysis of SR μ-CT images

2013-07-01Artigo científico Acesso restrito
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datacite.subject.fosEngenharia e Tecnologia::Engenharia dos Materiais
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
datacite.subject.sdg12:Produção e Consumo Sustentáveis
dc.contributor.authorBrun, F
dc.contributor.authorIntranuovo, F
dc.contributor.authorMohammadi, S
dc.contributor.authorDomingos, M.
dc.contributor.authorFavia, P
dc.contributor.authorTromba, G
dc.date.accessioned2026-03-11T17:45:00Z
dc.date.available2026-03-11T17:45:00Z
dc.date.issued2013-07-01
dc.description.abstractThe technique used to produce a 3D tissue engineering (TE) scaffold is of fundamental importance in order to guarantee its proper morphological characteristics. An accurate assessment of the resulting structural properties is therefore crucial in order to evaluate the effectiveness of the produced scaffold. Synchrotron radiation (SR) computed microtomography (μ-CT) combined with further image analysis seems to be one of the most effective techniques to this aim. However, a quantitative assessment of the morphological parameters directly from the reconstructed images is a non trivial task. This study considers two different poly(ε-caprolactone) (PCL) scaffolds fabricated with a conventional technique (Solvent Casting Particulate Leaching, SCPL) and an additive manufacturing (AM) technique (BioCell Printing), respectively. With the first technique it is possible to produce scaffolds with random, non-regular, rounded pore geometry. The AM technique instead is able to produce scaffolds with square-shaped interconnected pores of regular dimension. Therefore, the final morphology of the AM scaffolds can be predicted and the resulting model can be used for the validation of the applied imaging and image analysis protocols. It is here reported a SR μ-CT image analysis approach that is able to effectively and accurately reveal the differences in the pore- and throat-size distributions as well as connectivity of both AM and SCPL scaffolds.eng
dc.description.sponsorshipDr. Roberto Gristina (IMIP-CNR Bari, Italy) and Dr. Giacomo Ceccone (EC-JRC-IHCP, Ispra, VA—Italy) are gratefully acknowledged for their help during data acquisition.
dc.identifier.citationBrun, F., Intranuovo, F., Mohammadi, S., Domingos, M., Favia, P., & Tromba, G. (2013). A comparison of 3D poly (ε-caprolactone) tissue engineering scaffolds produced with conventional and additive manufacturing techniques by means of quantitative analysis of SR μ-CT images. Journal of Instrumentation, 8(07), C07001-C07001.
dc.identifier.doi10.1088/1748-0221/8/07/c07001
dc.identifier.issn1748-0221
dc.identifier.urihttp://hdl.handle.net/10400.8/15847
dc.language.isoeng
dc.peerreviewedyes
dc.publisherIOP Publishing
dc.relation.hasversionhttps://iopscience.iop.org/article/10.1088/1748-0221/8/07/C07001
dc.relation.ispartofJournal of Instrumentation
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAnalysis and statistical methods
dc.subjectImage reconstruction in medical imaging
dc.titleA comparison of 3D poly(ε-caprolactone) tissue engineering scaffolds produced with conventional and additive manufacturing techniques by means of quantitative analysis of SR μ-CT imageseng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPageC07001
oaire.citation.issue07
oaire.citation.startPageC07001
oaire.citation.titleJournal of Instrumentation
oaire.citation.volume8
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameDomingos
person.givenNameMarco
person.identifier.ciencia-idB512-2D06-5897
person.identifier.orcid0000-0002-6693-790X
relation.isAuthorOfPublication1fb3bd4b-f499-4db6-93c1-3a671f116d07
relation.isAuthorOfPublication.latestForDiscovery1fb3bd4b-f499-4db6-93c1-3a671f116d07

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