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Lichen planus and its therapeutic management: a retrospective study

2021-03-25Journal article Open access
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datacite.subject.fosCiências Médicas::Medicina Clínica
datacite.subject.fosCiências Médicas::Outras Ciências Médicas
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorRebelo, Mariana Rodrigues
dc.contributor.authorPereira, Cristina Palmela
dc.contributor.authorSantos, Rui Sousa
dc.contributor.authorSoares-de-Almeida, Luís
dc.contributor.authorFilipe, Paulo
dc.date.accessioned2025-10-16T10:04:01Z
dc.date.available2025-10-16T10:04:01Z
dc.date.issued2021-03-25
dc.description.abstractObjectives: To study the epidemiological distribution of the disease lichen planus and its therapeutic management. Methods: A total of 174 patients with a lichen planus diagnosis between 2008 and 2017 at a Portuguese public hospital were included in this retrospective study. The following data were collected from clinical records: gender, age, topographic distribution of lesions, prescribed therapy (active substance, route, and scheme of administration), mean duration of illness, and episodes of cure and relapse. Statistical analysis was performed using IBM® SPSS® Statistics software, version 25. Results: In this population, lichen planus affected both genders with the same probability (p=0.820), and was more prevalent in the 4th-5th decades of age. The lesions appeared in the skin (75.9% of the patients), mucous membranes (5.2%), or both (19.0%). The most prescribed drugs were corticosteroids, followed by antihistamines and immunosuppressants. Topical corticosteroids were the most common ones, namely clobetasol propionate (37.4%). Within the systemic corticosteroids, prednisolone was the most prescribed drug (12.3%). The average duration of lesions and symptoms was approximately 6.5 months. For the relapsing population (12%), the mean period of symptoms’ remission was 513 days. Conclusions: The epidemiological parameters of lichen planus in these Portuguese patients bear similarities with other described populations. No evidence-based therapeutic has proven to be effective for lichen planus treatment, but topical corticosteroids continue to be the first-line therapy for this pathology.eng
dc.description.abstractObjetivos: Caracterizar epidemiologicamente a patologia Líquen Plano e sua abordagem terapêutica. Métodos: Neste estudo retrospetivo, foram incluídos 174 pacientes, de um hospital público português, com diagnóstico de Líquen Plano entre os anos 2008 e 2017. Os registos médicos permitiram a recolha de informação relativa a género, idade, distribuição topográfica das lesões de Líquen Plano, terapêutica prescrita (princípio ativo, via de administração e esquema terapêutico), duração média da doença, episódios de cura e recidiva. A análise estatística foi realizada com recurso ao software IBM® SPSS® Statistics, versão 25. Resultados: Nesta população, a doença afetou ambos os géneros com a mesma probabilidade (p=0,820), no entanto, com maior prevalência na 4.ª e 5.ª décadas de idade. As lesões de Líquen Plano manifestaram-se na pele (em 75,9% dos doentes), nas mucosas (5,2%), ou em ambos (19,0%). Os fármacos mais prescritos foram os corticosteróides, seguidos dos anti-histamínicos e dos imunossupressores. Os corticosteróides tópicos foram os mais comumente administrados, nomeadamente o Propionato de Clobetasol (37,4%). Dentro dos corticosteróides sistémicos, a Prednisolona foi o fármaco mais utilizado (12,3%). A duração média das lesões e sintomas foi de aproximadamente 6,5 meses. Para a população que recidivou (12%), o período médio de remissão dos sintomas foi de 513 dias. Conclusões: Os parâmetros epidemiológicos desta amostra de pacientes portugueses com Líquen Plano partilham semelhanças com outras populações descritas. Nenhuma terapêutica baseada em evidência provou ser eficaz para o tratamento do Líquen Plano. No entanto, os corticosteróides tópicos continuam a apresentar-se como a solução terapêutica de primeira linha para esta patologia.por
dc.description.sponsorshipResearch Centre of Statistical and Applications of University of Lisbon (CEAUL) under the project UIDB/00006/2020, Fundação Nacional para a Ciência e a Tecnologia (FCT), Portugal.
dc.identifier.citationRebelo, M. R., Pereira, C. P., Santos, R. S., Soares-de-Almeida, L., & Filipe, P. (2021). Lichen planus and its therapeutic management: a retrospective study. Revista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilofacial, 62(1), 29-34. DOI: https://doi.org/10.24873/j.rpemd.2021.03.825.
dc.identifier.doi10.24873/j.rpemd.2021.03.825
dc.identifier.eissn1647-6700
dc.identifier.issn1646-2890
dc.identifier.urihttp://hdl.handle.net/10400.8/14280
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSociedade Portuguesa de Estomatologia e Medicina Dentária (SPEMD)
dc.relationCentre of Statistics and its Applications
dc.relation.hasversionhttps://revista.spemd.pt/article/1659
dc.relation.ispartofRevista Portuguesa de Estomatologia, Medicina Dentária e Cirurgia Maxilofacial
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectCorticosteroids
dc.subjectDermatology
dc.subjectEpidemiology
dc.subjectLichen planus
dc.subjectTherapeutics
dc.subjectCorticoesteróides
dc.subjectDermatologia
dc.subjectEpidemiologia
dc.subjectLíquen plano
dc.subjectTerapêutica
dc.titleLichen planus and its therapeutic management: a retrospective studyeng
dc.title.alternativeLíquen Plano e abordagem terapêutica: um estudo retrospetivopor
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre of Statistics and its Applications
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00006%2F2020/PT
oaire.citation.endPage34
oaire.citation.issue1
oaire.citation.startPage29
oaire.citation.titleRevista Portuguesa de Estomatologia Medicina Dentária e Cirurgia Maxilofacial
oaire.citation.volume62
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameSantos
person.givenNameRui
person.identifier1051057
person.identifier.ciencia-id7610-8B27-8044
person.identifier.orcid0000-0002-7371-363X
person.identifier.ridC-1873-2015
person.identifier.scopus-author-id56979441000
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isAuthorOfPublicationfba82887-7d94-41f6-a4aa-06b7de054567
relation.isAuthorOfPublication.latestForDiscoveryfba82887-7d94-41f6-a4aa-06b7de054567
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Objectives: To study the epidemiological distribution of the disease lichen planus and its therapeutic management. Methods: A total of 174 patients with a lichen planus diagnosis between 2008 and 2017 at a Portuguese public hospital were included in this retrospective study. The following data were collected from clinical records: gender, age, topographic distribution of lesions, prescribed therapy (active substance, route, and scheme of administration), mean duration of illness, and episodes of cure and relapse. Statistical analysis was performed using IBM® SPSS® Statistics software, version 25. Results: In this population, lichen planus affected both genders with the same probability (p=0.820), and was more prevalent in the 4th-5th decades of age. The lesions appeared in the skin (75.9% of the patients), mucous membranes (5.2%), or both (19.0%). The most prescribed drugs were corticosteroids, followed by antihistamines and immunosuppressants. Topical corticosteroids were the most common ones, namely clobetasol propionate (37.4%). Within the systemic corticosteroids, prednisolone was the most prescribed drug (12.3%). The average duration of lesions and symptoms was approximately 6.5 months. For the relapsing population (12%), the mean period of symptoms’ remission was 513 days. Conclusions: The epidemiological parameters of lichen planus in these Portuguese patients bear similarities with other described populations. No evidence-based therapeutic has proven to be effective for lichen planus treatment, but topical corticosteroids continue to be the first-line therapy for this pathology.
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