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Publication
Multi-LASER acquisition system for microbial activity analysis using LASER Speckle technique
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Authors
Abstract(s)
Nas últimas décadas houve um aumento da taxa de mortes devido a infeções, que é agravado pelas
bactérias resistentes aos antibióticos em constante crescimento [1]. Atualmente, as metodologias de
teste requerem longos períodos de espera de 24 horas (ou mais) para realizar testes de suscetibilidade
antibiótica de amostras bacterianas retiradas de pacientes. Este longo período de espera pode levar
à propagação da infeção, resultando em complicações de saúde adicionais ou, em última instância, na
morte. O sistema proposto aborda esta lacuna nas abordagens de teste, utilizando um dispositivo de
imagem (câmara) em conjunto com iluminação laser, para encurtar o período de tempo entre a recolha
da amostra e os resultados de suscetibilidade antibiótica. Os testes realizados em ambiente laboratorial
mostraram que a deteção da suscetibilidade pode ser alcançada em apenas três horas, com a perspetiva
de reduzir este período de teste através da utilização de algoritmos de pós-processamento de última
geração. Ao empregar as melhorias propostas, este tipo de sistema pode tornar-se mainstream em todos
os hospitais, fornecendo um método rápido e fiável para selecionar os antibióticos corretos para cada
paciente, resultando provavelmente numa diminuição das mortes relacionadas com infeções.
In the last decades there has been an increase in the rate of deaths due to infections, which is aggravated by the ever increasing antibiotic-resistant bacteria [1]. Currently, testing methodologies require long waiting periods of 24 hours (or more) to perform antibiotic susceptibility tests of bacterial samples taken from patients. This long waiting period can lead to the spread of the infection, resulting in further health complications or, ultimately, death. The proposed system tackles this gap in testing approaches, by using an imaging device (camera) in conjunction with laser lighting, to shorten the time span between sample retrieval and antibiotic susceptibility results. Testing performed in laboratory environment showed that the detection of susceptibility could be achieved as early as three hours, with the prospect of reducing this testing period by using state of the art post processing algorithms. By employing the proposed improvements, this type of system could become mainstream in every hospital, providing a quick and reliable method to select the correct antibiotics for each patient, likely resulting in a decrease in infection related deaths.
In the last decades there has been an increase in the rate of deaths due to infections, which is aggravated by the ever increasing antibiotic-resistant bacteria [1]. Currently, testing methodologies require long waiting periods of 24 hours (or more) to perform antibiotic susceptibility tests of bacterial samples taken from patients. This long waiting period can lead to the spread of the infection, resulting in further health complications or, ultimately, death. The proposed system tackles this gap in testing approaches, by using an imaging device (camera) in conjunction with laser lighting, to shorten the time span between sample retrieval and antibiotic susceptibility results. Testing performed in laboratory environment showed that the detection of susceptibility could be achieved as early as three hours, with the prospect of reducing this testing period by using state of the art post processing algorithms. By employing the proposed improvements, this type of system could become mainstream in every hospital, providing a quick and reliable method to select the correct antibiotics for each patient, likely resulting in a decrease in infection related deaths.
Description
Keywords
Saúde Testes de suscetibilidade Testes antimicrobianos Resistência antimicrobiana Antibiótico Infeções bacterianas