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Multi-material cellular structured orthopedic implants design: In vitro and bio-tribological performance

2022Journal article Open access
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dc.contributor.authorCosta, M.M.
dc.contributor.authorLima, R.
dc.contributor.authorAlves, N.
dc.contributor.authorSilva, N.A.
dc.contributor.authorGasik, M.
dc.contributor.authorBartolomeu, F.
dc.contributor.authorMiranda, G.
dc.date.accessioned2023-04-12T12:52:51Z
dc.date.available2023-04-12T12:52:51Z
dc.date.issued2022
dc.descriptionCEECIND/04794/2007, Add2MechBio, NORTE-01-0145-FEDER-029968, PPBI–POCI-01-0145-FEDER-022122, LA/P/0006/2020,pt_PT
dc.description.abstractIn this study, Selective Laser Melting (SLM) was used to produce mono-material Ti64Al4V- and NiTi-cubic cellular structures with an open-cell size and wall thickness of 500 μm and 100 μm, respectively. Bioactive beta-tricalcium phosphate (βTCP) and polymer poly-ether-ether ketone (PEEK) were used to fill the produced structures open-cells, thus creating multi-material components. These structures were characterized in vitro in terms of cell viability, adhesion, differentiation and mineralization. Also, bio-tribological experiments were performed against bovine plate to mimic the moment of implant insertion. Results revealed that metabolic activity and mineralization were improved on SLM mono-material groups, when compared to the control group. All cell metrics were improved with the addition of PEEK, conversely to βTCP where no significant differences were found. These results suggest that the proposed solutions can be used to improve implants performance.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationM.M. Costa, R. Lima, N. Alves, N.A. Silva, M. Gasik, F.S. Silva, F. Bartolomeu, G. Miranda, Multi-material cellular structured orthopedic implants design: In vitro and bio-tribological performance, Journal of the Mechanical Behavior of Biomedical Materials, Volume 131, 2022, 105246, ISSN 1751-6161, https://doi.org/10.1016/j.jmbbm.2022.105246.pt_PT
dc.identifier.doi10.1016/j.jmbbm.2022.105246pt_PT
dc.identifier.issn1751-6161
dc.identifier.urihttp://hdl.handle.net/10400.8/8361
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationalterado para: “Multi-Functional Multi-Material Structures for Orthopedic Implants using Laser-Assisted Strategies” Smart Bioactive Structures for Implants for Life
dc.relationCICECO-Aveiro Institute of Materials
dc.relationCICECO-Aveiro Institute of Materials
dc.relationMicroelectromechanical Systems Research Unit
dc.relationMicroelectromechanical Systems Research Unit
dc.relationLA - ICVS/3B's - Associate Laboratory
dc.relationLA - ICVS/3B's - Associate Laboratory
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S175161612200162Xpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectMulti-material structurespt_PT
dc.subjectNiTi-Basedpt_PT
dc.subjectTi6Al4V-basedpt_PT
dc.subjectIn vitropt_PT
dc.subjectBio-tribological experimentspt_PT
dc.titleMulti-material cellular structured orthopedic implants design: In vitro and bio-tribological performancept_PT
dc.typejournal article
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oaire.awardTitleCICECO-Aveiro Institute of Materials
oaire.awardTitleCICECO-Aveiro Institute of Materials
oaire.awardTitleMicroelectromechanical Systems Research Unit
oaire.awardTitleMicroelectromechanical Systems Research Unit
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oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F140191%2F2018/PT
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oaire.citation.titleJournal of the Mechanical Behavior of Biomedical Materialspt_PT
oaire.citation.volume131pt_PT
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