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Seaweeds polyphenolic bioactive extracts as a potential source for incorporating in multi-fiber orientation electrospun meshes for chronic wound healing applications: Diabetic ulcers
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Advanced face mask filters based on PCL electrospun meshes dopped with antimicrobial MgO and CuO nanoparticles
Publication . Ferreira, Carolina A. M.; Guerreiro, Sara F.C.; Valente, Joana F. A.; Patrício, Tatiana M.F.; Alves, Nuno; Mateus, Artur; Dias, Juliana R.
The pandemic situation caused by coronavirus clearly demonstrated the need for alternatives able to protect the respiratory tract and inactivate the infectious agents. Based on this, antibacterial face-mask filters of polycaprolactone (PCL) dopped with magnesium oxide (MgO) and copper oxide (CuO) nanoparticles (NPs) were produced using an electrospinning technique. A morphological analysis of electrospun meshes evaluated the success of nanoparticles’ incorporation as well as the average fibers’ diameters (481 +- 272 nm). The performance of electrospun nanofibers was also assessed in terms of tensile strength (0.88 +- 0.25 MPa), water vapor permeability (11,178.66 +- 35.78 g.m-2.day-1), stability under wet conditions and antibacterial activity according to the standard guidelines. The filters showed structural stability up to 2 h of washing and improved antibacterial activity against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) for optimized concentrations of MgO and CuO NPs. Overall, electrospun meshes with antibacterial activity were successfully developed for advanced filtering applications.
Current Strategies to Produce 3D Electrospun-Based Wound Dressings for Skin Regeneration
Publication . Ferreira, Carolina A. M.; Lemos, Marco F. L.; Maurício, Ana Colette; Dias, Juliana R.
Tissue engineering-based wound dressings are a promising treatment approach that mimics the native skin microenvironment to promote effective healing and tissue regeneration. In fact, those advanced wound dressings can be made by electrospinning which has revolutionized the field of wound healing by developing biostructures that closely mimic the skin’s extracellular matrix (ECM). To date, most electrospinning research has focused on composition and materials rather than exploring advanced deposition strategies. Conventional electrospinning using random, aligned fibers, co-electrospinning, core-shell approaches, or redesigned collectors has achieved significant results in wound healing, which are discussed in this article. However, these approaches lack the development of realistic 3D structures. To achieve that, advancing approaches through the combination of electrospinning with different techniques such as gas foaming, short nanofiber assembly, or 3D printing significantly enhance skin regeneration of deep wounds (full-thickness and chronic wounds) compared to 2D structures. This review highlights the latest developments, design principles, and recent breakthroughs in electrospinning structures for skin regeneration and provides a fresh perspective for upcoming research in the field of 3D electrospun-based structures.
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Fundação para a Ciência e a Tecnologia
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POR_CENTRO
Número da atribuição
2021.04541.BD