Implantable electrospun nanofibers containing gold nanoparticles for local enhancement of radiotherapy in gastric tumors

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Advanced face mask filters based on PCL electrospun meshes dopped with antimicrobial MgO and CuO nanoparticles

Publication . Ferreira, Carolina A. M.; Guerreiro, Sara F.C.; Valente, Joana F. A.; Patrício, Tatiana M.F.; Alves, Nuno; Mateus, Artur; Dias, Juliana R.

The pandemic situation caused by coronavirus clearly demonstrated the need for alternatives able to protect the respiratory tract and inactivate the infectious agents. Based on this, antibacterial face-mask filters of polycaprolactone (PCL) dopped with magnesium oxide (MgO) and copper oxide (CuO) nanoparticles (NPs) were produced using an electrospinning technique. A morphological analysis of electrospun meshes evaluated the success of nanoparticles’ incorporation as well as the average fibers’ diameters (481 +- 272 nm). The performance of electrospun nanofibers was also assessed in terms of tensile strength (0.88 +- 0.25 MPa), water vapor permeability (11,178.66 +- 35.78 g.m-2.day-1), stability under wet conditions and antibacterial activity according to the standard guidelines. The filters showed structural stability up to 2 h of washing and improved antibacterial activity against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) for optimized concentrations of MgO and CuO NPs. Overall, electrospun meshes with antibacterial activity were successfully developed for advanced filtering applications.

2022Journal article

Open access