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Browsing ESTG - Artigos em revistas internacionais by Sustainable Development Goals (SDG) "09:Indústria, Inovação e Infraestruturas"
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- 3D bioprinting of photocrosslinkable hydrogel constructsPublication . Brás Pereira, Rúben Filipe; Bartolo, PauloThree‐dimensional (3D) bioprinting comprises a group of biofabrication technologies for the additive manufacturing of 3D constructs by precisely printing biocompatible materials, cells and biochemicals in predesigned spatial positions. These technologies have been successfully applied to fabricate biodegradable 3D constructs with intricate architectures and heterogeneous composition, assuming a pivotal role in the field of tissue engineering. However, the full implementation of bioprinting strongly depends on the development of novel biomaterials exhibiting fast crosslinking schemes and appropriate printability, cell‐compatibility and biomechanical properties. Photocrosslinkable hydrogels are attractive materials for bioprinting as they provide fast polymerization under cell‐compatible conditions and exceptional spatiotemporal control over the gelation process. Photopolymerization can also be performed during the bioprinting to promote the instantaneous formation of hydrogel with high well‐defined architecture and structural stability. In this review paper, we summarize the most recent developments on bioprinting of photocrosslinkable biodegradable hydrogels for tissue engineering, focusing on the chemical modification strategies and the combination of photocrosslinking reactions with other gelation modalities.
- 3D Photo-Fabrication for Tissue Engineering and Drug DeliveryPublication . Brás Pereira, Rúben Filipe; Bartolo, PauloThe most promising strategies in tissue engineering involve the integration of a triad of biomaterials, living cells, and biologically active molecules to engineer synthetic environments that closely mimic the healing milieu present in human tissues, and that stimulate tissue repair and regeneration. To be clinically effective, these environments must replicate, as closely as possible, the main characteristics of the native extracellular matrix (ECM) on a cellular and subcellular scale. Photo-fabrication techniques have already been used to generate 3D environments with precise architectures and heterogeneous composition, through a multi-layer procedure involving the selective photocrosslinking reaction of a light-sensitive prepolymer. Cells and therapeutic molecules can be included in the initial hydrogel precursor solution, and processed into 3D constructs. Recently, photo-fabrication has also been explored to dynamically modulate hydrogel features in real time, providing enhanced control of cell fate and delivery of bioactive compounds. This paper focuses on the use of 3D photo-fabrication techniques to produce advanced constructs for tissue regeneration and drug delivery applications. State-of-the-art photo-fabrication techniques are described, with emphasis on the operating principles and biofabrication strategies to create spatially controlled patterns of cells and bioactive factors. Considering its fast processing, spatiotemporal control, high resolution, and accuracy, photo-fabrication is assuming a critical role in the design of sophisticated 3D constructs. This technology is capable of providing appropriate environments for tissue regeneration, and regulating the spatiotemporal delivery of therapeutics.
- 3D printing of new biobased unsaturated polyesters by microstereo-thermal-lithographyPublication . Gonçalves, Filipa A. M. M.; Costa, Cátia S. M. F.; Fabela, Inês G. P.; Farinha, Dina; Faneca, Henrique; Simões, Pedro N.; Serra, Arménio C.; Bártolo, Paulo J.; Coelho, Jorge F. J.New micro three-dimensional (3D) scaffolds using biobased unsaturated polyesters (UPs) were prepared by microstereo-thermal-lithography (μSTLG). This advanced processing technique offers indubitable advantages over traditional printing methods. The accuracy and roughness of the 3D structures were evaluated by scanning electron microscopy and infinite focus microscopy, revealing a suitable roughness for cell attachment. UPs were synthesized by bulk polycondensation between biobased aliphatic diacids (succinic, adipic and sebacic acid) and two different glycols (propylene glycol and diethylene glycol) using fumaric acid as the source of double bonds. The chemical structures of the new oligomers were confirmed by proton nuclear magnetic resonance spectra, attenuated total reflectance Fourier transform infrared spectroscopy and matrix assisted laser desorption/ionization-time of flight mass spectrometry. The thermal and mechanical properties of the UPs were evaluated to determine the influence of the diacid/glycol ratio and the type of diacid in the polyester's properties. In addition an extensive thermal characterization of the polyesters is reported. The data presented in this work opens the possibility for the use of biobased polyesters in additive manufacturing technologies as a route to prepare biodegradable tailor made scaffolds that have potential applications in a tissue engineering area.
- 3SqAir Project: A Living Lab Towards Sustainable Smart Strategy for Indoor Climate Quality Assurance in ClassroomsPublication . Ogundiran, James; Nyembwe, Jean-Paul Kapuya Bulaba; Ogundiran, John Omomoluwa; De Souto Santos, Rúben Alexandre; Pereira, Luísa Dias; Silva, Manuel Gameiro daThe indoor climate quality in classrooms at the University of Coimbra, Portugal, was investigated as part of the 3SqAir project, supported by the Interreg SUDOE program. This research focused on two equipped classrooms with different ventilation systems: natural and mechanical ventilation. Both classrooms were continuously monitored for IEQ parameters: thermal comfort, indoor air quality, noise, and lighting during heating and cooling seasons. Air temperature, relative humidity, CO2 concentration, particulate matter, nitrogen dioxide, volatile organic compounds, formaldehyde, sound pressure level, and illuminance were measured. Outdoor weather conditions were also recorded. The primary focus was on air temperature, CO2 concentrations, and relative humidity, while air change rates (ACH) were estimated using the Tracer Gas Method. The results showed inadequate thermal conditions in both classrooms, particularly during the heating season. Most weekly mean CO2 concentrations were within acceptable limits, while ACH were below standard recommendations in four CO2 decay phases. Simulations of CO2 decay revealed further air quality gaps in each room. Corrective measures within the 3SqAir project framework were suggested for approval and implementation while monitoring continues. This work represents the first phase in an evolving study towards developing sustainable strategies for improving indoor air quality in classrooms.
- A Software-Defined Radio for Future Wireless Communication Systems at 60 GHzPublication . Gomes, Rodolfo; Duarte, Luis; Ribeiro, Carlos; Caldeirinha, RafaelThis paper reports on a complete end-to-end 5G mmWave testbed fully reconfigurable based on a FPGA architecture. The proposed system is composed of a baseband/low-IF processing unit, and a mmWave RF front-end at both TX/RX ends. In particular, the baseband unit design is based on a typical agile digital IF architecture, enabling on-the-fly modulations up to 256-QAM. The real-time 5G mmWave testbed, herein presented, adopts OFDM as the transmission scheme waveform, which was assessed OTA by considering the key performance indicators, namely EVM and BER. A detailed overview of system architecture is addressed together with the hardware considerations taken into account for the mmWave testbed development. Following this, it is demonstrated that the proposed testbed enables real-time multi-stream transmissions of UHD video content captured by nine individual cameras, which is in fact one of the killing applications for 5G.
- An Automated Repository for the Efficient Management of Complex DocumentationPublication . Frade, José; Antunes, MárioThe accelerating digitalization of the public and private sectors has made information technologies (IT) indispensable in modern life. As services shift to digital platforms and technologies expand across industries, the complexity of legal, regulatory, and technical requirement documentation is growing rapidly. This increase presents significant challenges in managing, gathering, and analyzing documents, as their dispersion across various repositories and formats hinders accessibility and efficient processing. This paper presents the development of an automated repository designed to streamline the collection, classification, and analysis of cybersecurity-related documents. By harnessing the capabilities of natural language processing (NLP) models—specifically Generative Pre-Trained Transformer (GPT) technologies—the system automates text ingestion, extraction, and summarization, providing users with visual tools and organized insights into large volumes of data. The repository facilitates the efficient management of evolving cybersecurity documentation, addressing issues of accessibility, complexity, and time constraints. This paper explores the potential applications of NLP in cybersecurity documentation management and highlights the advantages of integrating automated repositories equipped with visualization and search tools. By focusing on legal documents and technical guidelines from Portugal and the European Union (EU), this applied research seeks to enhance cybersecurity governance, streamline document retrieval, and deliver actionable insights to professionals. Ultimately, the goal is to develop a scalable, adaptable platform capable of extending beyond cybersecurity to serve other industries that rely on the effective management of complex documentation.
- Autonomous Wireless Sensor with a Low Cost TEG for Application in Automobile VehiclesPublication . Costa, A.; Costa, D.; Morgado, J.; Santos, Helder; Ferreira, Carlos Daniel HenriquesThe present work consists in the development of an autonomous, low cost, reliable, energy scavenger sensor for automotive applications. Thermoelectric generators typically exhibit low efficiency but high reliability, making them suitable for autonomous, low average energy consumption, applications. A prototype sensor was developed for mounting in the engine exhaust pipe using a step-up voltage converter, a microcontroller, temperature and pressure sensing elements, conditioning electronics and a wireless transceiver, all powered by a low cost TEG (Peltier module TEC1-12706), through the scavenging of exhaust gases thermal energy. During the tests the prototype was able to sustain a regular signal transmission throughout the engine operation. The sensor was installed directly at the measuring point eliminating wired cables to hot and vibrating parts, thus, simplifying the installation of components and improving the reliability of the vehicle systems.
- Biomanufacturing for tissue engineering: Present and future trendsPublication . Bartolo, Paulo; Chua, C. K.; Almeida, Henrique de Amorim; Chou, S. M.; Lim, A. S. C.Tissue engineering, often referred to as regenerative medicine and reparative medicine, is an interdisciplinary field that necessitates the combined effort of cell biologists, engineers, material scientists, mathematicians, geneticists, and clinicians toward the development of biological substitutes that restore, maintain, or improve tissue function. It has emerged as a rapidly expanding approach to address the organ shortage problem and comprises tissue regeneration and organ substitution. Cells placed on/or within constructs is the most common strategy in tissue engineering. Successful cell seeding depends on fast attachment of cell to scaffolds, high cell survival and uniform cell distribution. The seeding time is strongly dependent on the scaffold material and architecture. Scaffolds provide an initial biochemical substrate for the novel tissue until cells can produce their own extra-cellular matrix (ECM). Thus scaffolds not only define the 3D space for the formation of new tissues, but also serve to provide tissues with appropriate functions. These scaffolds are often critical, both in vivo (within the body) or in vitro (outside the body) mimicking in vivo conditions. Additive fabrication processes represent a new group of non-conventional fabrication techniques recently introduced in the biomedical engineering field. In tissue engineering, additive fabrication processes have been used to produce scaffolds with customised external shape and predefined internal morphology, allowing good control of pore size and pore distribution. This article provides a comprehensive state-of-the-art review of the application of biomanufacturing additive processes in the field of tissue engineering. New and moving trends in biomanufacturing technologies and the concept of direct cell-printing technologies are also discussed.
- Carbon nanotubes in electrospun polyethylene oxide nanofibres: A potential route to conducting nanofibresPublication . Nazhipkyzy, M; Mohan, S D; Davis, F J; Mitchell, GeoffreyPolyethylene oxide solution containing multi-walled carbon nanotubes have been electrospun onto a rotating collector to produce highly aligned arrays of electrospun nanofibers ranging in diameters from (200 - 360) nanometres. The addition of a surfactant (Triton X-100) is highly effective in dispersing carbon nanotube within an aqueous solution of polyethylene oxide and the resulting mixture can be electrospun without excessive clumping to produce nanofibers containing high loadings of nanotubes; in this case up to 5% wt thereby providing an effective route to electrically conductive nanofibres.
- Comparative Analysis of Pressure Platform and Insole Devices for Plantar Pressure AssessmentPublication . Amaro, Catarina M.; Paulino, Maria F.; Valvez, Sara; Roseiro, Luis; Castro, Maria António; Amaro, Ana M.Foot plantar pressure refers to the pressure or force that the foot generates in contact with the ground, varying across different regions of the foot. This parameter is essential in static and dynamic analyses to access accurate diagnoses, study the human body biomechanics, create functional footwear designs, aid in rehabilitation and physiotherapy, and prevent injuries in athletes during sports practice. This study presents an experimental comparison between two different plantar pressure measurement devices, Pedar® (sensorized insoles) and Physiosensing® (pressure platform). The devices were selected based on their capacity to measure contact area and peak pressure points. Results showed that Physiosensing® provided a more uniform measurement of the contact area, proving its efficiency for weight distribution and stability analysis applications, particularly in posture assessment and balance studies. The Pedar® system showed higher capacity in peak pressure point detection. Therefore, the insole system is more suitable for applications requiring precise high-pressure zone localization. Comparative analysis highlights the strengths and limitations of each device and offers insights regarding its optimal usage in clinical, sports, and research settings.