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- European Journal of Heart Failure consensus statement. Heart failure pharmacotherapy for patients with heart failure with reduced ejection fraction and concomitant atrial fibrillation: Review of evidence and call to actionPublication . Luedde, Mark; Agewall, Stefan; Ambrosio, Giuseppe; Bayes‐Genis, Antoni; Borghi, Claudio; Cerbai, Elisabetta; Dan, Gheorghe A.; Drexel, Heinz; Ferdinandy, Péter; Grove, Erik Lerkevang; Kaski, Juan Carlos; Klingenberg, Roland; Morais, João; Parker, William; Petrie, Mark; Rocca, Bianca; Semb, Anne Grete; Senni, Michele; Sohns, Christian; Sulzgruber, Patrick; Tamargo, Juan; Metra, Marco; Böhm, Michael; Dobrev, Dobromir; Sossalla, SamuelHeart failure (HF) and atrial fibrillation (AF) are major global health challenges with rising prevalence and significant morbidity, mortality, and healthcare burden. Despite advances in HF management, AF remains a critical comorbidity that worsens outcomes and requires ad hoc treatment strategies, increasing the risk of non-adherence and side effects. While rhythm control strategies in AF have gained attention for their prognostic benefits in HF, the pharmacological treatment of HF in patients with AF, including the benefit of rhythm versus rate control, remains underexplored. The relationship between HF and AF lacks sufficient evidence and targeted research to assess the optimal treatment strategies. This narrative review critically examines current HF pharmacotherapy in the context of AF, focusing on the four cornerstone treatments and modifiers of prognosis for HF with reduced ejection fraction: beta-blockers, angiotensin-converting enzyme inhibitors/angiotensin receptor blockers/sacubitril-valsartan, aldosterone antagonists, and sodium–glucose co-transporter 2 inhibitors. Although these therapies are well-established in HF patients, their efficacy in patients with concomitant AF requires further prospective investigation. The unique challenges posed by AF, including arrhythmia-induced remodelling and cardiomyopathy, necessitate a more individually tailored treatment. We also highlight critical knowledge gaps and the need for dedicated clinical trials specifically assessing HF therapies in AF subgroups, such as paroxysmal, long-standing persistent and permanent AF, and the benefit of heart rate and rhythm control strategies. The future of precision medicine in HF-AF management lies in bridging these evidence gaps through targeted research and interdisciplinary collaboration.
- A Modular Approach for Object Segmentation and Image InpaintingSilva, Alexandre Santos; Ribeiro, José Carlos Bregieiro; Miragaia, Rolando Lúcio Germano; Silva, Fernando José Mateus da; Costa, Rogério Luís de CarvalhoIn this project, we propose ModInPainTor, a modular solution for object segmentation and removal in images. ModInPainTor takes advantage of advanced models from literature to deliver high-quality image inpainting results. This solution is inspired by InPainTor, a previous project that utilized a highly-integrated Convolutional Neural Network-based model for object detection and removal but lacked a comprehensive evaluation of its performance. We conduct a thorough evaluation of the InPainTor and ModInPainTor solutions, assessing their effectiveness in anonymizing visual data while maintaining data quality. The evaluation involves quantitative metrics to measure the quality of the results and a qualitative analysis to evaluate the visual quality of the anonymized images. Furthermore, we investigate the impact of object segmentation accuracy on the quality of the anonymized images. Our findings indicate that Mod- InPainTor significantly improves the visual quality of anonymized images compared to InPainTor, albeit with increased computational requirements. We find that the proposed solution could be effectively employed in industrial settings where anonymization quality is prioritized over computational efficiency.
- Atividades STEAM na promoção do desenvolvimento do Pensamento Computacional no 1.º CicloPublication . Pereira, Cecília Lopes; Cadima, Rita Alexandra DiasA educação STEAM no 1.º Ciclo do Ensino Básico emerge como uma estratégia essencial na preparação dos alunos para os desafios complexos, criativos e interdisciplinares do século XXI. Neste contexto, o presente projeto, desenvolvido no âmbito do Mestrado em Utilização Pedagógica das TIC, procurou explorar de que forma a integração de atividades STEAM pode promover o pensamento computacional e desenvolver competências transversais, em alunos do 4.º ano. A investigação baseou-se numa metodologia de Design-Based Research, que articula prática pedagógica e reflexão contínua, e assumiu ainda a metodologia de trabalho de projeto como estratégia orientadora das atividades em sala de aula. Partindo de um modelo pragmático, foram também considerados os desafios estruturais da escola, como a disponibilidade dos professores, o tempo letivo disponível e os recursos tecnológicos existentes, com vista à criação de soluções pedagógicas sustentáveis e inovadoras. As atividades implementadas ao longo de um semestre letivo foram concebidas para integrar diferentes áreas do saber, com foco na articulação entre Ciência, Tecnologia, Engenharia, Artes e Matemática. Desenvolveram-se propostas centradas na resolução de problemas reais e no uso de materiais reutilizáveis, envolvendo circuitos elétricos, motores, sensores e programação por blocos. As tarefas incluíram a construção de carrinhos elétricos, a criação de cartões eletrónicos com mensagens luminosas e atividades temáticas (como decorações de Natal com circuitos). As atividades foram sequenciadas de forma progressiva e articuladas com os conteúdos curriculares, promovendo o trabalho colaborativo, a exploração prática, a criatividade e o raciocínio lógico, sempre com um forte envolvimento dos alunos. A análise dos dados, recolhidos através de grelhas de registo, questionários e entrevistas, evidenciou um elevado grau de motivação e entusiasmo por parte dos alunos. Verificou-se um desenvolvimento visível de competências associadas ao pensamento computacional, nomeadamente a formulação de algoritmos, o reconhecimento de padrões e a abstração. Os alunos mostraram progressos significativos na colaboração, criatividade e autonomia. Apesar de algumas limitações técnicas e da necessidade de maior tempo para consolidação das aprendizagens, os resultados obtidos sugerem que a abordagem STEAM, com enfoque no pensamento computacional e sustentada por metodologias ativas, é eficaz e pertinente no contexto do 1.º Ciclo do Ensino Básico. Esta integração promove uma aprendizagem significativa, contextualizada e alinhada com as exigências da escola contemporânea e com os princípios de uma educação orientada para o futuro.
- How Transformational Leadership and Employer Branding increase Innovative Work BehaviorsPublication . Rocha, Tomás Rafael Pires; Sousa, Andrea Isabel Oliveira da Costa e; Ribeiro, Neuza Manuel PereiraInnovation is an important aspect for organizations to maintain their competitive edge. Organizations can look into their employees for a driver of innovation in the workplace. Employees drive innovation through innovative work behaviors, which can be stimulated by an organization through appropriate leadership or come more naturally to certain individuals. This work then seeks to understand how transformational leadership as a style of leadership influences innovative work behaviors and what kind of organization people who display more innovative work behaviors are most attracted towards, informing organizations on how employer branding can attract innovation through innovative workers. We surveyed 135 employees from Portuguese organizations to request their collaboration in answering a self-report questionnaire, and with this data, we found that transformational leadership has a positive impact on innovative work behaviors and that one subdimension of employer branding (interest value) is better at attracting employees who display more innovative work behaviors than the others. The novelty of this work comes from testing established knowledge in Portugal and from directly connecting innovative work behaviors and employer branding, something that hasn’t been done a lot before.
- Integration Development for SAP Business One: Internship Contributions at Be One SolutionsPublication . Antunes, Carolina Pazeiro; Ribeiro, José Carlos BregieiroThis report presents the activities and technical contributions developed during an internship at Be One Solutions, in the role of Junior Developer Intern. The core focus of the internship was the development of integration solutions for SAP Business One, utilizing both the BE1S Integration Platform and the Business One Integration Framework (B1if). Various integration scenarios were implemented using the BE1S platform, which supports C#-based module development and provides secure connectivity to file systems, SQL databases, and SAP Business One. Additionally, B1if was used to develop workflows utilizing its visual interface and XML/XSLT-based logic, enabling flexible and standardized data exchange. Beyond integration development, the internship also involved creating an installer for the BE1S platform, streamlining its deployment process, and documenting integration projects to ensure the clarity and maintainability of the implemented solutions. The report outlines the technical architecture of the platforms used, the challenges addressed throughout the projects, and the applied methodologies. The internship provided hands-on experience in enterprise integration, software development practices, and ERP system interaction within a professional environment.