Browsing by Issue Date, starting with "2025-05-21"
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- Assessing High-Value Bioproducts from Seaweed Biomass: A Comparative Study of Wild, Cultivated and Residual Pulp SourcesPublication . Ferreira, Henrique S.; Mouga, Teresa; Lourenço, Sílvia; Matias, Margarida H.; Freitas, Marta V.; Clélia Neves-AfonsoThis study aimed to evaluate the biochemical composition and bioactivities of biomass derived from wild (Laminaria ochroleuca and Saccorhiza polyschides) and cultivated (Macrocystis pyrifera) kelps, as well as industrially extracted residual pulp from M. pyrifera, to assess the potential production of high value bioproducts. All samples had a low lipid content, with M. pyrifera having the lowest (1.3% dw) and S. polyschides showing the highest value (3.3%). Fatty acids such as palmitic acid (C16:0), oleic acid (C18:1n-9 cis), alpha-linolenic acid (ALA, C18:3n-3), and eicosapentaenoic acid (EPA, C20:5n-3) were present, with the residual pulp having a distinctive n-6/n-3 ratio of less than one. The protein content was around 9% dry weight (dw) in all samples. The residual pulp and S. polyschides had the highest polyphenol content, with 4.86 and 4.94 mg GAE·g−1 extract, respectively. Hydroethanolic extracts (30–70%) confirmed Fe3+ reducing activity (FRAP) in all samples. These findings offer valuable insights on the biochemical composition and bioactivity of the kelp species under study and the residual kelp biomass (pulp), underlining their significant potential for applications in the field of Blue Biotechnology.
- Sustainable Tourism Marketing Through Destination Image: An AHP Approach for UNESCO Creative Cities in Gastronomy—The Case of Popayán, ColombiaPublication . Moreira, Pablo Henrique de Oliveira; Fraga, Carla; Lavandoski, Joice; Almeida, Paulo; Cardoso, LucíliaPopayán (Colombia) was the first city to be designated a UNESCO Creative City of Gastronomy in 2005, positioning itself as a symbolic ‘myth of origin’ within the network. In the context of growing demands for local strategies aligned with the Sustainable Development Goals (SDGs), it is pertinent to understand how founding cities manage and project their image through sustainable tourism marketing. Almost two decades later, this study examines how Popayán communicates and sustains its image within the UNESCO Creative Cities Network (UCCN), guided by sustainable tourism marketing principles. Methodologically, the study adopts an exploratory and descriptive case study approach, based on documentary analysis of institutional sources and the application of the adapted Analytic Hierarchy Process Image—UNESCO Creative City Gastronomy (AHPI-UCCG) model. The results provided the following: (1) a multidimensional analysis of Popayán’s image in the context of sustainable marketing; (2) an assessment of how the city’s image responds to current branding challenges, using the adapted AHPI-UCCG model; and (3) a proposal for a context-sensitive investment agenda aligned with sustainability objectives. These results support the development of a personalised strategy for Popayán and demonstrate the potential of this approach to inform analyses of other Creative Cities of Gastronomy, while recognising the unique symbolic role of Popayán as the foundational case.
- Antithrombotic treatment following revascularization for chronic limb-threatening ischaemia: a scientific statement of the European Society of Cardiology Working Group on Aorta and Peripheral Vascular Diseases and the European Society of Cardiology Working Group on Cardiovascular PharmacotherapyPublication . Schlager, Oliver; De Carlo, Marco; Mazzolai, Lucia; Bura-Riviere, Alessandra; Heiss, Christian; Palomares, Jose Rodriguez; Morais, João C. A.; Steiner, Sabine; Brodmann, Marianne; Aboyans, Victor; Caterina, Raffaele DeChronic limb-threatening ischaemia (CLTI) is defined as ischaemic rest pain, or non-healing ulceration, requiring endovascular or surgical lower limb revascularization (LLR). Lower limb revascularization in CLTI entails a high risk of major adverse limb events (MALE) and major adverse cardiovascular events (MACE). This scientific statement addresses this risk based on a systematic review. A structured literature search was performed, and articles were independently evaluated by two investigators. In total, 1678 articles were identified, of which 34 were included in the final analysis. Only three randomized controlled trials (RCTs) addressed antithrombotic therapy in CLTI following LLR. None of these demonstrated superiority of any antithrombotic regimen over the other. Eight RCTs investigated antithrombotic therapy following LLR in populations with peripheral arterial disease including CLTI subgroups and suggest a benefit of dual antiplatelet therapy on limb events. One large RCT demonstrated that dual pathway inhibition with aspirin and vascular-dose rivaroxaban reduced the risk of MALE, MACE, and unplanned target limb revascularization. Data from 22 observational studies suggest a benefit of dual antiplatelet therapy on overall survival and amputation-free survival after LLR as compared with single antiplatelet therapy. Intensified antithrombotic treatment should be proposed in patients with CLTI following LLR to reduce the risk of MALE and MACE. Randomized controlled trials on antithrombotic therapy in patients with CLTI following LLR are scarce. Dual pathway inhibition is the only regimen for which an RCT demonstrated a reduction of MALE and MACE following LLR. Dual antiplatelet therapy appears to be associated with a reduced risk of MALE in CLTI following LLR.