Percorrer por autor "Lima, Jorge"
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- PLAYER – a European Project and a Game to Foster Entrepreneurship Education for Young PeoplePublication . Fonseca, Benjamim; Morgado, Leonel; Paredes, Hugo; Martins, Paulo; Gonçalves, Ramiro; Neves, Pedro; Nunes, Ricardo Rodrigues; Lima, Jorge; Varajão, João; Pereira, Angela; Sanders, Robert; Barracho, Vera; Lapajne, Urban; Rus, Matej; Rahe, Martin; Mostert, Andre; Klein, Thorsten; Bojovic, Viktorija; Bošnjak, Saša; Bošnjak, Zita; Carvalho, João; Duarte, Isabel; Casaramona, Andreana; Soraci, AlbertoEntrepreneurship is widely recognized as one of the basic skills to be acquired through a life-long learning. The European Union, under the guidance of the Oslo Agenda, promotes several initiatives to develop entrepreneurship culture in Europe. Education can make a significant contribution to entrepreneurship, encouraging the development of ntrepreneurial attitudes and skills in young people. Serious Games are presently recognised as having an important role and potential in education and social networks emerged in the last years as the platform preferred by many, especially young people, to socialize, play games and even learn. This paper presents the PLAYER project, in which a game was developed and implemented as a Facebook application, to enable learning entrepreneurial skills progressively, by guiding users to develop a business idea in the form of a business plan.
- Prognosis of polymerase epsilon (POLE) mutation in high-grade endometrioid endometrial cancer: Systematic review and meta-analysisPublication . Casanova, Joao; Duarte, Gonçalo Silva; da Costa, Ana Gomes; Catarino, Ana; Nave, Mónica; Antunes, Telma; Serra, Sofia Silvério; Dias, Sara Simões; Abu-Rustum, Nadeem; Lima, JorgeBackground. POLE mutated endometrial carcinomas may represent a subspecific type of tumors harboring a more favorable prognosis. Grade 3 (G3 or high-grade) endometrioid endometrial carcinomas remain a clinical dilemma, with some tumors behaving as the low-grade counterparts and others presenting a more aggressive behavior. Objectives. To determine the association between POLE mutational status and the overall-survival (OS) and progression-free-survival (PFS) of patients with G3endometrioidendometrial cancer(EC). Wealsoaimed todetermine the prevalence of POLE mutations in G3 endometrioid EC. Methods. We conducted a systematic review in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines (PROSPERO No: CRD4202340008). We searched the following electronic databases: PubMed/Medline, EMBASE, Cochrane Library, Scopus, and Webof Science. For time-to-event data, the effect of POLE mutation in G3 EC was described using hazard ratios (HRs) and corresponding 95% confidence intervals (CIs). Individual patient data for each study was investigated if available from the study authors. If individual patient data were not available, information regarding time-to-event outcomes was extracted usinganappropriatemethodology.OSandPFSwereanalyzed using both one-stage and two-stage approaches, the Kaplan-Meier method, and Cox-proportional hazards models. Results. This systematicreviewandmeta-analysisincluded19studieswith3092patientswhohadhighgrade endometrioid EC. Patients with POLE mutations had lower risks of death (HR = 0.36, 95% CI 0.26 to 0.50, I2 = 0%, 10 trials) and disease progression (HR = 0.31, 95% CI 0.17 to 0.57, I2 =33%,10trials).The pooled prevalence of POLE mutation was 11% (95% CI 9 to 13, I2 = 68%, 18 studies).