Browsing by Author "Filho, Rubens Maciel"
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- Optimization of Scaffolds in Alginate for Biofabrication by Genetic AlgorithmsPublication . Rezende, Rodrigo; Rezende, Mylene; Bártolo, Paulo; Mendes, Ausenda; Filho, Rubens Maciel; Bartolo, Paulo; Mendes, AusendaWith an increasing in the rate of transplants due to damaged or affected tissues or organs by accidents or diseases and also by the aging of the population in many countries as Brazil, have motivated the research of some novel and alternative ways focused on restoring and replacing tissues. Biofabrication by means of Rapid Prototyping techniques can help in the fashioning and final production of scaffolds devoted to support and stimulate the growth of new tissues. For soft tissues, a biomaterial known as Alginate has been studied and used as raw-material for scaffolds fabrication. A scaffold must guarantee good strength and stiffness at the same time the material degrades gradually. In this work, a single mathematical model experimentally obtained that describes an interesting mechanical behavior of the degradation of alginated-scaffolds is developed. The optimization process scheme using Genetic Algorithms to maximize the elastic modulus and therefore to aid the design of scaffolds in alginate is proposed. The optimization is very welcome to tissue engineering and Biofabrication.
- Rheological behavior of alginate solutions for biomanufacturingPublication . Rezende, Rodrigo Alvarenga; Bartolo, Paulo; Mendes, Ausenda; Filho, Rubens MacielThe rheological behavior of alginate solutions were investigated for the optimal design of a biomanufacturing system to produce alginate structures for tissue engineering. Its rheological properties were determined by a rheometer through rotational and oscillatory I tests. Experimental results were used to model the alginate solutions characteristics. The findings suggest that alginate solutions undergo shear-thinning effects with increasing shear rates. It is also possible to observe that its loss modulus is higher than the storage modulus ones being both modulus dependent upon the frequency, which is a typical characteristic of dilute solutions.