Percorrer por autor "Baena-Gonzalez, Elena"
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- Mechanisms of regulation of SNF1/AMPK/SnRK1 protein kinasesPublication . Crozet, Pierre; Margalha, Leonor; Confraria, Ana; Rodrigues, Américo; Martinho, Cláudia; Adamo, Mattia; Elias, Carlos A.; Baena-Gonzalez, ElenaTheSNF1(sucrosenon-fermenting1)-relatedproteinkinases1(SnRKs1)aretheplantorthologsofthebuddingyeastSNF1andmammalianAMPK(AMP- activatedproteinkinase).Theseevolutionarilyconservedkinasesaremetabolicsensorsthatundergoactivationinresponsetodecliningenergylevels.Uponactivation,SNF1/AMPK/SnRK1kinasestriggeravasttranscriptionalandmetabolicreprogramingthatrestoresenergyhomeostasisandpromotestolerancetoadverseconditions,partlythroughaninductionofcatabolicprocessesandageneralrepressionofanabolism.Thesekinasestypicallyfunctionasaheterotrimericcomplexcomposedoftworegulatorysubunits,βandγ,andanα-catalyticsubunit,whichrequiresphosphorylationofaconservedactivationloopresidueforactivity.Additionally,SNF1/AMPK/SnRK1kinasesarecontrolledbymultiplemechanismsthathaveanimpactonkinaseactivity,stability,and/orsubcellularlocalization.HerewewillreviewcurrentknowledgeontheregulationofSNF1/AMPK/SnRK1byupstreamcomponents,post-translationalmodifications,variousmetabolites,hormones,andothers,inanattempttohighlightboththecommonalitiesoftheseessentialeukaryotickinasesandthedivergencesthathaveevolvedtocopewiththeparticularitiesofeachoneofthesesystems.