ESTG - Capítulos de livros
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Percorrer ESTG - Capítulos de livros por autor "Almeida, H.A."
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- Geometric and structural comparison of anatomic modelsPublication . Zeibak, R.; Freitas, D.; Almeida, H.A.; Bártolo, P.Computer Aided Design in the medical field helps translating CT and MRI data into anatomical 3D reconstructions. Accurate 3D models are valuable tools in several medical domains, thus finding accurate 3D reconstructions have profound advantages in all of the existing medical fields. The main objective of this research is to compare existing medical imaging processing softwares and evaluating their influence regarding both geometric deviations and numerical structural simulations between the 3D resulting models of both softwares.
- Optimization of a perfusion bioreactor for tissue engineeringPublication . Freitas, D.; Almeida, H.A.; Bártolo, P.Tissue engineering aims to produce artificial tissue in order to create or repair the damage tissue. It is evident that scaffolds are of extreme importance, because they will be the support of the new tissue. This new tissue is cultivated in vitro in a bioreactor in which is placed the scaffold. In order to control the cell culture process inside of a bioreactor it is essential to know the fluid flow inside and around the scaffold and the respective wall shear stress. These wall shear stress must be adequate to the tissue to be cultivated, i.e., bone, muscle, cartilage and it is known that a proper stimulus is necessary to improve the cell proliferation inside the scaffold. This study consider a novel multifunctional bioreactor with a perfusion system module and it is intended to optimize the fluid flow within the scaffold and the respective wall shear stress on the scaffold.
- Permeability Evaluation of Flow Behaviors Within Perfusion BioreactorsPublication . Freitas, D.; Almeida, H.A.; Bártolo, P. J.Tissue engineering aims to produce artificial tissue in order to create or repair damaged tissue. It is evident that scaffolds are of extreme importance, because they will be the support structure of the new tissue. This new tissue is cultivated in vitro in a bioreactor in which is placed the scaffold. In order to control the cell culture process inside of a bioreactor, it is essential to know the fluid flow inside the scaffold for an adequate exchange of nutrients and metabolic waste. A novel multifunctional bioreactor with a perfusion system module comprised of three different inlet and outlet membranes is being developed. This research work will evaluate the permeability of the scaffold under the three different inlet and outlet diffusion membranes of the culture chamber.
- Structural Shear Stress Evaluation of Triple Periodic Minimal SurfacesPublication . Almeida, H.A.; Bártolo, P. J.Tissue engineering represents a new, emerging interdisciplinary field involving combined efforts of several scientific domains towards the development of biological substitutes to restore, maintain, or improve tissue functions. Scaffolds provide a temporary mechanical and vascular support for tissue regeneration while shaping the in-growth tissues. These scaffolds must be biocompatible, biodegradable, with appropriate porosity, pore structure and pore distribution and optimal structural and vascular performance, having both surface and structural compatibility. Surface compatibility means a chemical, biological and physical suitability to the host tissue. Structural compatibility corresponds to an optimal adaptation to the mechanical behaviour of the host tissue. The design of optimised scaffolds based on the fundamental knowledge of its macro microstructure is a relevant topic of research. This research proposes the use of geometric structures based on Triple Periodic Minimal Surfaces for Shear Stress applications. Geometries based on these surfaces enables the design of vary high surface-to-volume ratio structures with high porosity and mechanical/vascular properties. Previous work has demonstrated the potential of Schwartz and Schoen surfaces in tensile/compressive solicitations, when compared to regular geometric based scaffolds. The main objective is to evaluate the same scaffold designs under shear stress solicitations varying the thickness and radius of the scaffold’s geometric definition.