ESTG - Capítulos de livros
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Browsing ESTG - Capítulos de livros by Author "Almeida, H.A."
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- Permeability Evaluation of Flow Behaviors Within Perfusion BioreactorsPublication . Freitas, D.; Almeida, H.A.; Bártolo, P. J.Tissue engineering aims to produce artificial tissue in order to create or repair damaged tissue. It is evident that scaffolds are of extreme importance, because they will be the support structure of the new tissue. This new tissue is cultivated in vitro in a bioreactor in which is placed the scaffold. In order to control the cell culture process inside of a bioreactor, it is essential to know the fluid flow inside the scaffold for an adequate exchange of nutrients and metabolic waste. A novel multifunctional bioreactor with a perfusion system module comprised of three different inlet and outlet membranes is being developed. This research work will evaluate the permeability of the scaffold under the three different inlet and outlet diffusion membranes of the culture chamber.
- Structural Shear Stress Evaluation of Triple Periodic Minimal SurfacesPublication . Almeida, H.A.; Bártolo, P. J.Tissue engineering represents a new, emerging interdisciplinary field involving combined efforts of several scientific domains towards the development of biological substitutes to restore, maintain, or improve tissue functions. Scaffolds provide a temporary mechanical and vascular support for tissue regeneration while shaping the in-growth tissues. These scaffolds must be biocompatible, biodegradable, with appropriate porosity, pore structure and pore distribution and optimal structural and vascular performance, having both surface and structural compatibility. Surface compatibility means a chemical, biological and physical suitability to the host tissue. Structural compatibility corresponds to an optimal adaptation to the mechanical behaviour of the host tissue. The design of optimised scaffolds based on the fundamental knowledge of its macro microstructure is a relevant topic of research. This research proposes the use of geometric structures based on Triple Periodic Minimal Surfaces for Shear Stress applications. Geometries based on these surfaces enables the design of vary high surface-to-volume ratio structures with high porosity and mechanical/vascular properties. Previous work has demonstrated the potential of Schwartz and Schoen surfaces in tensile/compressive solicitations, when compared to regular geometric based scaffolds. The main objective is to evaluate the same scaffold designs under shear stress solicitations varying the thickness and radius of the scaffold’s geometric definition.