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Box-Behnken Design a Key Tool to Achieve Optimized PCL/Gelatin Electrospun Mesh, Macromolecular Materials and Engineering

2021-02-19Journal article Open access
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dc.contributor.authorGuerreiro, S.F.C.
dc.contributor.authorValente, J.F.A.
dc.contributor.authorDias, J.R.
dc.contributor.authorAlves, N.
dc.date.accessioned2023-03-17T19:42:30Z
dc.date.available2023-03-17T19:42:30Z
dc.date.issued2021-02-19
dc.description.abstractHybrid electrospun nanofibers of polycaprolactone (PCL)/gelatin are considered as drug-delivery systems for increasing the treatment efficacy in superficial (skin) wounds. Continuous delivery of therapeutic agents, skin extracellular matrix similarity, management of wound exudate, and antimicrobial barrier effect are the major advantages of electrospun nanofibers in skin applications. Additionally, combining the favorable properties of PCL and gelatin, regarding their biocompatibility, biodegradability and mechanical performance have been revealed promising parameters to be considered for blend in hybrid structures. However, the usual optimization protocol of nanofibers’ production in electrospinning is based on the observation of one-variable-attime being this methodology expensive and time-consuming. Therefore, in this research work, a statistical model based on four input variables namely, the flow rate, the needle-working distance, the applied voltage, and the ratio of PCL in the solution, is developed to predict the behavior of nanofibers. The performance of nanofibers is monitored by measurements of fiber’s diameter, mesh’s thickness, and mesh’s permeability. Overall, the model showed to be statistically significant (p-value < 0.05) and an independent analysis validated the predicted response for optimal condition. Finally, a delivery study is performed to evaluate the electrospun mesh performance as a drug carrier.en
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationS. F. C. Guerreiro, Dr. J. F. A. Valente, Dr. J. R. Dias, Prof. N. Alves Centre for Rapid and Sustainable Product Development Polytechnic Institute of Leiria Marinha Grande, Leiria 2430-028, Portugal E-mail: sara.f.guerreiro@ipleiria.ptpt_PT
dc.identifier.doi10.1002/mame.202000678pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.8/8255
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.titleBox-Behnken Design a Key Tool to Achieve Optimized PCL/Gelatin Electrospun Mesh, Macromolecular Materials and Engineeringpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleMacromolecular materials and engineeringpt_PT
oaire.citation.volumeVol. 306, n.º 4pt_PT
person.familyNameGuerreiro
person.familyNameValente
person.familyNameDias
person.familyNameAlves
person.givenNameSara
person.givenNameJoana
person.givenNameJuliana
person.givenNameNuno
person.identifier826126
person.identifier633669
person.identifier452149
person.identifier.ciencia-id7219-29B5-2DDF
person.identifier.ciencia-id7515-7468-212D
person.identifier.ciencia-id0612-D971-F00D
person.identifier.ciencia-id311E-1559-8F6C
person.identifier.orcid0000-0002-6652-2376
person.identifier.orcid0000-0002-2408-9762
person.identifier.orcid0000-0002-7079-1069
person.identifier.orcid0000-0002-5016-0868
person.identifier.ridM-1930-2019
person.identifier.ridA-6086-2014
person.identifier.ridN-4073-2013
person.identifier.scopus-author-id56273710100
person.identifier.scopus-author-id55749822200
person.identifier.scopus-author-id7006403383
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication.latestForDiscoverye8da7fc4-70f6-4772-a418-c58b0389dea3

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