Logo do repositório
 
Publicação

Cell Therapy with Human MSCs Isolated from the Umbilical Cord Wharton Jelly Associated to a PVA Membrane in the Treatment of Chronic Skin Wounds

2014-07-11Artigo científico Acesso aberto
Ver registo simples
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
datacite.subject.sdg12:Produção e Consumo Sustentáveis
dc.contributor.authorRibeiro, Jorge
dc.contributor.authorPereira, Tiago
dc.contributor.authorAmorim, Irina
dc.contributor.authorCaseiro, Ana Rita
dc.contributor.authorLopes, Maria A.
dc.contributor.authorLima, Joana
dc.contributor.authorGartner, Andrea
dc.contributor.authorDomingos Santos, José Domingos
dc.contributor.authorBártolo, Paulo J.
dc.contributor.authorRodrigues, Jorge Manuel
dc.contributor.authorMauricio, Ana Colette
dc.contributor.authorLuís, Ana Lúcia
dc.date.accessioned2026-06-23T14:37:26Z
dc.date.available2026-06-23T14:37:26Z
dc.date.issued2014-07-11
dc.description.abstractThe healing process of the skin is a dynamic procedure mediated through a complex feedback of growth factors secreted by a variety of cells types. Despite the most recent advances in wound healing management and surgical procedures, these techniques still fail up to 50%, so cellular therapies involving mesenchymal stem cells (MSCs) are nowadays a promising treatment of skin ulcers which are a cause of high morbidity. The MSCs modulate the inflammatory local response and induce cell replacing, by a paracrine mode of action, being an important cell therapy for the impaired wound healing. The local application of human MSCs (hMSCs) isolated from the umbilical cord Wharton's jelly together with a poly(vinyl alcohol) hydrogel (PVA) membrane, was tested to promote wound healing in two dogs that were referred for clinical examination at UPVET Hospital, showing non-healing large skin lesions by the standard treatments. The wounds were infiltrated with 1000 cells/µl hMSCs in a total volume of 100 µl per cm2 of lesion area. A PVA membrane was applied to completely cover the wound to prevent its dehydration. Both animals after the treatment demonstrated a significant progress in skin regeneration with decreased extent of ulcerated areas confirmed by histological analysis. The use of Wharton's jelly MSCs associated with a PVA membrane showed promising clinical results for future application in the treatment of chronic wounds in companion animals and humans.eng
dc.description.sponsorshipThe authors would like to thanks to the owners of Kika and Sunny. I Amorim (SFRH/BD/76237/2011) acknowledge FCT, the Portuguese Foundation for Science and Technology, for financial support. The Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP) is an Associate Laboratory of the Portuguese Ministry of Science, Technology and Higher Education and is partially supported by FCT. This research was supported by QREN I&DT Cluster in Development of Products for Regenerative Medicine and Cell Therapies – Projects Biomat & Cell QREN 2008/1372, co-financed by the European Community FEDER fund through ON2 - O Novo Norte – North Portugal Regional Operational Program 2007-2013, by project "Hybrid Nanostructured Hydrogels: Bone regeneration using Multifunctional injectable Hydrogels - Rebone" – ENMED/0002/2010 from FCT, Ministério da Educação e da Ciência and Program Project Euronanomed, Ref: EraNet - EuroNanoMed JTC2010, and by the program COMPETE – Programa Operacional Factores de Competitividade, Project Pest-OE/AGR/UI0211/2011.
dc.identifier.citationRibeiro, J., Pereira, T., Amorim, I., Caseiro, A.R., Lopes, M.A., Lima, J., Gartner, A., Santos, J.D., Bártolo, P.J., Rodrigues, J.M., Mauricio, A.C., Luís, A.L. (2014). Cell Therapy with Human MSCs Isolated from the Umbilical Cord Wharton Jelly Associated to a PVA Membrane in the Treatment of Chronic Skin Wounds. International Journal of Medical Sciences, 11(10), 979-987. https://doi.org/10.7150/ijms.9139
dc.identifier.doi10.7150/ijms.9139
dc.identifier.issn1449-1907
dc.identifier.urihttp://hdl.handle.net/10400.8/16447
dc.language.isoeng
dc.peerreviewedyes
dc.publisherIvyspring International Publisher
dc.relationHELICOBACTER SPP. INFECTION IN PETS - AN EPIDEMIOLOGICAL, MOLECULAR AND PREVENTIVE STUDY
dc.relationHybrid Nanostuctured Hydrogels: Bone regeneration using multifunctional injectable hydrogels
dc.relationStrategic Project - UI 211 - 2011-2012
dc.relation.hasversionhttps://www.medsci.org/v11p0979.htm
dc.relation.ispartofInternational Journal of Medical Sciences
dc.rights.uriN/A
dc.subjectChronic wounds
dc.subjectMesenchymal stem cells
dc.subjectWharton’s jelly
dc.subjectPVA hydrogel
dc.subjectHistology
dc.titleCell Therapy with Human MSCs Isolated from the Umbilical Cord Wharton Jelly Associated to a PVA Membrane in the Treatment of Chronic Skin Woundseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberSFRH/BD/76237/2011
oaire.awardNumberENMED/0002/2010
oaire.awardNumberPEst-OE/AGR/UI0211/2011
oaire.awardTitleHELICOBACTER SPP. INFECTION IN PETS - AN EPIDEMIOLOGICAL, MOLECULAR AND PREVENTIVE STUDY
oaire.awardTitleHybrid Nanostuctured Hydrogels: Bone regeneration using multifunctional injectable hydrogels
oaire.awardTitleStrategic Project - UI 211 - 2011-2012
oaire.awardURIhttp://hdl.handle.net/10400.8/16237
oaire.awardURIhttp://hdl.handle.net/10400.8/16236
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FAGR%2FUI0211%2F2011/PT
oaire.citation.endPage987
oaire.citation.issue10
oaire.citation.startPage979
oaire.citation.titleInternational Journal of Medical Sciences
oaire.citation.volume11
oaire.fundingStreamEuroNanoMed - Second Joint Call 2010
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameCaseiro Santos
person.familyNameBartolo
person.givenNameAna Rita
person.givenNamePaulo
person.identifier203086
person.identifier.ciencia-id5810-9BF9-4522
person.identifier.orcid0000-0002-1143-2461
person.identifier.orcid0000-0003-3683-726X
person.identifier.ridF-2421-2013
person.identifier.scopus-author-id6603353041
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isAuthorOfPublication09f3013f-81ac-4c52-bdf6-2a3dc83f348f
relation.isAuthorOfPublicationab44d1ae-46d0-45c2-b19f-200024b5a990
relation.isAuthorOfPublication.latestForDiscovery09f3013f-81ac-4c52-bdf6-2a3dc83f348f
relation.isProjectOfPublication7cdbc8b7-2c70-459a-925a-b6037ab60f58
relation.isProjectOfPublication519e1433-eee0-4c09-a5d7-af671c2b12eb
relation.isProjectOfPublication4437bc48-d63a-4b86-a0b8-6f0ed06d9f36
relation.isProjectOfPublication.latestForDiscovery7cdbc8b7-2c70-459a-925a-b6037ab60f58

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura
Nome:
v11p0979.pdf
Tamanho:
1.74 MB
Formato:
Adobe Portable Document Format
Ver/Abrir
Licença
A mostrar 1 - 1 de 1
Miniatura indisponível
Nome:
license.txt
Tamanho:
1.32 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Ver/Abrir

Coleções

CDRsp - Artigos em revistas internacionais