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Hyperbaric Oxygen Therapy Improves Glucose Homeostasis in Type 2 Diabetes Patients: A Likely Involvement of the Carotid Bodies

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datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg17:Parcerias para a Implementação dos Objetivos
datacite.subject.sdg04:Educação de Qualidade
dc.contributor.authorVera-Cruz, P.
dc.contributor.authorGuerreiro, F.
dc.contributor.authorRibeiro, M.J.
dc.contributor.authorGuarino M.P.
dc.contributor.authorConde, S.V.
dc.date.accessioned2026-01-27T16:30:05Z
dc.date.available2026-01-27T16:30:05Z
dc.date.issued2015
dc.descriptionPart of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 860)
dc.description.abstractThe carotid bodies (CBs) are peripheral chemoreceptors that respond to hypoxia increasing minute ventilation and activating the sympathetic nervous system. Besides its role in ventilation we recently described that CB regulate peripheral insulin sensitivity. Knowing that the CB is functionally blocked by hyperoxia and that hyperbaric oxygen therapy (HBOT) improves fasting blood glucose in diabetes patients, we have investigated the effect of HBOT on glucose tolerance in type 2 diabetes patients. Volunteers with indication for HBOT were recruited at the Subaquatic and Hyperbaric Medicine Center of Portuguese Navy and divided into two groups: type 2 diabetes patients and controls. Groups were submitted to 20 sessions of HBOT. OGTT were done before the first and after the last HBOT session. Sixteen diabetic patients and 16 control individual were included. Fasting glycemia was143.5 ± 12.62 mg/dl in diabetic patients and 92.06 ± 2.99 mg/dl in controls. In diabetic patients glycemia post-OGTT was 280.25 ± 22.29 mg/dl before the first HBOT session. After 20 sessions, fasting and 2 h post-OGTT glycemia decreased significantly. In control group HBOT did not modify fasting glycemia and post-OGTT glycemia. Our results showed that HBOT ameliorates glucose tolerance in diabetic patients and suggest that HBOT could be used as a therapeutic intervention for type 2 diabetes.eng
dc.description.sponsorship
dc.identifier.citationVera-Cruz, P., Guerreiro, F., Ribeiro, M.J., Guarino, M.P., Conde, S.V. (2015). Hyperbaric Oxygen Therapy Improves Glucose Homeostasis in Type 2 Diabetes Patients: A Likely Involvement of the Carotid Bodies. In: Peers, C., Kumar, P., Wyatt, C., Gauda, E., Nurse, C., Prabhakar, N. (eds) Arterial Chemoreceptors in Physiology and Pathophysiology. Advances in Experimental Medicine and Biology, vol 860. Springer, Cham. https://doi.org/10.1007/978-3-319-18440-1_24
dc.identifier.doi10.1007/978-3-319-18440-1_24
dc.identifier.isbn9783319184395
dc.identifier.isbn9783319184401
dc.identifier.issn0065-2598
dc.identifier.issn2214-8019
dc.identifier.urihttp://hdl.handle.net/10400.8/15522
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSpringer Nature
dc.relation.hasversionhttps://link.springer.com/chapter/10.1007/978-3-319-18440-1_24
dc.relation.ispartofAdvances in Experimental Medicine and Biology
dc.relation.ispartofArterial Chemoreceptors in Physiology and Pathophysiology
dc.rights.uriN/A
dc.subjectGlucose tolerance
dc.subjectHyperbaric oxygen therapy
dc.subjectType 2 diabetes
dc.titleHyperbaric Oxygen Therapy Improves Glucose Homeostasis in Type 2 Diabetes Patients: A Likely Involvement of the Carotid Bodieseng
dc.typebook part
dspace.entity.typePublication
oaire.citation.endPage225
oaire.citation.startPage221
oaire.citation.titleArterial Chemoreceptors in Physiology and Pathophysiology
oaire.citation.volume860
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameGuarino
person.givenNameMaria Pedro
person.identifier.ciencia-idF21A-BD01-2D52
person.identifier.orcid0000-0001-6079-1105
person.identifier.ridB-5594-2015
person.identifier.scopus-author-id56348477000
relation.isAuthorOfPublicationf163d4df-1e45-4278-affa-5994f206becf
relation.isAuthorOfPublication.latestForDiscoveryf163d4df-1e45-4278-affa-5994f206becf

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