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Poly(ɛ-caprolactone) and Polyethylene Glycol Diacrylate-based Scaffolds for TMJ Bioengineered Disc Implants

2017Journal article Open access
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datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
datacite.subject.sdg12:Produção e Consumo Sustentáveis
dc.contributor.authorFrancisco, Luís
dc.contributor.authorMoura, Carla
dc.contributor.authorViana, Tânia
dc.contributor.authorÂngelo, David
dc.contributor.authorMorouço, Pedro
dc.contributor.authorAlves, Nuno
dc.date.accessioned2025-11-28T17:00:04Z
dc.date.available2025-11-28T17:00:04Z
dc.date.issued2017
dc.description.abstractThe temporomandibular joint (TMJ), articulation between the mandibular condyle and the temporal bone, is divided into two compartments (superior and inferior) by a fibrocartilaginous disc. The TMJ disc consists on an avascular and non-innervated tissue, with viscoelastic behavior. Mechanically, the TMJ disc experiences tensile, compressive and shear forces. TMJ disc displacement or degeneration could lead to severe intra-articular temporomandibular joint disorders (TMD). Despite the large number of current therapies/treatments, there is limited treatment options for severe intra-articular TMD. A strategy to solve this problem could be the use of an interposal material to substitute the damaged TMJ disc, which will gradually degrade and give rise to new tissue. In this work three options were used and tested, one using a thermoplastic material, poly(ε-caprolactone) (PCL), another using an photopolymerized hydrogel, polyethylene glycol diacrilate (PEGDA) and the third using the combination of the two materials. Obtained results demonstrated that that the combination of different materials could represent a significant advantage in the TMJ disc TE and in the cartilage TE in general.eng
dc.description.sponsorshipThis research work was supported by the Portuguese Foundation for Science and Technology (FCT) through the project UID/Multi/04044/2013 and through the projects POCI-01-0247-FEDER-017771.
dc.identifier.citationLuís Francisco, Carla Moura, Tânia Viana, David Ângelo, Pedro Morouço, Nuno Alves, Poly(ɛ-caprolactone) and Polyethylene Glycol Diacrylate-based Scaffolds for TMJ Bioengineered Disc Implants, Procedia Manufacturing, Volume 12, 2017, Pages 291-297, ISSN 2351-9789, https://doi.org/10.1016/j.promfg.2017.08.032
dc.identifier.doi10.1016/j.promfg.2017.08.032
dc.identifier.issn2351-9789
dc.identifier.urihttp://hdl.handle.net/10400.8/14796
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier BV
dc.relationCentre for Rapid and Sustainable Product Development
dc.relationPOCI-01-0247-FEDER-017771
dc.relation.hasversionhttps://www.sciencedirect.com/science/article/pii/S2351978917306212
dc.relation.ispartofProcedia Manufacturing
dc.rights.urihttp://creativecommons.org/licenses/by-nd/4.0/
dc.subjectTemporomandibular joint disc
dc.subjectPoly(ε-caprolactone)
dc.subjectPolyethylene glycol diacrilate
dc.subjectScaffold
dc.subjectHydrogel
dc.titlePoly(ɛ-caprolactone) and Polyethylene Glycol Diacrylate-based Scaffolds for TMJ Bioengineered Disc Implantseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre for Rapid and Sustainable Product Development
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F04044%2F2013/PT
oaire.citation.endPage297
oaire.citation.startPage291
oaire.citation.titleProcedia Manufacturing
oaire.citation.volume12
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameMonteiro de Moura
person.familyNameViana
person.familyNameÂngelo
person.familyNameMorouço
person.familyNameAlves
person.givenNameCarla Sofia
person.givenNameTânia
person.givenNameDavid
person.givenNamePedro
person.givenNameNuno
person.identifier435983
person.identifier452149
person.identifier.ciencia-id671C-8FEC-A14A
person.identifier.ciencia-idB41D-8BE0-7C9D
person.identifier.ciencia-id2C1B-F1D5-5A08
person.identifier.ciencia-idF619-3996-742A
person.identifier.ciencia-id311E-1559-8F6C
person.identifier.orcid0000-0003-2610-1005
person.identifier.orcid0000-0002-9688-647X
person.identifier.orcid0000-0001-8411-9946
person.identifier.orcid0000-0002-5956-9790
person.identifier.orcid0000-0002-5016-0868
person.identifier.ridO-1147-2013
person.identifier.ridK-9545-2013
person.identifier.ridN-4073-2013
person.identifier.scopus-author-id55885892100
person.identifier.scopus-author-id24339135400
person.identifier.scopus-author-id7006403383
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
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