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Inhalation of peptide-loaded nanoparticles improves heart failure

2018Journal article Open access
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dc.contributor.authorMiragoli, Michele
dc.contributor.authorCeriotti, Paola
dc.contributor.authorIafisco, Michele
dc.contributor.authorVacchiano, Marco
dc.contributor.authorSalvarani, Nicolò
dc.contributor.authorCarullo, Pierluigi
dc.contributor.authorRamírez-Rodríguez, Gloria Belén
dc.contributor.authorFernandes Patrício, Tatiana Marisa
dc.contributor.authorDegli Esposti, Lorenzo
dc.contributor.authorRossi, Francesca
dc.contributor.authorRavanetti, Francesca
dc.contributor.authorPinelli, Silvana
dc.contributor.authorAlinovi, Rossella
dc.contributor.authorErreni, Marco
dc.contributor.authorROSSI, Stefano
dc.contributor.authorCondorelli, Gianluigi
dc.contributor.authorPost, Heiner
dc.contributor.authorTAMPIERI, ANNA
dc.contributor.authorCatalucci, Daniele
dc.date.accessioned2023-11-15T17:50:50Z
dc.date.available2023-11-15T17:50:50Z
dc.date.issued2018
dc.description.abstractPeptides are highly selective and efficacious for the treatment of cardiovascular and other diseases. However, it is currently not possible to administer peptides for cardiac-targeting therapy via a noninvasive procedure, thus representing scientific and technological challenges. We demonstrate that inhalation of small (<50 nm in diameter) biocompatible and biodegradable calcium phosphate nanoparticles (CaPs) allows for rapid translocation of CaPs from the pulmonary tree to the bloodstream and to the myocardium, where their cargo is quickly released. Treatment of a rodent model of diabetic cardiomyopathy by inhalation of CaPs loaded with a therapeutic mimetic peptide that we previously demonstrated to improve myocardial contraction resulted in restoration of cardiac function. Translation to a porcine large animal model provides evidence that inhalation of a peptide-loaded CaP formulation is an effective method of targeted administration to the heart. Together, these results demonstrate that inhalation of biocompatible tailored peptide nanocarriers represents a pioneering approach for the pharmacological treatment of heart failure.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMichele Miragoli et al. ,Inhalation of peptide-loaded nanoparticles improves heart failure.Sci. Transl. Med.10,eaan6205(2018).DOI:10.1126/scitranslmed.aan6205pt_PT
dc.identifier.doihttps://www.science.org/doi/10.1126/scitranslmed.aan6205pt_PT
dc.identifier.eissn1946-6242
dc.identifier.issn1946-6234
dc.identifier.urihttp://hdl.handle.net/10400.8/8927
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAmerican Association for the Advancement of Sciencept_PT
dc.relation.ispartofseries424;
dc.relation.publisherversionhttps://www.science.org/doi/full/10.1126/scitranslmed.aan6205#bibliographypt_PT
dc.titleInhalation of peptide-loaded nanoparticles improves heart failurept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage12pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleScience Translational Medicinept_PT
oaire.citation.volume10pt_PT
person.familyNameMiragoli
person.familyNameIafisco
person.familyNameVacchiano
person.familyNamesalvarani
person.familyNamecarullo
person.familyNameRamírez-Rodríguez
person.familyNameFernandes Patrício
person.familyNameDegli Esposti
person.familyNameRossi
person.familyNameRavanetti
person.familyNamePinelli
person.familyNameAlinovi
person.familyNameErreni
person.familyNameROSSI
person.familyNameCondorelli
person.familyNameTAMPIERI
person.familyNameCatalucci
person.givenNameMichele
person.givenNameMichele
person.givenNameMarco
person.givenNamenicolò
person.givenNamepierluigi
person.givenNameGloria Belén
person.givenNameTatiana Marisa
person.givenNameLorenzo
person.givenNameFrancesca
person.givenNameFrancesca
person.givenNameSilvana
person.givenNameRossella
person.givenNameMarco
person.givenNameStefano
person.givenNameGianluigi
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person.givenNameDaniele
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