datacite.subject.fos	Ciências Médicas::Ciências da Saúde
datacite.subject.sdg	03:Saúde de Qualidade
datacite.subject.sdg	17:Parcerias para a Implementação dos Objetivos
dc.contributor.author	Guarino, Maria Pedro
dc.contributor.author	Sacramento, Joana
dc.contributor.author	Ribeiro, Maria João
dc.contributor.author	Conde, Sílvia Vilares
dc.date.accessioned	2026-03-02T16:04:08Z
dc.date.available	2026-03-02T16:04:08Z
dc.date.issued	2015
dc.description.abstract	In the last decades, we have witnessed a dramatic increase in the prevalence of obesity and obesity-associated diseases like type 2 diabetes and the metabolic syndrome. The role of caffeine in the pathogenesis of core features of these conditions―hypertension and insulin resistance―is still very controversial. A growing number of evidence shows that chronic caffeine intake has protective effects in the development of insulin resistance, glucose intolerance, and hypertension, in contrast with the effects of acute caffeine consumption, which are clearly deleterious. The mechanisms proposed for the protective effects of caffeine range from direct metabolic actions in the adipose tissue to more complex systemic effects mediated by inhibition of the carotid bodies. The discovery that caffeine modulates metabolic and vascular functions shed a new light into this field of research, which is currently a hot topic in the integrative approach to treat dysmetabolic states.	eng
dc.identifier.citation	Guarino, M., Sacramento, J., Ribeiro, M.J. & Conde, S. (2015). Chapter 83 - Caffeine, Insulin Resistance, and Hypertension, Editor(s): Victor R. Preedy, Coffee in Health and Disease Prevention, Academic Press, pp. 747-755, ISBN 9780124095175, https://doi.org/10.1016/B978-0-12-409517-5.00083-8
dc.identifier.doi	10.1016/b978-0-12-409517-5.00083-8
dc.identifier.isbn	978-012409517-5
dc.identifier.isbn	978-012416716-2
dc.identifier.uri	http://hdl.handle.net/10400.8/15756
dc.language.iso	eng
dc.peerreviewed	yes
dc.publisher	Elsevier
dc.relation.hasversion	https://www.sciencedirect.com/science/chapter/edited-volume/abs/pii/B9780124095175000838
dc.relation.ispartof	Coffee in Health and Disease Prevention
dc.rights.uri	N/A
dc.subject	Insulin Resistance
dc.subject	Hypertension
dc.subject	Caffeine
dc.subject	Obesity
dc.subject	Glucose intolerance
dc.title	Caffeine, Insulin Resistance, and Hypertension	eng
dc.title.alternative	Coffee in Health and Disease Prevention	eng
dc.type	book part
dspace.entity.type	Publication
oaire.citation.endPage	755
oaire.citation.startPage	747
oaire.citation.title	Coffee in Health and Disease Prevention
oaire.version	http://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyName	Guarino
person.givenName	Maria Pedro
person.identifier.ciencia-id	F21A-BD01-2D52
person.identifier.orcid	0000-0001-6079-1105
person.identifier.rid	B-5594-2015
person.identifier.scopus-author-id	56348477000
relation.isAuthorOfPublication	f163d4df-1e45-4278-affa-5994f206becf
relation.isAuthorOfPublication.latestForDiscovery	f163d4df-1e45-4278-affa-5994f206becf

Caffeine, Insulin Resistance, and Hypertension

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