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Molecular mechanisms linking environmental toxicants to cancer development: Significance for protective interventions with polyphenols

2022-11Journal article Open access
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dc.contributor.authorLagoa, Ricardo
dc.contributor.authorMarques-da-Silva, Dorinda
dc.contributor.authorDiniz, Mário
dc.contributor.authorDaglia, Maria
dc.contributor.authorBishayee, Anupam
dc.date.accessioned2022-09-29T13:17:52Z
dc.date.available2022-09-29T13:17:52Z
dc.date.issued2022-11
dc.description.abstractHuman exposure to environmental toxicants with diverse mechanisms of action is a growing concern. In addition to well-recognized carcinogens, various chemicals in environmental and occupational settings have been sug-gested to impact health, increasing susceptibility to cancer by inducing genetic and epigenetic changes. Accordingly, in this review, we have discussed recent insights into the pathological mechanisms of these chemicals, namely their effects on cell redox and calcium homeostasis, mitochondria and inflammatory signaling, with a focus on the possible implications for multi-stage carcinogenesis and its reversal by poly- phenols. Plant-derived polyphenols, such as epigallocatechin-gallate, resveratrol, curcumin and anthocyanins reduce the incidence of cancer and can be useful nutraceuticals for alleviating the detrimental outcomes of harmful pollutants. However, development of therapies based on polyphenol administration requires further studies to validate the biological efficacy, identifying effective doses, mode of action and new delivery forms. Innovative microphysiological testing models are presented and specific proposals for future trials are given. Merging the current knowledge of multifactorial actions of specific polyphenols and chief environmental toxi- cants, this work aims to potentiate the delivery of phytochemical-based protective treatments to individuals at high-risk due to environmental exposure.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLagoa, Ricardo, Marques-da-Silva, Dorinda, Diniz, Mário, Daglia, Maria, & Bishayee, Anupam (2022). Molecular mechanisms linking environmental toxicants to cancer development: Significance for protective interventions with polyphenols, Cancer Biology, 80, pp. 118-144. https://doi.org/10.1016/j.semcancer.2020.02.002.pt_PT
dc.identifier.doihttps://doi.org/10.1016/j.semcancer.2020.02.002pt_PT
dc.identifier.issn1044-579X
dc.identifier.urihttp://hdl.handle.net/10400.8/7744
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationUID/Multi/ 04378/2019pt_PT
dc.relationMultifunctional biomolecular systems for new methods of decontamination, protection and toxicological assessment
dc.subjectChemopreventionpt_PT
dc.subjectBenzo(a)pyrenept_PT
dc.subjectFlavonoidspt_PT
dc.subjectNatural compoundspt_PT
dc.subjectBioengineered modelspt_PT
dc.titleMolecular mechanisms linking environmental toxicants to cancer development: Significance for protective interventions with polyphenolspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMultifunctional biomolecular systems for new methods of decontamination, protection and toxicological assessment
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIA-MIB%2F31864%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FMAR-BIO%2F6044%2F2014/PT
oaire.citation.endPage144pt_PT
oaire.citation.startPage118pt_PT
oaire.citation.titleSeminars in Cancer Biologypt_PT
oaire.citation.volume80pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
person.familyNameLagoa
person.givenNameRicardo
person.identifier124357
person.identifier.ciencia-id5C18-A29A-44AB
person.identifier.ciencia-id521A-35C1-078D
person.identifier.orcid0000-0003-2375-6612
person.identifier.scopus-author-id23051352300
person.identifier.scopus-author-id35751117400
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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relation.isAuthorOfPublication20daf20e-f1d3-455c-a6fd-e10754cca411
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