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3D Photo-Fabrication for Tissue Engineering and Drug Delivery

2015-03Journal article Open access
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datacite.subject.fosEngenharia e Tecnologia
datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
dc.contributor.authorBrás Pereira, Rúben Filipe
dc.contributor.authorBartolo, Paulo
dc.date.accessioned2025-07-07T11:34:37Z
dc.date.available2025-07-07T11:34:37Z
dc.date.issued2015-03
dc.descriptionDocument type - Review
dc.description.abstractThe most promising strategies in tissue engineering involve the integration of a triad of biomaterials, living cells, and biologically active molecules to engineer synthetic environments that closely mimic the healing milieu present in human tissues, and that stimulate tissue repair and regeneration. To be clinically effective, these environments must replicate, as closely as possible, the main characteristics of the native extracellular matrix (ECM) on a cellular and subcellular scale. Photo-fabrication techniques have already been used to generate 3D environments with precise architectures and heterogeneous composition, through a multi-layer procedure involving the selective photocrosslinking reaction of a light-sensitive prepolymer. Cells and therapeutic molecules can be included in the initial hydrogel precursor solution, and processed into 3D constructs. Recently, photo-fabrication has also been explored to dynamically modulate hydrogel features in real time, providing enhanced control of cell fate and delivery of bioactive compounds. This paper focuses on the use of 3D photo-fabrication techniques to produce advanced constructs for tissue regeneration and drug delivery applications. State-of-the-art photo-fabrication techniques are described, with emphasis on the operating principles and biofabrication strategies to create spatially controlled patterns of cells and bioactive factors. Considering its fast processing, spatiotemporal control, high resolution, and accuracy, photo-fabrication is assuming a critical role in the design of sophisticated 3D constructs. This technology is capable of providing appropriate environments for tissue regeneration, and regulating the spatiotemporal delivery of therapeutics.eng
dc.description.sponsorshipAcknowledgements The authors thank the support of the Portuguese Foundation for Science and Technology (FCT) through the strategic project UID/Multi/04044/2013. Ruben F. Pereira is grateful to the FCT for the doctoral grant SFRH/BD/91151/2012.
dc.identifier.citationPereira, Rúben & Bártolo, Paulo (2015). 3D Photo-Fabrication for Tissue Engineering and Drug Delivery. Engineering. 1(1), 90-112. https://doi.org/10.15302/J-ENG-2015015.
dc.identifier.doi10.15302/j-eng-2015015
dc.identifier.issn2095-8099
dc.identifier.urihttp://hdl.handle.net/10400.8/13553
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationCentre for Rapid and Sustainable Product Development
dc.relationDISPOSITIVO DE BIOFABRICAÇÃO IN SITU PARA ENGENHARIA DE TECIDOS DA PELE
dc.relation.hasversionhttps://www.sciencedirect.com/science/article/pii/S2095809916300509
dc.relation.ispartofEngineering
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subject3D photo-fabrication
dc.subjectbiomaterials
dc.subjectdrug delivery
dc.subjecttissue engineering
dc.title3D Photo-Fabrication for Tissue Engineering and Drug Deliveryeng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre for Rapid and Sustainable Product Development
oaire.awardTitleDISPOSITIVO DE BIOFABRICAÇÃO IN SITU PARA ENGENHARIA DE TECIDOS DA PELE
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F04044%2F2013/PT
oaire.awardURIhttp://hdl.handle.net/10400.8/12921
oaire.citation.endPage112
oaire.citation.issue1
oaire.citation.startPage90
oaire.citation.titleEngineering
oaire.citation.volume1
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamFARH
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameBrás Pereira
person.familyNameBartolo
person.givenNameRúben Filipe
person.givenNamePaulo
person.identifier1337969
person.identifier203086
person.identifier.ciencia-id9417-153E-4473
person.identifier.ciencia-id5810-9BF9-4522
person.identifier.orcid0000-0002-7255-3400
person.identifier.orcid0000-0003-3683-726X
person.identifier.ridP-8503-2018
person.identifier.ridF-2421-2013
person.identifier.scopus-author-id55421048100
person.identifier.scopus-author-id6603353041
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
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relation.isAuthorOfPublicationab44d1ae-46d0-45c2-b19f-200024b5a990
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