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Evaluation of in vitro degradation of PCL scaffolds fabricated via BioExtrusion – Part 2: Influence of pore size and geometry: The present study is to accurately investigate the influence of design parameters, such as filament distance (FD) and lay-down pattern, on the degradation behaviour and kinetics of PCL scaffolds, obtained via BioExtrusion

2011-09Journal article Open access
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dc.contributor.authorDomingos, Marco
dc.contributor.authorChiellini, F.
dc.contributor.authorCometa, S.
dc.contributor.authorGiglio, E. De
dc.contributor.authorGrillo-Fernandes, E.
dc.contributor.authorBartolo, Paulo
dc.contributor.authorChiellini, E.
dc.date.accessioned2025-11-21T18:57:03Z
dc.date.available2025-11-21T18:57:03Z
dc.date.issued2011-09
dc.description.abstractThe in vivo degradation processes by which scaffolds degrade and are replaced by neo-tissue are complex and may be influenced by many factors, including environmental conditions, material properties, porosity and 3D architecture. The present study is focused on the influence of design parameters, filament distance (FD) and lay-down pattern, on the degradation kinetics of Polycaprolactone (PCL) scaffolds obtained via BioExtrusion. Through the variation of design parameters it was possible to obtain two groups of scaffolds with distinct pore geometry and size. The in vitro degradation was performed in simulated body fluid (SBF) and in phosphate buffer solution (PBS) for six months. Our results highlight a more complex degradation pattern of the scaffolds in SBF than in PBS, probably related to a mineral deposition. Significant statistical differences in weight loss values at month 6, allowed us to conclude that degradation kinetics of PCL scaffolds is strongly influenced by the pore size.eng
dc.description.sponsorshipThis work was performed within the framework of the European Network of Excellence ‘‘EXPERTISSUES’’ (Project NMP3-CT-2004-500283), with the partial financial support by Project PRIN 2006 prot. 2006038548. The authors wish to thank Mr. Piero Narducci in recording SEM images of scaffolds.
dc.identifier.citationDomingos, M., Chiellini, F., Cometa, S., Giglio, E. D., Grillo-Fernandes, E., Bartolo, P., & Chiellini, E. (2011). Evaluation of in vitro degradation of PCL scaffolds fabricated via BioExtrusion – Part 2: Influence of pore size and geometry: The present study is to accurately investigate the influence of design parameters, such as filament distance (FD) and lay-down pattern, on the degradation behaviour and kinetics of PCL scaffolds, obtained via BioExtrusion. Virtual and Physical Prototyping, 6(3), 157–165. https://doi.org/10.1080/17452759.2011.605839
dc.identifier.doi10.1080/17452759.2011.605839
dc.identifier.issn1745-2759
dc.identifier.issn1745-2767
dc.identifier.urihttp://hdl.handle.net/10400.8/14705
dc.language.isoeng
dc.peerreviewedyes
dc.publisherInforma UK Limited
dc.relation.hasversionhttps://www.tandfonline.com/doi/full/10.1080/17452759.2011.605839
dc.relation.ispartofVirtual and Physical Prototyping
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectbiomanufacturing
dc.subjectbiomaterials
dc.subjectscaffolds
dc.subjecttissue engineering
dc.subjectextrusion
dc.titleEvaluation of in vitro degradation of PCL scaffolds fabricated via BioExtrusion – Part 2: Influence of pore size and geometry: The present study is to accurately investigate the influence of design parameters, such as filament distance (FD) and lay-down pattern, on the degradation behaviour and kinetics of PCL scaffolds, obtained via BioExtrusioneng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage165
oaire.citation.issue3
oaire.citation.startPage157
oaire.citation.titleVirtual and Physical Prototyping
oaire.citation.volume6
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameDomingos
person.familyNameBartolo
person.givenNameMarco
person.givenNamePaulo
person.identifier203086
person.identifier.ciencia-idB512-2D06-5897
person.identifier.ciencia-id5810-9BF9-4522
person.identifier.orcid0000-0002-6693-790X
person.identifier.orcid0000-0003-3683-726X
person.identifier.ridF-2421-2013
person.identifier.scopus-author-id6603353041
relation.isAuthorOfPublication1fb3bd4b-f499-4db6-93c1-3a671f116d07
relation.isAuthorOfPublicationab44d1ae-46d0-45c2-b19f-200024b5a990
relation.isAuthorOfPublication.latestForDiscovery1fb3bd4b-f499-4db6-93c1-3a671f116d07

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