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Levodopa Incorporation in Alginate Membranes for Drug Delivery Studies

2013-08Comunicação em conferência Acesso restrito
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datacite.subject.fosCiências Médicas::Biotecnologia Médica
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
datacite.subject.sdg12:Produção e Consumo Sustentáveis
dc.contributor.authorFranco, Margarida Rosa
dc.contributor.authorViana, Tânia Filipa
dc.contributor.authorBiscaia, Sara
dc.contributor.authorBártolo, Paulo
dc.date.accessioned2026-04-09T09:49:04Z
dc.date.available2026-04-09T09:49:04Z
dc.date.issued2013-08
dc.description.abstractParkinsons Disease (PD) is the second most common progressive neurodegenerative disorder and is referred as a leading cause of neurologic disability. The symptoms and signs of PD result from a decrease of dopamines level in the basal ganglia. Accordingly to this, exogenous substitution with dopamine agonists like levodopa, is used to correct the mechanical disorders at the early stages of the disease. Levodopa is referred as a standard in the treatment of PD. The modern studies of PD drug development and experimental therapeutics focuses on the concept of slowing and targeting the release of levodopa to prolong the therapeutic effect and reduce the number of administrations. The transdermal route was thought to be the best route for providing a progressive supply of levodopa to the systemic circulation. Alginate was chosen as a drug carrier because of its biocompatible and biodegradable properties and also because it has been widely used in drug delivery systems (DDS). The aim of this research work was to produce alginate membranes with and without levodopa. A solvent casting based methodology was used. Calcium chloride was assayed as crosslinking agent. Membranes were characterized using Differential Scanning Calorimetry (DSC) techniques. Drug release was evaluated using UV Spectrophotometry.eng
dc.description.sponsorshipThe strategic project (PEST-OE/EME/UI 4044/2011) funded by the Portuguese Foundation for Science and Technology supported this work.
dc.identifier.citationFranco, M. C., Viana, T., Biscaia, S., & Bártolo, P. (2013). Levodopa incorporation in alginate membranes for drug delivery studies. Advanced Materials Research, 749, 423-428.
dc.identifier.doi10.4028/www.scientific.net/amr.749.423
dc.identifier.issn1662-8985
dc.identifier.urihttp://hdl.handle.net/10400.8/16078
dc.language.isoeng
dc.peerreviewedyes
dc.publisherTrans Tech Publications
dc.relationStrategic Project - UI 4044 - 2011-2012
dc.relation.hasversionhttps://www.scientific.net/AMR.749.423
dc.relation.ispartofAdvanced Materials Research
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectDrug delivery
dc.subjectLevodopa
dc.subjectParkinson
dc.subjectSodium alginate
dc.titleLevodopa Incorporation in Alginate Membranes for Drug Delivery Studieseng
dc.typeconference paper
dspace.entity.typePublication
oaire.awardNumberPEst-OE/EME/UI4044/2011
oaire.awardTitleStrategic Project - UI 4044 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FEME%2FUI4044%2F2011/PT
oaire.citation.conferenceDate2013
oaire.citation.endPage428
oaire.citation.startPage423
oaire.citation.titleAdvanced Materials Research
oaire.citation.volume749
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameFranco
person.familyNameViana
person.familyNameBiscaia
person.familyNameBartolo
person.givenNameMargarida
person.givenNameTânia
person.givenNameSara
person.givenNamePaulo
person.identifier2300879
person.identifier203086
person.identifier.ciencia-id3818-262C-0441
person.identifier.ciencia-idB41D-8BE0-7C9D
person.identifier.ciencia-id0516-3C03-93F3
person.identifier.ciencia-id5810-9BF9-4522
person.identifier.orcid0000-0001-9659-7646
person.identifier.orcid0000-0002-9688-647X
person.identifier.orcid0000-0002-2609-6878
person.identifier.orcid0000-0003-3683-726X
person.identifier.ridO-1147-2013
person.identifier.ridO-1146-2013
person.identifier.ridF-2421-2013
person.identifier.scopus-author-id55885992900
person.identifier.scopus-author-id55885892100
person.identifier.scopus-author-id55867382400
person.identifier.scopus-author-id6603353041
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
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