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Biomechanical performance of hybrid electrospun structures for skin regeneration

2018-08Journal article Restricted access
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dc.contributor.authorDias, J.R.
dc.contributor.authorBaptista-Silva, S.
dc.contributor.authorSousa, A.
dc.contributor.authorOliveira, A. L.
dc.contributor.authorBártolo, P. J.
dc.contributor.authorGranja, P. L.
dc.date.accessioned2023-05-31T10:11:39Z
dc.date.available2023-05-31T10:11:39Z
dc.date.issued2018-08
dc.descriptionThis study was supported by the Projects PTDC/BBB-ECT/2145/ 2014 and UID/Multi/04044/2013, financed by European Regional Development Fund (ERDF) through the Portuguese national programs Programa Operacional Factores de Competitividade (COMPETE), Portugal2020 and Norte2020, and by Portuguese funds through Fundação para a Ciência e a Tecnologia (FCT). This work is also supported by the research grants SFRH/BD/91104/2012 awarded to Juliana Dias and SFRH/BPD/90047/2012 awarded to Aureliana Sousa by FCT, and by the Investigator FCT program IF/00411/2013, awarded to Ana L. Oliveira. The authors thanks to CEMUP, University of Porto for the SEM images.pt_PT
dc.description.abstractWound dressings made by electrospun nanofibers have been demonstrating great potential to regenerate skin tissue as compared to the conventional membrane products available in the market. Until today most of the developed dressings have only demonstrated the capability to regenerate the dermis or epidermis. In this study we propose new hybrid electrospun meshes combining polycaprolactone and gelatin. Several approaches, multilayer, coating and blend were stablished to investigate the most appropriate hybrid structure with potential to promote skin regeneration in its full thickness. The structures were evaluated in terms of physico-chemical properties (porosity, water vapor permeability, contact angle and swelling degree) and according to its mechanical and biological performance. Multilayer and blend structures demonstrated to fit most of native skin requirements. However, looking to all the performed characterization we considered multilayer as the most promising hybrid structures, due its high porosity which contributed to an ideal water vapor permeability rate and good mechanical and biological properties. Based on this multilayer structure is a promisor wound dressing.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationDias, J. R., Baptista-Silva, S., Sousa, A., Oliveira, A. L., Bártolo, P. J., & Granja, P. L. (2018). Biomechanical performance of hybrid electrospun structures for skin regeneration. Materials Science and Engineering C, 93, 816–827. https://doi.org/10.1016/j.msec.2018.08.050pt_PT
dc.identifier.doi10.1016/j.msec.2018.08.050pt_PT
dc.identifier.issn0928-4931
dc.identifier.issn1873-0191
dc.identifier.urihttp://hdl.handle.net/10400.8/8541
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationCentre for Rapid and Sustainable Product Development
dc.relationCO-ELECTROSPINNING DE NANOFIBRAS DE PCL MODIFICADO E HIDROGEL CONTENDO CÉLULAS ENCAPSULADAS PARA REGENERAÇÃO DA PELE
dc.relationBIOPRINTED CELULLARIZED HYDROGELS FOR IN SITU SKIN REGENERATION
dc.relationSERICAMED - Designing Functional Silk-Based Biomaterials for In Situ Periodontal Regeneration.
dc.subjectHybrid structurespt_PT
dc.subjectElectrospun meshespt_PT
dc.subjectWound dressingspt_PT
dc.subjectECMpt_PT
dc.subjectSkin regenerationpt_PT
dc.titleBiomechanical performance of hybrid electrospun structures for skin regenerationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleCentre for Rapid and Sustainable Product Development
oaire.awardTitleCO-ELECTROSPINNING DE NANOFIBRAS DE PCL MODIFICADO E HIDROGEL CONTENDO CÉLULAS ENCAPSULADAS PARA REGENERAÇÃO DA PELE
oaire.awardTitleBIOPRINTED CELULLARIZED HYDROGELS FOR IN SITU SKIN REGENERATION
oaire.awardTitleSERICAMED - Designing Functional Silk-Based Biomaterials for In Situ Periodontal Regeneration.
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F04044%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/FARH/SFRH%2FBD%2F91104%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F90047%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Investigador FCT/IF%2F00411%2F2013%2FCP1167%2FCT0001/PT
oaire.citation.endPage827pt_PT
oaire.citation.startPage816pt_PT
oaire.citation.titleMaterials Science and Engineering: Cpt_PT
oaire.citation.volume93pt_PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamFARH
oaire.fundingStreamInvestigador FCT
person.familyNameDias
person.givenNameJuliana
person.identifier633669
person.identifier.ciencia-id0612-D971-F00D
person.identifier.orcid0000-0002-7079-1069
person.identifier.ridA-6086-2014
person.identifier.scopus-author-id55749822200
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsclosedAccesspt_PT
rcaap.typearticlept_PT
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