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Computer modelling and simulation of a bioreactor for tissue engineering

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datacite.subject.fosEngenharia e Tecnologia::Engenharia Médica
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
datacite.subject.sdg12:Produção e Consumo Sustentáveis
dc.contributor.authorPereira, Rúben F.
dc.contributor.authorFreitas, Dino
dc.contributor.authorTojeira, Ana
dc.contributor.authorAlmeida, Henrique A.
dc.contributor.authorAlves, Nuno
dc.contributor.authorBartolo, Paulo J.
dc.date.accessioned2026-07-07T09:22:34Z
dc.date.available2026-07-07T09:22:34Z
dc.date.issued2014
dc.description.abstractA conventional approach to tissue engineering involves the implantation of porous, biodegradable and biocompatible scaffolds seeded with cells into the defect site. In some strategies, tissue engineering requires the in vitro culture of tissueengineering constructs for implantation later. In this case, bioreactors are used to grow 3D tissues under controlled and monitored conditions. However, the quality of the resulting 3D tissue is highly dependent on the design and dimensions of the bioreactor, as well on the operating conditions. In this work, a computational fluid dynamic software package was used to investigate the influence of cylindrical bioreactor dimensions (length and diameter) on the fluid flow and scaffold shear stress. Computer simulations were performed using three different rotational movements (horizontal, vertical and biaxial rotation) and appropriate boundary conditions. Results show that the effect of the bioreactor length on the scaffold shear stress is more important than the diameter, while high length is associated to low scaffold shear stress. On the other hand, the fluid flows within the bioreactor and scaffold shear stresses are dependent on the rotational movement, being more uniform in the biaxial rotation due to the combination of rotational movements.eng
dc.description.sponsorshipThis research work was supported by the Portuguese Foundation for Science and Technology through the strategic project Pest-OE/EME/UI4044/2011 and by the European Union Seventh Framework Programme (FP7-PEOPLE-2009) under the grant agreement IRSES no. 247476.
dc.identifier.citationPereira, Rúben & Freitas, Dino & Tojeira, Ana & Almeida, Henrique & Alves, Nuno & Bártolo, Paulo. (2013). Computer modelling and simulation of a bioreactor for tissue engineering. International Journal of Computer Integrated Manufacturing. 27. 1-14. 10.1080/0951192X.2013.812244
dc.identifier.doi10.1080/0951192x.2013.812244
dc.identifier.issn0951-192X
dc.identifier.issn1362-3052
dc.identifier.urihttp://hdl.handle.net/10400.8/16549
dc.language.isoeng
dc.peerreviewedyes
dc.publisherInforma UK Limited
dc.relationStrategic Project - UI 4044 - 2011-2012
dc.relation.ispartofInternational Journal of Computer Integrated Manufacturing
dc.rights.uriN/A
dc.subjectTissue engineering
dc.subjectBioreactor
dc.subjectScaffold
dc.subjectComputational fluid dynamic
dc.titleComputer modelling and simulation of a bioreactor for tissue engineeringeng
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumberPEst-OE/EME/UI4044/2011
oaire.awardTitleStrategic Project - UI 4044 - 2011-2012
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/PEst-OE%2FEME%2FUI4044%2F2011/PT
oaire.citation.endPage959
oaire.citation.issue10
oaire.citation.startPage946
oaire.citation.titleInternational Journal of Computer Integrated Manufacturing
oaire.citation.volume27
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameAlves
person.familyNameBartolo
person.givenNameNuno
person.givenNamePaulo
person.identifier452149
person.identifier203086
person.identifier.ciencia-id311E-1559-8F6C
person.identifier.ciencia-id5810-9BF9-4522
person.identifier.orcid0000-0002-5016-0868
person.identifier.orcid0000-0003-3683-726X
person.identifier.ridN-4073-2013
person.identifier.ridF-2421-2013
person.identifier.scopus-author-id7006403383
person.identifier.scopus-author-id6603353041
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
relation.isAuthorOfPublicationbbd46a74-b77e-4539-a5fe-62ee95cdc4fa
relation.isAuthorOfPublicationab44d1ae-46d0-45c2-b19f-200024b5a990
relation.isAuthorOfPublication.latestForDiscoverybbd46a74-b77e-4539-a5fe-62ee95cdc4fa
relation.isProjectOfPublication44bd1c93-9ee1-4685-a408-c2baa61ffbcd
relation.isProjectOfPublication.latestForDiscovery44bd1c93-9ee1-4685-a408-c2baa61ffbcd

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