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Biomanufacturing for tissue engineering: Present and future trends

2009-12Journal article Open access
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datacite.subject.fosCiências Naturais::Matemáticas
datacite.subject.fosCiências Naturais::Ciências da Computação e da Informação
datacite.subject.fosEngenharia e Tecnologia::Outras Engenharias e Tecnologias
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
datacite.subject.sdg12:Produção e Consumo Sustentáveis
dc.contributor.authorBartolo, Paulo
dc.contributor.authorChua, C. K.
dc.contributor.authorAlmeida, Henrique de Amorim
dc.contributor.authorChou, S. M.
dc.contributor.authorLim, A. S. C.
dc.date.accessioned2025-06-13T12:09:48Z
dc.date.available2025-06-13T12:09:48Z
dc.date.issued2009-12
dc.description.abstractTissue engineering, often referred to as regenerative medicine and reparative medicine, is an interdisciplinary field that necessitates the combined effort of cell biologists, engineers, material scientists, mathematicians, geneticists, and clinicians toward the development of biological substitutes that restore, maintain, or improve tissue function. It has emerged as a rapidly expanding approach to address the organ shortage problem and comprises tissue regeneration and organ substitution. Cells placed on/or within constructs is the most common strategy in tissue engineering. Successful cell seeding depends on fast attachment of cell to scaffolds, high cell survival and uniform cell distribution. The seeding time is strongly dependent on the scaffold material and architecture. Scaffolds provide an initial biochemical substrate for the novel tissue until cells can produce their own extra-cellular matrix (ECM). Thus scaffolds not only define the 3D space for the formation of new tissues, but also serve to provide tissues with appropriate functions. These scaffolds are often critical, both in vivo (within the body) or in vitro (outside the body) mimicking in vivo conditions. Additive fabrication processes represent a new group of non-conventional fabrication techniques recently introduced in the biomedical engineering field. In tissue engineering, additive fabrication processes have been used to produce scaffolds with customised external shape and predefined internal morphology, allowing good control of pore size and pore distribution. This article provides a comprehensive state-of-the-art review of the application of biomanufacturing additive processes in the field of tissue engineering. New and moving trends in biomanufacturing technologies and the concept of direct cell-printing technologies are also discussed.eng
dc.description.sponsorshipThis research has been supported by the Portuguese Foundation for Science and Technology through the grant SFRH/BD/37604/2007 and the projects PTDC/EME-PME/71436/2006 and POCTI/SAU-BMA/60287/2004. It has been also supported by the Thematic Network on Biomanufacturing: Materials, Processes and Simulation funded by CYTED ‘Ciencia Y Tecnologia Para El Desarrollo’. In addition, contributions have been made with support from the Singapore Ministry of Education Academic Research Funds.
dc.identifier.citationBártolo, P. J., Chua, C. K., Almeida, H. A., Chou, S. M., & Lim, A. S. C. (2009). Biomanufacturing for tissue engineering: Present and future trends. Virtual and Physical Prototyping, 4(4), 203–216. https://doi.org/10.1080/17452750903476288.
dc.identifier.doi10.1080/17452750903476288
dc.identifier.eissn1745-2767
dc.identifier.issn1745-2759
dc.identifier.urihttp://hdl.handle.net/10400.8/13228
dc.language.isoeng
dc.peerreviewedyes
dc.publisherTaylor and Francis
dc.relationPROJECTO INTELIGENTE DE SCAFFOLDS OBTIDOS POR PROTOTIPAGEM RÁPIDA
dc.relationComputational Modelling of Bone Structure - Application to Bone Tissue Engineering
dc.relationPTDC/EME-PME/71436/2006
dc.relation.hasversionhttps://www.tandfonline.com/doi/full/10.1080/17452750903476288
dc.relation.ispartofVirtual and Physical Prototyping
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectBiomanufacturing
dc.subjectbiomaterials
dc.subjectscaffolds
dc.subjecttissue engineering
dc.titleBiomanufacturing for tissue engineering: Present and future trendseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitlePROJECTO INTELIGENTE DE SCAFFOLDS OBTIDOS POR PROTOTIPAGEM RÁPIDA
oaire.awardTitleComputational Modelling of Bone Structure - Application to Bone Tissue Engineering
oaire.awardURIhttp://hdl.handle.net/10400.8/13226
oaire.awardURIhttp://hdl.handle.net/10400.8/13227
oaire.citation.endPage216
oaire.citation.issue4
oaire.citation.startPage203
oaire.citation.titleVirtual and Physical Prototyping
oaire.citation.volume4
oaire.fundingStreamPIDDAC
oaire.fundingStream3599-PPCDT
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameBartolo
person.familyNameAlmeida
person.givenNamePaulo
person.givenNameHenrique de Amorim
person.identifier203086
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person.identifier.ciencia-id8F1D-4370-84BE
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person.identifier.orcid0000-0002-1367-2290
person.identifier.ridF-2421-2013
person.identifier.ridD-6275-2012
person.identifier.scopus-author-id6603353041
person.identifier.scopus-author-id55938867800
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Tissue engineering, often referred to as regenerative medicine and reparative medicine, is an interdisciplinary field that necessitates the combined effort of cell biologists, engineers, material scientists, mathematicians, geneticists, and clinicians toward the development of biological substitutes that restore, maintain, or improve tissue function. It has emerged as a rapidly expanding approach to address the organ shortage problem and comprises tissue regeneration and organ substitution. Cells placed on/or within constructs is the most common strategy in tissue engineering. Successful cell seeding depends on fast attachment of cell to scaffolds, high cell survival and uniform cell distribution. The seeding time is strongly dependent on the scaffold material and architecture. Scaffolds provide an initial biochemical substrate for the novel tissue until cells can produce their own extra-cellular matrix (ECM). Thus scaffolds not only define the 3D space for the formation of new tissues, but also serve to provide tissues with appropriate functions. These scaffolds are often critical, both in vivo (within the body) or in vitro (outside the body) mimicking in vivo conditions. Additive fabrication processes represent a new group of non-conventional fabrication techniques recently introduced in the biomedical engineering field. In tissue engineering, additive fabrication processes have been used to produce scaffolds with customised external shape and predefined internal morphology, allowing good control of pore size and pore distribution. This article provides a comprehensive state-of-the-art review of the application of biomanufacturing additive processes in the field of tissue engineering. New and moving trends in biomanufacturing technologies and the concept of direct cell-printing technologies are also discussed.Tissue engineering, often referred to as regenerative medicine and reparative medicine, is an interdisciplinary field that necessitates the combined effort of cell biologists, engineers, material scientists, mathematicians, geneticists, and clinicians toward the development of biological substitutes that restore, maintain, or improve tissue function. It has emerged as a rapidly expanding approach to address the organ shortage problem and comprises tissue regeneration and organ substitution. Cells placed on/or within constructs is the most common strategy in tissue engineering. Successful cell seeding depends on fast attachment of cell to scaffolds, high cell survival and uniform cell distribution. The seeding time is strongly dependent on the scaffold material and architecture. Scaffolds provide an initial biochemical substrate for the novel tissue until cells can produce their own extra-cellular matrix (ECM). Thus scaffolds not only define the 3D space for the formation of new tissues, but also serve to provide tissues with appropriate functions. These scaffolds are often critical, both in vivo (within the body) or in vitro (outside the body) mimicking in vivo conditions. Additive fabrication processes represent a new group of non-conventional fabrication techniques recently introduced in the biomedical engineering field. In tissue engineering, additive fabrication processes have been used to produce scaffolds with customised external shape and predefined internal morphology, allowing good control of pore size and pore distribution. This article provides a comprehensive state-of-the-art review of the application of biomanufacturing additive processes in the field of tissue engineering. New and moving trends in biomanufacturing technologies and the concept of direct cell-printing technologies are also discussed.
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