Additive manufacturing of tissues and organs

Melchels, Ferry P.W.; Domingos, Marco; Klein, Travis J.; Malda, Jos; Bártolo, Paulo J.; Hutmacher, Dietmar W.

Publication

Additive manufacturing of tissues and organs

2012-08Journal article

datacite.subject.fos	Ciências Médicas::Biotecnologia Médica
datacite.subject.fos	Engenharia e Tecnologia::Engenharia dos Materiais
datacite.subject.fos	Engenharia e Tecnologia::Engenharia Mecânica
datacite.subject.sdg	03:Saúde de Qualidade
datacite.subject.sdg	09:Indústria, Inovação e Infraestruturas
datacite.subject.sdg	12:Produção e Consumo Sustentáveis
dc.contributor.author	Melchels, Ferry P.W.
dc.contributor.author	Domingos, Marco
dc.contributor.author	Klein, Travis J.
dc.contributor.author	Malda, Jos
dc.contributor.author	Bártolo, Paulo J.
dc.contributor.author	Hutmacher, Dietmar W.
dc.date.accessioned	2026-01-15T15:48:32Z
dc.date.available	2026-01-15T15:48:32Z
dc.date.issued	2012-08
dc.description.abstract	Additive manufacturing techniques offer the potential to fabricate organized tissue constructs to repair or replace damaged or diseased human tissues and organs. Using these techniques, spatial variations of cells along multiple axes with high geometric complexity in combination with different biomaterials can be generated. The level of control offered by these computer-controlled technologies to design and fabricate tissues will accelerate our understanding of the governing factors of tissue formation and function. Moreover, it will provide a valuable tool to study the effect of anatomy on graft performance. In this review, we discuss the rationale for engineering tissues and organs by combining computer-aided design with additive manufacturing technologies that encompass the simultaneous deposition of cells and materials. Current strategies are presented, particularly with respect to limitations due to the lack of suitable polymers, and requirements to move the current concepts to practical application.	eng
dc.description.sponsorship	For funding we thank the European Union (Marie Curie International Outgoing Fellowship to F.P.W. Melchels) and the Australian Research Council (ARC).
dc.identifier.citation	Ferry P.W. Melchels, Marco A.N. Domingos, Travis J. Klein, Jos Malda, Paulo J. Bartolo, Dietmar W. Hutmacher, Additive manufacturing of tissues and organs, Progress in Polymer Science, Volume 37, Issue 8, 2012, Pages 1079-1104, ISSN 0079-6700, https://doi.org/10.1016/j.progpolymsci.2011.11.007.
dc.identifier.doi	10.1016/j.progpolymsci.2011.11.007
dc.identifier.issn	0079-6700
dc.identifier.uri	http://hdl.handle.net/10400.8/15350
dc.language.iso	eng
dc.peerreviewed	yes
dc.publisher	Elsevier
dc.relation.hasversion	https://www.sciencedirect.com/science/article/pii/S0079670011001328
dc.relation.ispartof	Progress in Polymer Science
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subject	Additive manufacturing
dc.subject	Bioprinting
dc.subject	Biofabrication
dc.subject	Hydrogels
dc.subject	Tissue engineering
dc.title	Additive manufacturing of tissues and organs	eng
dc.type	journal article
dspace.entity.type	Publication
oaire.citation.endPage	1104
oaire.citation.issue	8
oaire.citation.startPage	1079
oaire.citation.title	Progress in Polymer Science
oaire.citation.volume	37
oaire.version	http://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyName	Domingos
person.familyName	Bartolo
person.givenName	Marco
person.givenName	Paulo
person.identifier	203086
person.identifier.ciencia-id	B512-2D06-5897
person.identifier.ciencia-id	5810-9BF9-4522
person.identifier.orcid	0000-0002-6693-790X
person.identifier.orcid	0000-0003-3683-726X
person.identifier.rid	F-2421-2013
person.identifier.scopus-author-id	6603353041
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