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Expanding the Potential of Self-Assembled Silk Fibroin as Aerogel Particles for Tissue Regeneration

2023-11-09Artigo científico Acesso aberto
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datacite.subject.fosCiências Médicas::Ciências da Saúde
datacite.subject.fosEngenharia e Tecnologia::Engenharia dos Materiais
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorBernardes, Beatriz G.
dc.contributor.authorBaptista-Silva, Sara
dc.contributor.authorIllanes-Bordomás, Carlos
dc.contributor.authorMagalhães, Rui
dc.contributor.authorDias, Juliana Rosa
dc.contributor.authorAlves, Nuno M. F.
dc.contributor.authorCosta, Raquel
dc.contributor.authorGarcía-González, Carlos A.
dc.contributor.authorOliveira, Ana Leite
dc.date.accessioned2026-09-07T15:22:28Z
dc.date.available2026-09-07T15:22:28Z
dc.date.issued2023-11-09en_US
dc.date.updated2026-09-02T15:51:45Z
dc.descriptionArticle number - 2605.
dc.descriptionThis article belongs to the Special Issue Novel Technologies for Buccal and Transdermal Drug Delivery.
dc.description.abstractA newly produced silk fibroin (SF) aerogel particulate system using a supercritical carbon dioxide (scCO2)-assisted drying technology is herein proposed for biomedical applications. Different concentrations of silk fibroin (3%, 5%, and 7% (w/v)) were explored to investigate the potential of this technology to produce size- and porosity-controlled particles. Laser diffraction, helium pycnometry, nitrogen adsorption–desorption analysis and Fourier Transform Infrared with Attenuated Total Reflectance (FTIR-ATR) spectroscopy were performed to characterize the physicochemical properties of the material. The enzymatic degradation profile of the SF aerogel particles was evaluated by immersion in protease XIV solution, and the biological properties by cell viability and cell proliferation assays. The obtained aerogel particles were mesoporous with high and concentration dependent specific surface area (203–326 m2/g). They displayed significant antioxidant activity and sustained degradation in the presence of protease XIV enzyme. The in vitro assessment using human dermal fibroblasts (HDF) confirm the particles’ biocompatibility, as well as the enhancement in cell viability and proliferation.eng
dc.description.sponsorshipThis research was supported by National Funds from Fundação para a Ciência e a Tecnologia (FCT), through project UID/Multi/50016/2020. B.G.B. acknowledges FCT for a Doctoral Research Grant 2021.05717.BD; and C. I.-B. acknowledges MCINN and FSE+ for a FPI fellowship (PRE2021-097177/AEI/10.13039/501100011033). This research was also funded by MICINN [PID2020-120010RB-I00/AEI/10.13039/501100011033], Xunta de Galicia [ED431C 2020/17], Agencia Estatal de Investigación [AEI] and FEDER funds. Work carried out in the framework of the COST Action CA18125 “Advanced Engineering and Research of aeroGels for Environment and Life Sciences” (AERoGELS); and project TEX4WOUNDS (POCI-01-0247-FEDER-047029), financed under the Incentive System for Research and Technological Development, R&DT Projects in co-promotion (Notice SI/17/2019). This work was financially supported by the Fundação para a Ciência e a Tecnologia FCT/MCTES (PIDDAC) through the following Projects: UIDB/04044/2020; UIDP/04044/2020; Associate Laboratory ARISE LA/P/0112/2020; PTCentroDiH (03/C16-i03/2022-768), “OP-SMARTherapy, 2022.04238.PTDC”, “InnovaBIOMAS, 2022.10564.PTDC, INOV.AM - Inovação em Fabricação Aditiva, 02-C05-i01.01-2022.PC644865234-00000004 (WP14). This study was also supported by European Union through PREDICTOS “PREDICTOS, 101079372”.
dc.description.versionN/A
dc.identifier.citationBernardes, B. G., Baptista-Silva, S., Illanes-Bordomás, C., Magalhães, R., Dias, J. R., Alves, N. M. F., Costa, R., García-González, C. A., & Oliveira, A. L. (2023). Expanding the potential of self-assembled silk fibroin as aerogel particles for tissue regeneration. Pharmaceutics, 15(11), Artigo 2605. https://doi.org/10.3390/pharmaceutics15112605
dc.identifier.doi10.3390/pharmaceutics15112605en_US
dc.identifier.eid2-s2.0-85178378225en_US
dc.identifier.eissn1999-4923
dc.identifier.slugcv-prod-3601461
dc.identifier.urihttp://hdl.handle.net/10400.8/16797
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationAEROREGEN: Natural-based AEROgel formulations towards healing and REGENeration of diabetic wounds
dc.relationCentre for Rapid and Sustainable Product Development
dc.relationCentre for Rapid and Sustainable Product Development
dc.relationAdvanced Production and Intelligent Systems
dc.relation.hasversionhttps://www.mdpi.com/1999-4923/15/11/2605
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectaerogel
dc.subjectparticles and silk fibroin
dc.subjecttissue engineering
dc.titleExpanding the Potential of Self-Assembled Silk Fibroin as Aerogel Particles for Tissue Regenerationeng
dc.typejournal article
dspace.entity.typePublication
oaire.awardNumber2021.05717.BD
oaire.awardNumberUIDB/04044/2020
oaire.awardNumberUIDP/04044/2020
oaire.awardNumberLA/P/0112/2020
oaire.awardTitleAEROREGEN: Natural-based AEROgel formulations towards healing and REGENeration of diabetic wounds
oaire.awardTitleCentre for Rapid and Sustainable Product Development
oaire.awardTitleCentre for Rapid and Sustainable Product Development
oaire.awardTitleAdvanced Production and Intelligent Systems
oaire.awardURIhttp://hdl.handle.net/10400.8/16796
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04044%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04044%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0112%2F2020/PT
oaire.citation.endPage19
oaire.citation.issue11en_US
oaire.citation.startPage1
oaire.citation.titlePharmaceuticsen_US
oaire.citation.volume15en_US
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameDias
person.familyNameAlves
person.givenNameJuliana
person.givenNameNuno
person.identifier633669
person.identifier452149
person.identifier.ciencia-id0612-D971-F00D
person.identifier.ciencia-id311E-1559-8F6C
person.identifier.orcid0000-0002-7079-1069
person.identifier.orcid0000-0002-5016-0868
person.identifier.ridA-6086-2014
person.identifier.ridN-4073-2013
person.identifier.scopus-author-id55749822200
person.identifier.scopus-author-id7006403383
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.cv.cienciaid0612-D971-F00D | Juliana Rosa Dias
rcaap.rightsopenAccessen_US
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