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Production and Characterisation of PCL/ES Scaffolds for Bone Tissue Engineering

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datacite.subject.fosEngenharia e Tecnologia
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorBiscaia, Sara I.
dc.contributor.authorViana, Tânia F.
dc.contributor.authorAlmeida, Henrique A.
dc.contributor.authorBártolo, Paulo J.
dc.date.accessioned2025-12-15T16:29:18Z
dc.date.available2025-12-15T16:29:18Z
dc.date.issued2015
dc.description
dc.description.abstractThe combination of bio-fillers with synthetic polymers has been an exciting route for developing tissue engineering scaffolds, in particular for bone tissue regeneration. In this study, poly(e{open}-caprolactone) (PCL) scaffolds were produced using an additive manufacturing technique and eggshell (ES) powder was used as a filler. The morphology of PCL and PCL/ES scaffolds were analysed and the effect of ES in the polymer matrix was characterized using techniques of Differential Scanning Calorimetry and Thermogravimetric Analysis, Fourier Transform Infrared Spectroscopy (FT-IR) and X-ray Diffraction (XRD). Morphological observation revealed that the incorporation of ES in the polymer matrix modifies the flow behaviour of the material in spite of the same processing parameters, resulting in a decrease of scaffold pore size. Thermal analysis showed that the addition of the bio-filler improves the crystallization properties and thermal stability of the PCL. FT-IR spectra of ES powder showed characteristic bands of calcium carbonate and processed materials spectra indicated no changes on the functional groups compared to non-processed materials. Crystalline nature of ES was demonstrated through a characteristic broad peak in XRD pattern around 30o, which was also observed in the composites XRD spectra. The results indicate the potential of ES powder to be used as a filler for bio-based polymer scaffold composites.eng
dc.description.sponsorshipThe authors are grateful to Professor Mara Braga (Chemical Engineering Department Faculty of Sciences and Technology, University of Coimbra) for her valuable help with XRD analysis. Research funded by the Strategic Project (PEST-OE/EME/UI 4044/2013) from the Portuguese Foundation for Science and Technology.
dc.identifier.citationBiscaia, Sara & Viana, Tânia & Almeida, Henrique & Bártolo, Paulo. (2015). Production and Characterisation of PCL/ES Scaffolds for Bone Tissue Engineering. Materials Today: Proceedings. 2. 10.1016/j.matpr.2015.04.024.
dc.identifier.doi10.1016/j.matpr.2015.04.024
dc.identifier.issn2214-7853
dc.identifier.urihttp://hdl.handle.net/10400.8/15066
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier
dc.relationStrategic Project - UI 4044 - 2013-2014
dc.relation.hasversionhttps://www.sciencedirect.com/science/article/pii/S2214785315000255
dc.relation.ispartofMaterials Today: Proceedings
dc.rights.uriN/A
dc.subjectBone regeneration
dc.subjectEggshell
dc.subjectPolycaprolactone
dc.subjectScaffold
dc.titleProduction and Characterisation of PCL/ES Scaffolds for Bone Tissue Engineeringeng
dc.title.alternative5th International conference on Advanced Nano Materialseng
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleStrategic Project - UI 4044 - 2013-2014
oaire.awardURIhttp://hdl.handle.net/10400.8/13452
oaire.citation.endPage216
oaire.citation.issue1
oaire.citation.startPage208
oaire.citation.titleMaterials Today: Proceedings
oaire.citation.volume2
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameBiscaia
person.familyNameViana
person.familyNameAlmeida
person.familyNameBartolo
person.givenNameSara
person.givenNameTânia
person.givenNameHenrique de Amorim
person.givenNamePaulo
person.identifier46395
person.identifier203086
person.identifier.ciencia-id0516-3C03-93F3
person.identifier.ciencia-idB41D-8BE0-7C9D
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person.identifier.ciencia-id5810-9BF9-4522
person.identifier.orcid0000-0002-2609-6878
person.identifier.orcid0000-0002-9688-647X
person.identifier.orcid0000-0002-1367-2290
person.identifier.orcid0000-0003-3683-726X
person.identifier.ridO-1146-2013
person.identifier.ridO-1147-2013
person.identifier.ridD-6275-2012
person.identifier.ridF-2421-2013
person.identifier.scopus-author-id55867382400
person.identifier.scopus-author-id55885892100
person.identifier.scopus-author-id55938867800
person.identifier.scopus-author-id6603353041
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