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45S5 BAG-Ti6Al4V structures: The influence of the design on some of the physical and chemical interactions that drive cellular response

2018Journal article Open access
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dc.contributor.authorMelo-Fonseca, F.
dc.contributor.authorLima, R.
dc.contributor.authorCosta, M.M.
dc.contributor.authorBartolomeu, F.
dc.contributor.authorAlves, Nuno
dc.contributor.authorMiranda, A.
dc.contributor.authorGasik, M.
dc.contributor.authorSilva, F.S.
dc.contributor.authorSilva, N.A.
dc.contributor.authorMiranda, G.
dc.date.accessioned2023-04-24T13:11:50Z
dc.date.available2023-04-24T13:11:50Z
dc.date.issued2018
dc.descriptionThis work was supported by FCT (Fundação para a Ciência e Tecnologia) through the grants SFRH/BPD/112111/2015, SFRH/BD/128657/2017, PD/BDE/127836/2016, SFRH/BPD/97701/2013, SFRH/ BD/141056/2018, SFRH/BD/140191/2018 and the projects PTDC/EMSTEC/5422/2014 and NORTE-01-0145-FEDER-000018-HAMaBICo. Additionally, this work was supported by FCT with the reference project UID/EEA/04436/2013, by FEDER funds through the COMPETE 2020 – Programa Operacional Competitividade e Internacionalização (POCI) with the reference project POCI-01-0145-FEDER-006941.pt_PT
dc.description.abstractMulti-material Ti6Al4V cellular structures impregnated with 45S5 bioactive glass were designed and produced using Selective LaserMelting (SLM), an additive manufacturing technique, combinedwith Press and Sintering focusing on load bearing components like hip implants. These structures were designed to combine Ti6Al4V mechanical properties and promote bone ingrowth into the structure as the bioactive material (45S5) is being absorbed and replaced by newly formed bone. The influence of these structures design on some of the physical and chemical aspects that drive cellular response was assessed. Roughness, wettability, bioactive glass quantity and quality on the structures after processing and the pH measured during cell culture (as a consequence of bioactive glass dissolution) were evaluated and correlated with cellular viability, cellular distribution, morphology and proliferation on the surface and inside the structures.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationF. Melo-Fonseca, R. Lima, M.M. Costa, F. Bartolomeu, N. Alves, A. Miranda, M. Gasik, F.S. Silva, N.A. Silva, G. Miranda, 45S5 BAG-Ti6Al4V structures: The influence of the design on some of the physical and chemical interactions that drive cellular response, Materials & Design, Volume 160, 2018, Pages 95-105, ISSN 0264-1275, https://doi.org/10.1016/j.matdes.2018.08.056.pt_PT
dc.identifier.doi10.1016/j.matdes.2018.08.056pt_PT
dc.identifier.issn0264-1275
dc.identifier.issn1873-4197
dc.identifier.urihttp://hdl.handle.net/10400.8/8444
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationDevelopment of Multi-Functional Structures by Multi-Material Selective Laser Melting/Sintering
dc.relationSmart design of Titanium/NiTi cellular structured implants by Multi-Material-Selective-Laser-Melting
dc.relationA Poly-Pahrmacological Therapy to Repair the Injured Spinal Cord
dc.relationA POLY-PHARMACOLOGICAL THERAPY TO REPAIR THE INJURED SPINAL CORD. IS IT THE WHOLE GREATER THAN THE SUM OF ITS PARTS
dc.relationDesign of bone-stimulating implants by mechanotransduction modulation
dc.relationalterado para: “Multi-Functional Multi-Material Structures for Orthopedic Implants using Laser-Assisted Strategies” Smart Bioactive Structures for Implants for Life
dc.relationMicroelectromechanical Systems Research Unit
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0264127518306786pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectMulti-material cellular structurespt_PT
dc.subjectSelective Laser Melting Press and Sintering Ti6Al4V Bioactive glass 45S5pt_PT
dc.subjectPress and Sintering Ti6Al4V Bioactive glass 45S5pt_PT
dc.subjectTi6Al4Vpt_PT
dc.subjectBioactive glass 45S5pt_PT
dc.title45S5 BAG-Ti6Al4V structures: The influence of the design on some of the physical and chemical interactions that drive cellular responsept_PT
dc.typejournal article
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oaire.awardTitleDevelopment of Multi-Functional Structures by Multi-Material Selective Laser Melting/Sintering
oaire.awardTitleSmart design of Titanium/NiTi cellular structured implants by Multi-Material-Selective-Laser-Melting
oaire.awardTitleA Poly-Pahrmacological Therapy to Repair the Injured Spinal Cord
oaire.awardTitleA POLY-PHARMACOLOGICAL THERAPY TO REPAIR THE INJURED SPINAL CORD. IS IT THE WHOLE GREATER THAN THE SUM OF ITS PARTS
oaire.awardTitleDesign of bone-stimulating implants by mechanotransduction modulation
oaire.awardTitlealterado para: “Multi-Functional Multi-Material Structures for Orthopedic Implants using Laser-Assisted Strategies” Smart Bioactive Structures for Implants for Life
oaire.awardTitleMicroelectromechanical Systems Research Unit
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F112111%2F2015/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F128657%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//PD%2FBDE%2F127836%2F2016/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F97701%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F141056%2F2018/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POR_NORTE/SFRH%2FBD%2F140191%2F2018/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FEEA%2F04436%2F2013/PT
oaire.citation.endPage105pt_PT
oaire.citation.startPage95pt_PT
oaire.citation.titleMaterials and Designpt_PT
oaire.citation.volume160pt_PT
oaire.fundingStreamPOR_NORTE
oaire.fundingStreamPOR_NORTE
oaire.fundingStream6817 - DCRRNI ID
person.familyNameAlves
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person.identifier452149
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rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
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