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Oxidative Stress and Inflammatory Response of Skin Fibroblasts Exposed to Chlorpyrifos

2022-07-13Comunicação em conferência Acesso aberto
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datacite.subject.fosEngenharia e Tecnologia::Engenharia Química
datacite.subject.sdg11:Cidades e Comunidades Sustentáveis
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorSilva, Zélia
dc.contributor.authorAlmeida, Danielle
dc.contributor.authorMarques-da-Silva, Dorinda
dc.contributor.authorLagoa, Ricardo
dc.contributor.authorVideira, Paula A.
dc.date.accessioned2026-03-23T10:53:49Z
dc.date.available2026-03-23T10:53:49Z
dc.date.issued2022-07-13
dc.descriptionArticle number - 7
dc.descriptionThis article belongs to the Proceedings Biosystems in Toxicology and Pharmacology—Current Challenges.
dc.descriptionAll authors have read and agreed to the published version of the manuscript.
dc.descriptionMedical Sciences Forum, Volume 11, Issue 1 BiTaP 2022 Biosystems in Toxicology and Pharmacology—Current Challenges Online | 8–9 September 2022
dc.description.abstractChlorpyrifos (CPF) is a widely used insecticide. The aim of this work was to study the effect of CPF in skin fibroblasts exposed to concentrations detected in human skin and unleash underlying cellular mechanisms. Fibroblasts were exposed to different concentrations (0.36–250 µM) of CPF pure alone or in a commercial CPF mixture (Lethal 20) for 6 days. In conclusion, prolonged exposure to 250 µM of CPF pure and 125 µM of Lethal 20 caused a significant loss of the fibroblast´s viability. Moreover, the toxicity of this pesticide in fibroblasts is evidenced by the induction of oxidative stress and stimulation of the production of interleukin (IL)-6.eng
dc.description.sponsorshipFunding: This research was funded by Fundação para a Ciência e Tecnologia (FCT – Portugal) through the research project PTDC/BIA-MIB/31864/2017. It was also funded by FCT- Portugal in the scope of the unit projects UIDP/04378/2020 and UIDB/04378/2020 (UCIBIO), LA/P/0140/2020 (i4HB), LA/P/0045/2020 (ALiCE), UIDB/50020/2020 and UIDP/50020/2020 (LSRE-LCM).
dc.identifier.citationSilva, Z., Almeida, D., Marques-da-Silva, D., Lagoa, R., & Videira, P. A. (2022). Oxidative Stress and Inflammatory Response of Skin Fibroblasts Exposed to Chlorpyrifos. Medical Sciences Forum, 11(1), 7. https://doi.org/10.3390/BiTaP-12791
dc.identifier.doi10.3390/bitap-12791
dc.identifier.eissn2673-9992
dc.identifier.urihttp://hdl.handle.net/10400.8/15943
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI
dc.relationMultifunctional biomolecular systems for new methods of decontamination, protection and toxicological assessment
dc.relationApplied Molecular Biosciences Unit
dc.relationApplied Molecular Biosciences Unit
dc.relationInstitute for Health and Bioeconomy
dc.relationLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
dc.relationLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
dc.relation.hasversionhttps://www.mdpi.com/2673-9992/11/1/7
dc.relation.ispartofBiosystems in Toxicology and Pharmacology—Current Challenges
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectchlorpyrifos
dc.subjectimmunotoxicology
dc.subjectinflammation
dc.subjectoxidative stress
dc.subjectskin fibroblasts
dc.subjectIL-6
dc.titleOxidative Stress and Inflammatory Response of Skin Fibroblasts Exposed to Chlorpyrifoseng
dc.typeconference paper
dspace.entity.typePublication
oaire.awardNumberPTDC/BIA-MIB/31864/2017
oaire.awardNumberUIDP/04378/2020
oaire.awardNumberUIDB/04378/2020
oaire.awardNumberLA/P/0140/2020
oaire.awardNumberUIDB/50020/2020
oaire.awardNumberUIDP/50020/2020
oaire.awardTitleMultifunctional biomolecular systems for new methods of decontamination, protection and toxicological assessment
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardTitleInstitute for Health and Bioeconomy
oaire.awardTitleLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
oaire.awardTitleLaboratory of Separation and Reaction Engineering - Laboratory of Catalysis and Materials
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIA-MIB%2F31864%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04378%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04378%2F2020/PT
oaire.awardURIhttp://hdl.handle.net/10400.8/13764
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50020%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50020%2F2020/PT
oaire.citation.conferenceDate2022-09
oaire.citation.conferencePlaceOnline
oaire.citation.endPage4
oaire.citation.issue1
oaire.citation.startPage1
oaire.citation.titleMedical Sciences Forum
oaire.citation.volume11
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameMarques da Silva
person.familyNameLagoa
person.givenNameDorinda
person.givenNameRicardo
person.identifier124357
person.identifier.ciencia-id5C18-A29A-44AB
person.identifier.orcid0000-0003-0460-5421
person.identifier.orcid0000-0003-2375-6612
person.identifier.scopus-author-id23051352300
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.nameFundação para a Ciência e a Tecnologia
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