Logo do repositório
 
Publicação

Fabrication of channeled scaffolds with ordered array of micro-pores through microsphere leaching and indirect Rapid Prototyping technique

2012-08-26Artigo científico Acesso restrito
Ver registo simples
datacite.subject.fosEngenharia e Tecnologia::Engenharia dos Materiais
datacite.subject.sdg03:Saúde de Qualidade
datacite.subject.sdg09:Indústria, Inovação e Infraestruturas
datacite.subject.sdg12:Produção e Consumo Sustentáveis
dc.contributor.authorTan, J. Y.
dc.contributor.authorChua, Chee Kai
dc.contributor.authorLeong, K. F.
dc.date.accessioned2026-03-17T11:30:30Z
dc.date.available2026-03-17T11:30:30Z
dc.date.issued2012-08-26
dc.description.abstractAdvanced scaffold fabrication techniques such as Rapid Prototyping (RP) are generally recognized to be advantageous over conventional fabrication methods in terms architectural control and reproducibility. Yet, most RP techniques tend to suffer from resolution limitations which result in scaffolds with uncontrollable, random-size pores and low porosity, albeit having interconnected channels which is characteristically present in most RP scaffolds. With the increasing number of studies demonstrating the profound influences of scaffold pore architecture on cell behavior and overall tissue growth, a scaffold fabrication method with sufficient architectural control becomes imperative. The present study demonstrates the use of RP fabrication techniques to create scaffolds having interconnected channels as well as controllable micro-size pores. Adopted from the concepts of porogen leaching and indirect RP techniques, the proposed fabrication method uses monodisperse microspheres to create an ordered, hexagonal closed packed (HCP) array of micro-pores that surrounds the existing channels of the RP scaffold. The pore structure of the scaffold is shaped using a single sacrificial construct which comprises the microspheres and a dissolvable RP mold that were sintered together. As such, the size of pores as well as the channel configuration of the scaffold can be tailored based on the design of the RP mold and the size of microspheres used. The fabrication method developed in this work can be a promising alternative way of preparing scaffolds with customized pore structures that may be required for specific studies concerning cell-scaffold interactions.eng
dc.description.sponsorshipThe authors gratefully acknowledge the financial support of both the Singapore Agency for Science, Technology and Research (ASTAR) through the Singapore-University of Washington Alliance (SUWA) programme and Nanyang Technological University (NTU).
dc.identifier.citationTan, J.Y., Chua, C.K. & Leong, K.F. Fabrication of channeled scaffolds with ordered array of micro-pores through microsphere leaching and indirect Rapid Prototyping technique. Biomed Microdevices 15, 83–96 (2013). https://doi.org/10.1007/s10544-012-9690-3
dc.identifier.doi10.1007/s10544-012-9690-3
dc.identifier.issn1387-2176
dc.identifier.issn1572-8781
dc.identifier.urihttp://hdl.handle.net/10400.8/15892
dc.language.isoeng
dc.peerreviewedyes
dc.publisherSpringer
dc.relation.hasversionhttps://link.springer.com/article/10.1007/s10544-012-9690-3
dc.relation.ispartofBiomedical Microdevices
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectMicrosphere leaching
dc.subjectRapid prototyping
dc.subjectScaffold fabrication
dc.subjectTissue Engineering
dc.titleFabrication of channeled scaffolds with ordered array of micro-pores through microsphere leaching and indirect Rapid Prototyping techniqueeng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage96
oaire.citation.issue1
oaire.citation.startPage83
oaire.citation.titleBiomed Microdevices
oaire.citation.volume15
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.affiliation.nameCDRSP
person.familyNameChua
person.givenNameChee Kai
person.identifier.orcid0000-0003-4536-6199
person.identifier.scopus-author-id57203930410
relation.isAuthorOfPublication972e5a1e-e720-4d37-9c77-a271229cc790
relation.isAuthorOfPublication.latestForDiscovery972e5a1e-e720-4d37-9c77-a271229cc790

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura indisponível
Nome:
Fabrication of channeled scaffolds with ordered array of micro-pores through microsphere leaching and indirect Rapid Prototyping technique.pdf
Tamanho:
1.15 MB
Formato:
Adobe Portable Document Format
Ver/Abrir
Licença
A mostrar 1 - 1 de 1
Miniatura indisponível
Nome:
license.txt
Tamanho:
1.32 KB
Formato:
Item-specific license agreed upon to submission
Descrição:
Ver/Abrir

Coleções

CDRsp - Artigos em revistas internacionais